Conserved Protein Domain Family
Vta1_C
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pfam18097: Vta1_C 
Vta1 C-terminal domain
This is the C-terminal domain of Vta1 proteins pfam04652. Structural and functional analysis indicate that this C-terminal domain promotes the ATP-dependent double ring assembly of Vps4. Furthermore, it has been shown that it is necessary and sufficient for protein dimerization. Mutations in Lys-299 and Lys-302 completely abolished the ability of Vta1 to stimulate the ATPase activity of Vps4 while mutation in Lys-322 had no effect.
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Statistics
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PSSM-Id: 465647
Aligned: 13 rows
Threshold Bit Score: 49.2003
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WGS:AATM:SJAG_04047 269 TERIDQARRHSKFAYSALDYDDIETAISHLRSALSLLE 306
XP_005841985        288 PRSLDKAEKHTKFALSAIQFDDIREAVSNLQIALSLLT 325
XP_010763161        393 EDAIAKAQKHARWAVSALNFDDVQTAIKELTNALNMLG 430
EGW32443            334 DDTITQVQKHAKFSISALQFEDFDEAEKQLKQGLELLQ 371
GAC96328            536 AKLSTRVQKLAKGAASAVDFEDLDTARIQLRQALDILE 573
1_pfamImport          1 EEEFAEVRKFAKYAVSAIDYEDVNAIRENLLKALAVLQ 38 
KIO08602            384 PSMVAMAQKHCRFAISSLDYEDVEQARKELLVALDLLG 421
VDL89966            149 PKISALAIKHAKYAISALDYDDRTTAIQNLQEALKYLT 186
Q4QJC8              325 VDQMIDAQKLASQAVSALQFYDYENAKQQLVASLRVLN 362 Leishmania major
EGC38560            540 EDQKSDAQKYAKWVVSSLQFDDAQSAIKNLKLSYKLLT 577
EDQ86375            339 SRDIDQAKLAFKYANSALQYQDVKTAVEYCLRALTLMT 376
2_pfamImport          1 PQVMQEAEKLCKHAASALQFDDVPGAISLLEKSLKLLR 38 
XP_016091092        103 pEDFTRAQKYCKYAGSALQYEDVGTAIQNLQKALKLLT 140 Sinocyclocheilus grahami
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