Conserved Protein Domain Family
Bap31_Bap29_C

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pfam18035: Bap31_Bap29_C 
Bap31/Bap29 cytoplasmic coiled-coil domain
Bap31 is a polytopic integral protein of the endoplasmic reticulum membrane and a substrate of caspase-8. Bap31 is cleaved within its cytosolic domain, generating pro-apoptotic p20 Bap31. This entry represents the cytoplasmic domain which forms a heterodimeric coiled-coil with Bap29. This Bap29 and Bap31 are homologous to each other and this entry includes both proteins.
Statistics
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PSSM-Id: 465623
Aligned: 50 rows
Threshold Bit Score: 42.6475
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFX80917     171 EKISNLQK---ELA----EAKkersqavKDLEAFKSQSEGVAREYDRLAEEHSKLVkklavleGEGGSDKKDD 236
XP_004345792 156 KENETLTQ---KLK----ESEeakrkalVNVDNLVEQAKRNQAALDRHFEERQQEAq-----sSAPAERKKDK 216
EPB84621     161 DKIKSLQSevvQLQ----SKK-------SEYENLKQKIDQEAADYHKLADERTKL------------NPTSTI 210
XP_004923642 168 TQILNLEK---ELS----KEK-------KDKEAVKSQAEGLNKEYDRLAEEHSKLQkkl--tvSGEGDSKKDE 224
EDV96047     173 ERVQELTS---DLN----REK-------KDKEAVKSQAESLNREYDRLTEEYSKLQkqi--tiGAVGKADKDE 229
XP_008206250 175 AKLKELES---ELE----KEK-------KDKAAVKSQAESLAKEYDRLNEEHSKL--------LSAGGDKKSD 225
XP_006558287 173 NQIKELQTknkELEdqviKEK-------KDKETIKSQAESLAKEYDRLNDEHSKC--------LQSSGDKKSD 230
XP_011143389 177 NQIKELQAknlELEndliKER-------KDKEAMKSQADSLAKEYDRLNNEHAKI--------AQSSGDKKSD 234
XP_015788247 189 SELAGIKE---ELI----KSKne----lAKAEAVKKQAEGISREYDRLAEEHEKLIk-----kMGMAGDKKGD 245
XP_019855950 175 TRITELEK---EVKkv-----------lADRDAMRKQAESLHAEYDRLSGEYQKIQk-----eQDGEEDKKEQ 228
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