3AKY,1P3J,1ZIN,1AKE,2AK2,1UKZ,1ZAK,3ADK,1P4S,1TEV,2AK3,1UKE


Conserved Protein Domain Family
ADK

?
cd01428: ADK 
Click on image for an interactive view with Cn3D
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.
Statistics
?
PSSM-Id: 238713
Aligned: 185 rows
Threshold Bit Score: 93.0702
Created: 12-Dec-2003
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP-AMP (Ap5A)-binding site [chemical binding site]
Evidence:
  • Citation:PMID 9715904
  • Structure:Residues in close contact with Ap5A (ATP-AMP dual substrate analog), in structure 1ZIN
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                              #                                          
3AKY            7 RMVLIGPPGAGKGTQAPNLQer---fhAAHLATGDMLRSQIakg------------------------------------ 47   baker's yeast
1ZIN            2 NLVLMGLPGAGKGTQAEKIVaa---ygIPHISTGDMFRAAMkeg------------------------------------ 42   Geobacillus s...
NP_704385      31 IYILNGASGSGKDTQCRLLEkk---ynYKIICISKLLKEYKeeynken-------------------------------- 75   Plasmodium fa...
EAA17630       10 VYIINGPPGSGKDTHCVSLSkk---ynFEIITISELLKKYVkdntnkddscgk--------------------------- 59   Plasmodium yo...
T26006        515 VILVLGAPGSQKNDISRRIAqky--dgFTMLSMGDILRKKInnek----------------------------------- 557  nematode
XP_419793     931 RVCLLGTRGSGKTACARWLAdk---fgIFHIQFKEYLQELLlpktkekigldfdeepeeaddeiq--lqelqdlsqtttk 1005 chicken
T26006        171 IILFMGGPGGGKTRHAARVAdsladngLVHICMPDIIRTALgkyk----------------------------------- 215  nematode
NP_001001706   72 RICLVGPQGSGKTMCGRQLAek---lnIFHIQFEEVLQEKLllktekkvgpefeedseneqaakqeleelaiqanvkvee 148  human
NP_609263      16 VIFVLGGPGSGKVTHCDTFMqer--rgVTHINMMDLLQQYAm-------------------------------------- 55   fruit fly
NP_864217      86 LILLGGAPGSGKGTNSGFISkar-gltCEPIVVSSLLDTPEa-------------------------------------- 126  Rhodopirellul...
Feature 1                                                                                 #   #   
3AKY           48 ---------tqLGLEAKKIMDq---GGLVSDDIMVNMIKDELtnnp------------------acknGFILDGFPRTIP 97   baker's yeast
1ZIN           43 ---------tpLGLQAKQYMDr---GDLVPDEVTIGIVRERLskdd-------------------cqnGFLLDGFPRTVA 91   Geobacillus s...
NP_704385      76 ----vlneeenYFDEIEKCMId---GSLVNDQIVIEIFHKQLnkyin----------------ddkynGIIINGFPRNYE 132  Plasmodium fa...
EAA17630       60 yapgltdeekkDLENIEKCICn---GSLAPDHIVNKIFLKYFksysenseqdknseqdqapesttssnGIIINGFPRTYE 136  Plasmodium yo...
T26006        558 --------ndeMWDKVSKKMNn---GDPIPTKMCRTVLYEELhsrg------------------tsnwGYVIEGYPKSPD 608  nematode
XP_419793    1006 tddeeskqeveLTEEEEAIKAnlmdAQPLPPEILDNIVPVWWkkep------------------frstGFILDGFPRTSD 1067 chicken
T26006        216 -------dkypEWKEANEHYIr---GELIPNQLALTLLKAEMgrhp-------------------damGFFLEGYPREAR 266  nematode
NP_001001706  149 entkkqlpevqLTEEEEVIKSslmeNEPLPPEILEVILSEWWlkep------------------irstGFILDGFPRYPE 210  human
NP_609263      56 ----------gNDMQDFSQLS----SKTVTEVLMLEMKMAPAa------------------------kAYLISGYPRSMR 97   fruit fly
NP_864217     127 ----------rRIKEAGGMVG----DTEVVGILFRKLLEEEYr------------------------dGCILDGFPRTRV 168  Rhodopirellul...
Feature 1                                                             #                           
