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Conserved domains on  [gi|48425210|pdb|1PN2|A]
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Chain A, Peroxisomal hydratase-dehydrogenase-epimerase

Protein Classification

MaoC family dehydratase( domain architecture ID 11973509)

MaoC family dehydratase similar to Arabidopsis thaliana peroxisomal enoyl-CoA hydratase 2, which catalyzes a hydration step in peroxisomal beta-oxidation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HDE_HSD cd03448
HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), ...
 157-273 1.03e-61

HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit.


:

Pssm-ID: 239532 [Multi-domain]  Cd Length: 122  Bit Score: 190.89  E-value: 1.03e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PN2_A      157 PKRAPDYQVDVPVSEDLAALYRLSGDRNPLHIDPNFAKGAKFPKPILHG*CTYGLSAKALIDKFG*-----FNEIKARFT 231
Cdd:cd03448   1 PDRAPDAVVEIPTSPDQALLYRLSGDYNPLHIDPAFAKAAGFPRPILHGLCTYGFAARAVLEAFADgdparFKAIKVRFS 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
1PN2_A      232 GIVFPGETLRVLAWKEsDDTIVFQTHVVDRGTIAINNAAIKL 273
Cdd:cd03448  81 SPVFPGETLRTEMWKE-GNRVIFQTKVVERDVVVLSNGAALL 121
PLN02864 super family cl28571
enoyl-CoA hydratase
 9-262 3.69e-50

enoyl-CoA hydratase


The actual alignment was detected with superfamily member PLN02864:

Pssm-ID: 178455 [Multi-domain]  Cd Length: 310  Bit Score: 167.65  E-value: 3.69e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PN2_A         9 FDDRDVILYNIALGATT------KQLKYVYEND--SDFQVIPTFGHLITFnsgKSQNSFAKLLR--NFNP*LLLHGEHYL 78
Cdd:PLN02864  25 YTERDVALYALGVGACGrdavdeDELKYVYHRDgqQFIKVLPTFASLFNL---GSLDGFGLDLPglNYDPSLLLHGQQYI 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PN2_A        79 KVHSwPPPTEGEIKTTFEPIATTPKGTNVVIVHGSKSVDNKSGELIYSNEATYFIRNCQADNK-----VYADRPAFATNQ 153
Cdd:PLN02864 102 EIYK-PIPSSASVRNKVSIAGLHDKGKAAILELETLSYEKDSGELLCMNRSTIFLRGAGGFSNssqpfSYSNYPTNQVSA 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PN2_A       154 FLAPKRAPDYQVDVPVSEDLAALYRLSGDRNPLHIDPNFAKGAKFPKPILHG*CTYGLSAKALIDKF--G*FNEIK---A 228
Cdd:PLN02864 181 VKIPKSQPDAVFEDQTQPSQALLYRLSGDYNPLHSDPMFAKVAGFTRPILHGLCTLGFAVRAVIKCFcnGDPTAVKtisG 260

                        250       260       270
                 ....*....|....*....|....*....|....
1PN2_A       229 RFTGIVFPGETLRVLAWKESdDTIVFQTHVVDRG 262
Cdd:PLN02864 261 RFLLHVYPGETLVTEMWLEG-LRVIYQTKVKERN 293
 
Name Accession Description Interval E-value
HDE_HSD cd03448
HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), ...
 157-273 1.03e-61

HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit.


Pssm-ID: 239532 [Multi-domain]  Cd Length: 122  Bit Score: 190.89  E-value: 1.03e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PN2_A      157 PKRAPDYQVDVPVSEDLAALYRLSGDRNPLHIDPNFAKGAKFPKPILHG*CTYGLSAKALIDKFG*-----FNEIKARFT 231
Cdd:cd03448   1 PDRAPDAVVEIPTSPDQALLYRLSGDYNPLHIDPAFAKAAGFPRPILHGLCTYGFAARAVLEAFADgdparFKAIKVRFS 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
1PN2_A      232 GIVFPGETLRVLAWKEsDDTIVFQTHVVDRGTIAINNAAIKL 273
Cdd:cd03448  81 SPVFPGETLRTEMWKE-GNRVIFQTKVVERDVVVLSNGAALL 121
PLN02864 PLN02864
enoyl-CoA hydratase
 9-262 3.69e-50

enoyl-CoA hydratase


Pssm-ID: 178455 [Multi-domain]  Cd Length: 310  Bit Score: 167.65  E-value: 3.69e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PN2_A         9 FDDRDVILYNIALGATT------KQLKYVYEND--SDFQVIPTFGHLITFnsgKSQNSFAKLLR--NFNP*LLLHGEHYL 78
Cdd:PLN02864  25 YTERDVALYALGVGACGrdavdeDELKYVYHRDgqQFIKVLPTFASLFNL---GSLDGFGLDLPglNYDPSLLLHGQQYI 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PN2_A        79 KVHSwPPPTEGEIKTTFEPIATTPKGTNVVIVHGSKSVDNKSGELIYSNEATYFIRNCQADNK-----VYADRPAFATNQ 153
Cdd:PLN02864 102 EIYK-PIPSSASVRNKVSIAGLHDKGKAAILELETLSYEKDSGELLCMNRSTIFLRGAGGFSNssqpfSYSNYPTNQVSA 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PN2_A       154 FLAPKRAPDYQVDVPVSEDLAALYRLSGDRNPLHIDPNFAKGAKFPKPILHG*CTYGLSAKALIDKF--G*FNEIK---A 228
Cdd:PLN02864 181 VKIPKSQPDAVFEDQTQPSQALLYRLSGDYNPLHSDPMFAKVAGFTRPILHGLCTLGFAVRAVIKCFcnGDPTAVKtisG 260

                        250       260       270
                 ....*....|....*....|....*....|....
1PN2_A       229 RFTGIVFPGETLRVLAWKESdDTIVFQTHVVDRG 262
Cdd:PLN02864 261 RFLLHVYPGETLVTEMWLEG-LRVIYQTKVKERN 293
MaoC_dehydratas pfam01575
MaoC like domain; The maoC gene is part of a operon with maoA which is involved in the ...
 156-269 3.38e-37

MaoC like domain; The maoC gene is part of a operon with maoA which is involved in the synthesis of monoamine oxidase. The MaoC protein is found to share similarity with a wide variety of enzymes; estradiol 17 beta-dehydrogenase 4, peroxisomal hydratase-dehydrogenase-epimerase, fatty acid synthase beta subunit. Several bacterial proteins that are composed solely of this domain have (R)-specific enoyl-CoA hydratase activity. This domain is also present in the NodN nodulation protein N.


Pssm-ID: 396243 [Multi-domain]  Cd Length: 123  Bit Score: 128.23  E-value: 3.38e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PN2_A        156 APKRAPDYQVDVPVSEDLAALYRL-SGDRNPLHIDPNFAKGAKFPKPILHG*CTYGLSAKALIDKFG*-----FNEIKAR 229
Cdd:pfam01575   5 APGEPPDTEKPRTVTEADIALFALvSGDHNPIHVDPEFAKKAGFGGPIAHGMLTLAIVAGLVEEWGGDnviarFGEIKVR 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
1PN2_A        230 FTGIVFPGETLRVLAWKEsDDTIVFQTHVVDRGTIAINNA 269
Cdd:pfam01575  85 FTKPVFPGDTLRTEAEVV-GKRDGRQTKVVEVTVEVTEVA 123
MaoC COG2030
Acyl-CoA dehydratase PaaZ [Lipid transport and metabolism];
167-266 2.33e-15

Acyl-CoA dehydratase PaaZ [Lipid transport and metabolism];


Pssm-ID: 441633 [Multi-domain]  Cd Length: 140  Bit Score: 71.07  E-value: 2.33e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PN2_A      167 VPVSEDLAALY-RLSGDRNPLHIDPNFAKGAKFPKPILHG*CTYGLSAKALIDKFG*FN-----EIKARFTGIVFPGETL 240
Cdd:COG2030  16 RTVTEEDIVLFaGATGDPNPIHLDEEAAAATGFGGRIAHGMLTLSLASGLLVDDLPGTAvanlgLQEVRFLRPVRVGDTL 95

