6N7E,7BXU,1O50,1PBJ,1XKF,3GBY,7BXU,3KH5,3KH5,2O16,1VR9,2O16,3KH5,3KH5,1XKF,6N7E,1VR9,1O50,3KXR,3KXR,3GBY,1PBJ


Conserved Protein Domain Family
CBS
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pfam00571: CBS 
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CBS domain
CBS domains are small intracellular modules that pair together to form a stable globular domain. This family represents a single CBS domain. Pairs of these domains have been termed a Bateman domain. CBS domains have been shown to bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet. CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl carrying ligands. The region containing the CBS domains in Cystathionine-beta synthase is involved in regulation by S-AdoMet. CBS domain pairs from AMPK bind AMP or ATP. The CBS domains from IMPDH and the chloride channel CLC2 bind ATP.
Links
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Statistics
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PSSM-Id: 425756
Aligned: 840 rows
Threshold Bit Score: 27.1775
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6N7E_B  19 VEDVmtPLRDCFMITGEaildFNtMSEIMESgY-----TRI-PV-F--EGeRsnIV-DLLFVKDLAFVDPD 79  human
P17115 265 VNEA--MTVGGTTLQSQ----SR-AIDAKEI-Lmkr-kiTAaPV-VdeNG-K--LT-GAINLQDFYQAGII 321 Escherichia coli K-12
Q9K9P0  68 VKEV--MSEHLVTATPD----MT-VQEAAKL-MatkqiRRL-PV-Ve-NN-R--LV-GICSLGDLAVRDSS 123 Bacillus halodurans
Q9I1S3  67 VREV--MSGELRYCFED----EE-VDHVTKN-MaqlekRRL-PV-MdrNK-R--LV-GIVSLANIATCNTD 123 Pseudomonas aeruginosa
Q6MJ98  68 VSEC--MSKGIEYCFEE----DN-LLDVGEM-MasqkiRRM-PV-IndKK-R--LV-GMLSLGDIASKARD 124 Bdellovibrio bacteriovorus
Q92U35  77 VFEF--MTVAAESCEED----DS-LLLAAQK-MhdlriRRL--VvVngKR----HAaGIVALGDISRANPE 133 Sinorhizobium meliloti
2O16_A   7 VEDM--MTRHPHTLLRT----HT-LNDAKHL-MealdiRHV-PI-VdaNK-K--LL-GIVSQRDLLAAQES 63  Vibrio cholerae
Q72AZ0   4 IADL--MTTNLFTLKRS----DS-LRDARSL-MqlariRHI-PI-VdgRG-G--FV-GLLTHRDILSATIS 60  Desulfovibrio vulgaris str. Hi...
O29009   5 VKDY--MTKNVYTLKPD----NT-VKDAIEL-VrktghDSF-PV-VddNM-R--VV-GYISAVDLLDKSPE 61  Archaeoglobus fulgidus
Q9HI81 521 VSPY--IKRGITYLRST----NN-AEEAWEVmMrn--kTTWcPI-Vd-DG-E--FK-GIVTLRSILDAYHE 576 Thermoplasma acidophilum
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