3AKY           98 QAEKLDQMlkeqgtpLEKAIELKVD-----------------DELLVARITGRlihpasgrsyhkifnp----------- 149  baker's yeast
1ZIN           92 QAEALETMladigrkLDYVIHIDVR-----------------QDVLMERLTGRricrncgatyhlifhp----------- 143  Geobacillus s...
NP_704385     133 QALLIIQNni----sITKFINIQVG-----------------KDTLWTRINNRiidpitnisyneniiqiikkkregqel 191  Plasmodium fa...
EAA17630      137 QALLFKKYki----nVTKFINIVVS-----------------RETLLNRIMNRtkdpvtninynlqivklikkkkqgikl 195  Plasmodium yo...
T26006        609 QLVDLEHSlq----rTDLAILIDCT-----------------EQFCLEVINKRnre------------------------ 643  nematode
XP_419793    1068 EAQYLSERgl----cPDAAVYIHVE-----------------ESEILDRLLPPrlkkwkerqhkkae------------- 1113 chicken
T26006        267 QVEDFERQvk----sVNMALILDYD-----------------ERTLREHMERRglgme---------------------- 303  nematode
NP_001001706  211 EAQFLGDRgf----fPDAAVFIQVD-----------------DQDIFDRLLPAqiekwk--------------------- 248  human
NP_609263      98 DVVEYSEKiq----vVNGVILISWR-----------------QSVLQKQIDYGa-------------------------- 130  fruit fly
NP_864217     169 QVECLHLLiqk-mnqLYREYHSTPLainfrkptvhavvlfidEKTSIERQLLRgrkiaehnerv---------------- 231  Rhodopirellul...
Feature 1                                                    #   #                                
3AKY          150 ------------pkedmkddvtgealvqRSDDNA----DALKKRLAAYHAQTEPIVDFykk------------------- 194  baker's yeast
1ZIN          144 ------------pakpgvcdkcggelyqRADDNE----ATVANRLEVNMKQMKPLVDFyeq------------------- 188  Geobacillus s...
NP_704385     192 sdkeqkqliidnhlynnlsndilerltkRKDDEE----QVFNKRFQLYIESEQKINSLfk-------------------- 247  Plasmodium fa...
EAA17630      196 -tieeeellasqddtyqnltdeiimrleRREDDNe---STFNKRYNLYKENEEKIIPLfi-------------------- 251  Plasmodium yo...
T26006        644 --------------------------nkRSDDDS----DAVRSRMEYFKKNTLPMLKTldd------------------- 674  nematode
XP_419793    1114 ---------------ikkklkdlkakikVLEDGEn--yETSEEEDETANEDIEAILEEeffeee--------------ee 1162 chicken
T26006        304 ------------------------iidqKIKEFK----QKTLPSAKYFDDQKLLHLIPgekddq-------------viy 342  nematode
NP_001001706  249 -----------------------lkqkkKLERKKlikdMKAKIRVDTIAKRRAELILErdkkrrevssfvfffktgshsv 305  human
NP_609263     131 ----------------------------KLGHVVl---SLAKMELENFFKNVMPVADYfdq------------------- 160  fruit fly
NP_864217     232 -----------------etendgeplelRLTDLDp---TAAKRRYRVFKEKTWDALQSlkk------------------- 272  Rhodopirellul...
Feature 1                                         
3AKY          195 -tgIWAGVDAs---------------qPPATV 210  baker's yeast
1ZIN          189 -kgYLRNINGe---------------qDMEKV 204  Geobacillus stearothermophilus
NP_704385     248 --nICKNVDGe---------------kSINDI 262  Plasmodium falciparum 3D7
EAA17630      252 --dICKNVDGe---------------nDINYN 266  Plasmodium yoelii yoelii
T26006        675 -kgKLRVVRHthvmv--------dgdaDPDTV 697  nematode
XP_419793    1163 epeEEQEIDAvermqneiverfdsereSIEGV 1194 chicken
T26006        343 ekmKALVVKAletgvp------vlaalPPMAA 368  nematode
NP_001001706  306 aqgRVQWHNHsslqpr------tpglkGSSHL 331  human
NP_609263     161 -sdMLLAVNGe---------------rAPTEV 176  fruit fly
NP_864217     273 -iyHYHFIDAg---------------gDIAEV 288  Rhodopirellula baltica SH 1

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap