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Conserved domains on  [gi|85544141|pdb|2AXL|A]
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Chain A, Werner syndrome

Protein Classification

RQC domain-containing protein( domain architecture ID 10658875)

RQC domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RQC smart00956
This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix ...
 10-103 2.31e-29

This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; The RQC domain, found only in RecQ family enzymes, is a high affinity G4 DNA binding domain.


:

Pssm-ID: 214936 [Multi-domain]  Cd Length: 92  Bit Score: 102.55  E-value: 2.31e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2AXL_A          10 DFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQ-YRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEvsrYNK 88
Cdd:smart00956   1 DVTEEAQKLLSCVYRTGQRFGAGHVIDVLRGSKNKKIRQKgHDRLSTFGIGKDLSKKEWRRLIRQLIAEGYLRE---DGG 77

                           90
                   ....*....|....*
2AXL_A          89 FMKICALTKKGRNWL 103
Cdd:smart00956  78 RYPYLKLTEKARPVL 92
 
Name Accession Description Interval E-value
RQC smart00956
This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix ...
 10-103 2.31e-29

This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; The RQC domain, found only in RecQ family enzymes, is a high affinity G4 DNA binding domain.


Pssm-ID: 214936 [Multi-domain]  Cd Length: 92  Bit Score: 102.55  E-value: 2.31e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2AXL_A          10 DFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQ-YRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEvsrYNK 88
Cdd:smart00956   1 DVTEEAQKLLSCVYRTGQRFGAGHVIDVLRGSKNKKIRQKgHDRLSTFGIGKDLSKKEWRRLIRQLIAEGYLRE---DGG 77

                           90
                   ....*....|....*
2AXL_A          89 FMKICALTKKGRNWL 103
Cdd:smart00956  78 RYPYLKLTEKARPVL 92
RQC pfam09382
RQC domain; This DNA-binding domain is found in the RecQ helicase among others and has a ...
 5-103 7.19e-18

RQC domain; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure. The RQC domain, found only in RecQ family enzymes, is a high affinity G4 DNA binding domain.


Pssm-ID: 462780 [Multi-domain]  Cd Length: 108  Bit Score: 73.34  E-value: 7.19e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2AXL_A          5 EDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLAdQYRRHSL--FGTGKDQTESWWKAFSRQLITEGFL-V 81
Cdd:pfam09382   1 PPETVDVTEEAQKILSCVYRTGQRFGAGHLIDVLRGSKNKKIR-QLGHDKLstFGIGKDLSKKEWRRIIRQLIAEGYLeV 79

                          90       100
                  ....*....|....*....|..
2AXL_A         82 EVSRYNkfmkICALTKKGRNWL 103
Cdd:pfam09382  80 DIEFYS----VLKLTPKAREVL 97
RecQ COG0514
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
9-79 1.86e-11

Superfamily II DNA helicase RecQ [Replication, recombination and repair];


Pssm-ID: 440280 [Multi-domain]  Cd Length: 489  Bit Score: 60.15  E-value: 1.86e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
2AXL_A        9 WDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQ-YRRHSLFGTGKDQTESWWKAFSRQLITEGF 79
Cdd:COG0514 405 FDGTEAAQKALSCVYRTGQRFGAGHVIDVLRGSKNEKIRQFgHDKLSTYGIGKDLSDKEWRSVIRQLLAQLF 476
PRK11057 PRK11057
ATP-dependent DNA helicase RecQ; Provisional
 15-80 6.23e-10

ATP-dependent DNA helicase RecQ; Provisional


Pssm-ID: 182933 [Multi-domain]  Cd Length: 607  Bit Score: 55.87  E-value: 6.23e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
2AXL_A        15 AFKLLSAVDILGEKFGIGLPILFLRGSNSQRLAD-QYRRHSLFGTGKDQTESWWKAFSRQLITEGFL 80
Cdd:PRK11057 416 AQKALSCIYRVNQRFGMGYVVEVLRGANNQRIRDyGHDKLKVYGIGRDKSHEHWVSVIRQLIHLGLV 482
 
Name Accession Description Interval E-value
RQC smart00956
This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix ...
 10-103 2.31e-29

This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; The RQC domain, found only in RecQ family enzymes, is a high affinity G4 DNA binding domain.


Pssm-ID: 214936 [Multi-domain]  Cd Length: 92  Bit Score: 102.55  E-value: 2.31e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2AXL_A          10 DFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQ-YRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEvsrYNK 88
Cdd:smart00956   1 DVTEEAQKLLSCVYRTGQRFGAGHVIDVLRGSKNKKIRQKgHDRLSTFGIGKDLSKKEWRRLIRQLIAEGYLRE---DGG 77

                           90
                   ....*....|....*
2AXL_A          89 FMKICALTKKGRNWL 103
Cdd:smart00956  78 RYPYLKLTEKARPVL 92
RQC pfam09382
RQC domain; This DNA-binding domain is found in the RecQ helicase among others and has a ...
 5-103 7.19e-18

RQC domain; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure. The RQC domain, found only in RecQ family enzymes, is a high affinity G4 DNA binding domain.


Pssm-ID: 462780 [Multi-domain]  Cd Length: 108  Bit Score: 73.34  E-value: 7.19e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2AXL_A          5 EDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLAdQYRRHSL--FGTGKDQTESWWKAFSRQLITEGFL-V 81
Cdd:pfam09382   1 PPETVDVTEEAQKILSCVYRTGQRFGAGHLIDVLRGSKNKKIR-QLGHDKLstFGIGKDLSKKEWRRIIRQLIAEGYLeV 79

                          90       100
                  ....*....|....*....|..
2AXL_A         82 EVSRYNkfmkICALTKKGRNWL 103
Cdd:pfam09382  80 DIEFYS----VLKLTPKAREVL 97
RecQ COG0514
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
9-79 1.86e-11

Superfamily II DNA helicase RecQ [Replication, recombination and repair];


Pssm-ID: 440280 [Multi-domain]  Cd Length: 489  Bit Score: 60.15  E-value: 1.86e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
2AXL_A        9 WDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQ-YRRHSLFGTGKDQTESWWKAFSRQLITEGF 79
Cdd:COG0514 405 FDGTEAAQKALSCVYRTGQRFGAGHVIDVLRGSKNEKIRQFgHDKLSTYGIGKDLSDKEWRSVIRQLLAQLF 476
PRK11057 PRK11057
ATP-dependent DNA helicase RecQ; Provisional
 15-80 6.23e-10

ATP-dependent DNA helicase RecQ; Provisional


Pssm-ID: 182933 [Multi-domain]  Cd Length: 607  Bit Score: 55.87  E-value: 6.23e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
2AXL_A        15 AFKLLSAVDILGEKFGIGLPILFLRGSNSQRLAD-QYRRHSLFGTGKDQTESWWKAFSRQLITEGFL 80
Cdd:PRK11057 416 AQKALSCIYRVNQRFGMGYVVEVLRGANNQRIRDyGHDKLKVYGIGRDKSHEHWVSVIRQLIHLGLV 482
PLN03137 PLN03137
ATP-dependent DNA helicase; Q4-like; Provisional
 15-132 8.77e-03

ATP-dependent DNA helicase; Q4-like; Provisional


Pssm-ID: 215597 [Multi-domain]  Cd Length: 1195  Bit Score: 35.26  E-value: 8.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2AXL_A         15 AFKLLSAVDILGEKFGIGLPILFLRGSNSQRLadQYRRH---SLFGTGKDQTESWWKAFSRQLITEGFLVE-VSRYNKFM 90
Cdd:PLN03137  880 ARQLVELVKLTGERFSSAHILEVYRGSLNQYV--KKHRHetlSLHGAGKHLSKGEASRILHYLVTEDILAEdVKKSDLYG 957

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
2AXL_A         91 KICALTKKGRNWLHKANTESQSLIL----------QANEELCPKKLLLPSSK 132
Cdd:PLN03137  958 SVSSLLKVNESKAYKLFSGGQTIIMrfpssvkaskPSKFEATPAKGPLTSGK 1009
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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