                        90       100       110
                ....*....|....*....|....*....|...
1PN2_A      241 RVLAW------KESDDTIVFQTHVVD-RGTIAI 266
Cdd:COG2030  96 RARVEvlekreSKSRGIVTLRTTVTNqDGEVVL 128
PRK08190 PRK08190
bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated
 171-211 6.26e-04

bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated


Pssm-ID: 236180 [Multi-domain]  Cd Length: 466  Bit Score: 41.02  E-value: 6.26e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
1PN2_A       171 EDLAALYRLSGDRNPLHIDPNFAKGAKFPKPILHG*CTYGL 211
Cdd:PRK08190  29 DDIELFAAMSGDVNPAHLDAAYAASDGFHHVVAHGMWGGAL 69
 
Name Accession Description Interval E-value
HDE_HSD cd03448
HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), ...
 157-273 1.03e-61

HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit.


Pssm-ID: 239532 [Multi-domain]  Cd Length: 122  Bit Score: 190.89  E-value: 1.03e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PN2_A      157 PKRAPDYQVDVPVSEDLAALYRLSGDRNPLHIDPNFAKGAKFPKPILHG*CTYGLSAKALIDKFG*-----FNEIKARFT 231
Cdd:cd03448   1 PDRAPDAVVEIPTSPDQALLYRLSGDYNPLHIDPAFAKAAGFPRPILHGLCTYGFAARAVLEAFADgdparFKAIKVRFS 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
1PN2_A      232 GIVFPGETLRVLAWKEsDDTIVFQTHVVDRGTIAINNAAIKL 273
Cdd:cd03448  81 SPVFPGETLRTEMWKE-GNRVIFQTKVVERDVVVLSNGAALL 121
PLN02864 PLN02864
enoyl-CoA hydratase
 9-262 3.69e-50

enoyl-CoA hydratase


Pssm-ID: 178455 [Multi-domain]  Cd Length: 310  Bit Score: 167.65  E-value: 3.69e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PN2_A         9 FDDRDVILYNIALGATT------KQLKYVYEND--SDFQVIPTFGHLITFnsgKSQNSFAKLLR--NFNP*LLLHGEHYL 78
Cdd:PLN02864  25 YTERDVALYALGVGACGrdavdeDELKYVYHRDgqQFIKVLPTFASLFNL---GSLDGFGLDLPglNYDPSLLLHGQQYI 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PN2_A        79 KVHSwPPPTEGEIKTTFEPIATTPKGTNVVIVHGSKSVDNKSGELIYSNEATYFIRNCQADNK-----VYADRPAFATNQ 153
Cdd:PLN02864 102 EIYK-PIPSSASVRNKVSIAGLHDKGKAAILELETLSYEKDSGELLCMNRSTIFLRGAGGFSNssqpfSYSNYPTNQVSA 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PN2_A       154 FLAPKRAPDYQVDVPVSEDLAALYRLSGDRNPLHIDPNFAKGAKFPKPILHG*CTYGLSAKALIDKF--G*FNEIK---A 228
Cdd:PLN02864 181 VKIPKSQPDAVFEDQTQPSQALLYRLSGDYNPLHSDPMFAKVAGFTRPILHGLCTLGFAVRAVIKCFcnGDPTAVKtisG 260

                        250       260       270
                 ....*....|....*....|....*....|....
1PN2_A       229 RFTGIVFPGETLRVLAWKESdDTIVFQTHVVDRG 262
Cdd:PLN02864 261 RFLLHVYPGETLVTEMWLEG-LRVIYQTKVKERN 293
MaoC_dehydratas pfam01575
MaoC like domain; The maoC gene is part of a operon with maoA which is involved in the ...
 156-269 3.38e-37

MaoC like domain; The maoC gene is part of a operon with maoA which is involved in the synthesis of monoamine oxidase. The MaoC protein is found to share similarity with a wide variety of enzymes; estradiol 17 beta-dehydrogenase 4, peroxisomal hydratase-dehydrogenase-epimerase, fatty acid synthase beta subunit. Several bacterial proteins that are composed solely of this domain have (R)-specific enoyl-CoA hydratase activity. This domain is also present in the NodN nodulation protein N.


