Conserved Protein Domain Family
Nudc_N

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pfam14050: Nudc_N 
N-terminal conserved domain of Nudc.
The N-terminus of nuclear distribution gene C homolog (NUDC) proteins contains a highly conserved region consisting of a predicted three helix bundle. In the human homolog this segment has been targeted for structure determination by the Joint Center for Structural Genomics. NUDC forms a complex with other NUD proteins and is involved in several cellular division activities. Recently it was shown that NUDC regulates platelet-activating factor (PAF) acetylhydrolase with PAF being a pro-inflammatory secondary lipidic messenger.
Statistics
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PSSM-Id: 464073
Aligned: 32 rows
Threshold Bit Score: 65.2786
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDL47459       5 KHENMLLAIAR-DFQSIDNLIETFFSFLEHKTDYFHVMLNED-------DigtlakkyegtlekdilnnnKC----GFKA 72 
Q4UH66         7 GVDNLLLLLTQ-RSGGVEKLLENFFSFLARKTDFY-----------------------------------------RPPD 44  Theileria annulata
XP_001611385   7 ETDHIMFMLIE-HCKGIEDLLDTVFEFLGRRSDFFDYGVDDD------------------------------------PN 49 
XP_001611469   3 EFNNVMHMAAR-NFNNIEELLDAFFGFLCTQTDFYHTQISDEqmkkygiD--------------------KTvnqrGFKP 61 
Q4UCB0         4 NFDEFMFMALK-ECKGIEDVLEKFFSFLRRRTDFCHTVLTPEqlkefglD--------------------DSvnsrGFRP 62  Theileria annulata
CBN79652       7 KFDDVLRNLAG-QAGSLEALLGAFFSFLHRNTDFYVTFDPTKta------------------------raGM----GFPA 57 
EED96259      22 HFEAPLIALANlSGGDLRKLFYAFFSFLNRRTDFYCILPDDG-------Sgas---------------grNM----GFKE 75 
EEC46781      39 GTDALLISLANrCGGDLRQLLFVFFSFLNRRTDFYLVPHEDD-------Qkeg---------------kaRM----GFQE 92 
ESS34367      14 VHEELLLNLAR-HHPDIESLLQTFFDFLERRTDFFHVIESSGasaglesP--------------------NM----GFRE 68 
Q8IAW7         5 KHENMLMAIAR-DFNSVDDLIETFLTFLENKTDYFHVMLNDK-------DvetlsekydgailknllnnnNC----GFKA 72  Plasmodium falc...
EDL47459      73 HSREQNLMKSFR 84 
Q4UH66        45 KTSESSLDHCVN 56  Theileria annulata
XP_001611385  50 QHLEKCVKLVMR 61 
XP_001611469  62 GYIKELIMHIND 73 
Q4UCB0        63 NQMRDLVNKIIE 74  Theileria annulata
CBN79652      58 GKAEKLLLRAFR 69 
EED96259      76 GQAEQILIASFR 87 
EEC46781      93 GDAEKVLLASFR 104
ESS34367      69 GRAEAMVRQAFS 80 
Q8IAW7        73 HSREQLLIKSFR 84  Plasmodium falciparum 3D7
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