Conserved Protein Domain Family
LIP1
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pfam15904: LIP1 
LKB1 serine/threonine kinase interacting protein 1
LIP1 is a protein found in eukaryotes. It represents the N-terminus of a leucine-rich-repeat protein that is implicated in Peutz-Jeghers syndrome. LIP1 interacts with the TGF-beta-regulated transcription factor SMAD4 to form a LKB1-LIP1-SMAD4 ternary complex. Mutations in SMAD4 lead to juvenile polyposis, suggesting a mechanistic link between these two diseases.
Links
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Statistics
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PSSM-Id: 464931
Aligned: 6 rows
Threshold Bit Score: 126.837
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_001962711    1 MDPQK-ITELANLLRQNGDKILSSEFTLTLSGSLLRALNDSFTLIADTEvSHDQGFQVVKPINAKSSVFPDLQLLHDFVQ 79  
XP_011482066    6 SGQSSlVHSLATLLRNNGDVVLDGSSTLTLPAASLQQLTRLFEQHLLPR-SHQHGFLALPSHPADTVSLLELQFLFDILQ 84  
XP_011604678    6 SSQCPlVHSLAKLLRNDGDLVLDGSSTLTLTASSLQQLTRMFEQYLLPR-SKQHGFLALPSHPADTASLLQLQFLFDVLQ 84  
XP_008110022    5 APKEImLKSLAQLLQDSGDLILDGTSTLTLFTSTLQILTEIFEQHLLPR-NQNHGFIALSSHPAETSAILQAQFLFDVLQ 83  
Q5F479          7 AAAEPlVSGLARLLQDTGDLVLDGSSTLTLLTPTLQHLTRVFEQHLGSR-NQHRGFVALPSHPAETTAILQAQFLFDMLQ 85   chicken
XP_006636762    6 SGGSTlVHSLASLLRNNGDSVLDGTSTLSLMASSLQHLTRLFEQYLLSR-THQHGFLALPSHPADTASLLQVQFLFDMLQ 84   spotted gar

XP_001962711   80 KTTLLKLTHFP 90  
XP_011482066   85 KTVSLKLINPP 95  
XP_011604678   85 KTISLKLINPP 95  
XP_008110022   84 KTLSLKLIHVP 94  
Q5F479         86 KTHSLKLIHVP 96   chicken
XP_006636762   85 KTISLKarlac 95   spotted gar
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