Pssm-ID: 396243 [Multi-domain]  Cd Length: 123  Bit Score: 128.23  E-value: 3.38e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PN2_A        156 APKRAPDYQVDVPVSEDLAALYRL-SGDRNPLHIDPNFAKGAKFPKPILHG*CTYGLSAKALIDKFG*-----FNEIKAR 229
Cdd:pfam01575   5 APGEPPDTEKPRTVTEADIALFALvSGDHNPIHVDPEFAKKAGFGGPIAHGMLTLAIVAGLVEEWGGDnviarFGEIKVR 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
1PN2_A        230 FTGIVFPGETLRVLAWKEsDDTIVFQTHVVDRGTIAINNA 269
Cdd:pfam01575  85 FTKPVFPGDTLRTEAEVV-GKRDGRQTKVVEVTVEVTEVA 123
R_hydratase_like cd03441
(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl ...
 171-270 1.47e-23

(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel beta-sheet wrapped around a central alpha helix, referred to as a hot dog fold. The active site lies within a substrate-binding tunnel formed by the homodimer. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and the fatty acid synthase beta subunit.


Pssm-ID: 239525 [Multi-domain]  Cd Length: 127  Bit Score: 92.71  E-value: 1.47e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PN2_A      171 EDLAALYRLSGDRNPLHIDPNFAKGAKFPKPILHG*CTYGLSAKALIDKFG*FN-----EIKARFTGIVFPGETLRVLAW 245
Cdd:cd03441  13 ADIALFARLSGDPNPIHVDPEYAKAAGFGGRIAHGMLTLSLASGLLVQWLPGTDganlgSQSVRFLAPVFPGDTLRVEVE 92

                        90       100       110
                ....*....|....*....|....*....|...
1PN2_A      246 KESDD--------TIVFQThVVDRGTIAINNAA 270
Cdd:cd03441  93 VLGKRpskgrgvvTVRTEA-RNQGGEVVLSGEA 124
MaoC COG2030
Acyl-CoA dehydratase PaaZ [Lipid transport and metabolism];
167-266 2.33e-15

Acyl-CoA dehydratase PaaZ [Lipid transport and metabolism];


Pssm-ID: 441633 [Multi-domain]  Cd Length: 140  Bit Score: 71.07  E-value: 2.33e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PN2_A      167 VPVSEDLAALY-RLSGDRNPLHIDPNFAKGAKFPKPILHG*CTYGLSAKALIDKFG*FN-----EIKARFTGIVFPGETL 240
Cdd:COG2030  16 RTVTEEDIVLFaGATGDPNPIHLDEEAAAATGFGGRIAHGMLTLSLASGLLVDDLPGTAvanlgLQEVRFLRPVRVGDTL 95

                        90       100       110
                ....*....|....*....|....*....|...
1PN2_A      241 RVLAW------KESDDTIVFQTHVVD-RGTIAI 266
Cdd:COG2030  96 RARVEvlekreSKSRGIVTLRTTVTNqDGEVVL 128
FAS_MaoC cd03447
FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes ...
 165-242 1.74e-11

FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD).


Pssm-ID: 239531 [Multi-domain]  Cd Length: 126  Bit Score: 60.37  E-value: 1.74e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PN2_A      165 VDVPVSEDLAALYRLSGDRNPLHIDPNFAKGAKFPKPILHG*CTYGlSAKALIDKFG*FNEI------KARFTGIVFPGE 238
Cdd:cd03447   7 LTITAPASNEPYARVSGDFNPIHVSRVFASYAGLPGTITHGMYTSA-AVRALVETWAADNDRsrvrsfTASFVGMVLPND 85


                ....
1PN2_A      239 TLRV 242
Cdd:cd03447  86 ELEV 89
SAV4209_like cd03453
SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot ...
 167-240 6.74e-11

SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.


Pssm-ID: 239537 [Multi-domain]  Cd Length: 127  Bit Score: 58.49  E-value: 6.74e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
1PN2_A      167 VPVS-EDLAALYRLSGDRNPLHIDPNFAKGAKFPKPILHG*CTYGLSAKALIDKFG*FNEIK---ARFTGIVFPGETL 240
Cdd:cd03453  10 PPVSrADLVRYAGASGDFNPIHYDEDFAKKVGLPGVIAHGMLTMGLLGRLVTDWVGDPGRVVsfgVRFTKPVPVPDTL 87
R_hydratase cd03449
(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA ...
 171-242 3.33e-10

(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase II, and beta-hydroxydecanoyl-ACP dehydratase, MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and the fatty acid synthase beta subunit. The active site lies within a substrate-binding tunnel formed by the (R)-hydratase homodimer. A subset of the bacterial (R)-hydratases contain a C-terminal phosphotransacetylase (PTA) domain.


Pssm-ID: 239533 [Multi-domain]  Cd Length: 128  Bit Score: 56.78  E-value: 3.33e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
1PN2_A      171 EDLAALYRLSGDRNPLHIDPNFAKGAKFPKPILHG*CTYGLSAKALIDKFG*FNEIKA----RFTGIVFPGETLRV 242
Cdd:cd03449  16 EDVELFAELSGDFNPIHLDEEYAKKTRFGGRIAHGMLTASLISAVLGTLLPGPGTIYLsqslRFLRPVFIGDTVTA 91
MaoC_like cd03446
MoaC_like Similar to the MaoC (monoamine oxidase C) dehydratase regulatory protein but ...
 179-242 1.16e-07

MoaC_like Similar to the MaoC (monoamine oxidase C) dehydratase regulatory protein but without the N-terminal PutA domain. This protein family has a hot-dog fold similar to that of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.


Pssm-ID: 239530 [Multi-domain]  Cd Length: 140  Bit Score: 50.00  E-value: 1.16e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
1PN2_A      179 LSGDRNPLHIDPNFAKGAKFPKPILHG*CTYGLsAKALIDKFG*FNEI--------KARFTGIVFPGETLRV 242
Cdd:cd03446  29 LSGDWNPIHTDAEYAKKTRFGERIAHGLLTLSI-ATGLLQRLGVFERTvvafygidNLRFLNPVFIGDTIRA 99
FkbR2 cd03451
FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved ...
 169-248 1.05e-05

FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The function of FkbR2 is unknown.


Pssm-ID: 239535 [Multi-domain]  Cd Length: 146  Bit Score: 44.50  E-value: 1.05e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PN2_A      169 VSEDLAALY-RLSGDRNPLHIDPNFAKGAKFPKPILHG*CTYGL---------SAKALIDKFg*FNEIkaRFTGIVFPGE 238
Cdd:cd03451  21 VTEADNVLFtLLTMNTAPLHFDAAYAAKTEFGRRLVNSLFTLSLalglsvndtSLTAVANLG--YDEV--RFPAPVFHGD 96

                        90
                ....*....|....
1PN2_A      239 TLR----VLAWKES 248
Cdd:cd03451  97 TLYaeseVLSKRES 110
PRK08190 PRK08190
bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated
 171-211 6.26e-04

bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated


Pssm-ID: 236180 [Multi-domain]  Cd Length: 466  Bit Score: 41.02  E-value: 6.26e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
1PN2_A       171 EDLAALYRLSGDRNPLHIDPNFAKGAKFPKPILHG*CTYGL 211
Cdd:PRK08190  29 DDIELFAAMSGDVNPAHLDAAYAASDGFHHVVAHGMWGGAL 69
PRK13693 PRK13693
(3R)-hydroxyacyl-ACP dehydratase subunit HadB; Provisional
 172-234 8.58e-04

(3R)-hydroxyacyl-ACP dehydratase subunit HadB; Provisional


Pssm-ID: 184249 [Multi-domain]  Cd Length: 142  Bit Score: 38.66  E-value: 8.58e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
1PN2_A       172 DLAALYRLSGDRNPLHIDPNFAKGAKFPKPILHG*CTYGLSA---KALIDKFG*FNEIKARFTGIV 234
Cdd:PRK13693  26 DLVNYAGVSGDLNPIHWDDEIAKVVGLDTAIAHGMLTMGLGGgyvTSWVGDPGAVTEYNVRFTAVV 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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