Conserved Protein Domain Family
NRDE-2

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pfam08424: NRDE-2 
NRDE-2, necessary for RNA interference
This is a family of eukaryotic proteins. Eukaryotic cells express a wide variety of endogenous small regulatory RNAs that regulate heterochromatin formation, developmental timing, defence against parasitic nucleic acids, and genome rearrangement. Many small regulatory RNAs are thought to function in nuclei, and in plants and fungi small interfering (si)RNAs associate with nascent transcripts and direct chromatin and/or DNA modifications. This family protein, NRDE-2, is required for small interfering (si)RNA-mediated silencing in nuclei. NRDE-2 associates with the Argonaute protein NRDE-3 within nuclei and is recruited by NRDE-3/siRNA complexes to nascent transcripts that have been targeted by RNA interference, RNAi, the process whereby double-stranded RNA (dsRNA) directs the sequence-specific degradation of mRNA.
Statistics
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PSSM-Id: 462472
Aligned: 100 rows
Threshold Bit Score: 179.828
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KJE91902      587 RLNEFVRLHPRNVDGWMRLVEFQE-TLLslhsggfasffqqSaqttgksqatgkaqAWnrssapRMA--VAEMQLAILER 663 
XP_005047498  318 EYNKKVRENPRDINAWMEFISFQD-ELMrgpgpy--askgeQes----------rrKS------LKL--ILEKKLAILER 376 
XP_015205763  312 EYNRRLRENPADVQTWMEFVRFQD-ELMagpsaf-smtesdSdk----------gkRS------LRV--TVEKKVSILER 371 
XP_023208489  324 EFNRRLREQPADTQLWIEFIRYQD-ELSaaafgg--geeqqGs------------dLAerrkssYRA--ILEKKLSIADR 386 
XP_005158613  299 EFNRNLRENPTDIKLWLDFVHFQD-ELAfgsgsfssagdcdAem----------rkMS------LRA--VLEKKLSIMDR 359 
XP_003385086  315 DYNRRL-AGTNDVSLWLEFIAFQD-QLLhwgvspsgdgedkGvgee-------rkkKL------KAA--ITERKISIYEK 377 
A0DU55        113 ELQNQLQTNVNDLDIWKEFLLIQEkIAElqg------------------------------ynePLL--LANRRLSILQK 160  Paramecium te...
EFA79562      338 ELNSAVERSPNDIDRWIELADYQD-----------------Hf------------lVFstkrsqRARipIVEKKLSIYRS 388 
XP_003292652  344 ELNYKVEQNPTDIDRWLDLVKFQE-----------------Nf------------qQFsak-ksRSKfsMYDRQLTIYKN 393 
Q54QP0        356 ELNKLVEQYPNNIEYWIDLVKFQE-----------------Nf------------qQFsrn-vnKSKtsMYEKQLSIYRN 405  Dictyostelium...
KJE91902      664 ALREN---PASPELARRYLSLGHEL-WPSA---K-LAEQWERIIF-------------------QFS-THLVMWREYLLF 715 
XP_005047498  377 AIESN---PSNVDLKLARLKLCAEF-WEPP---A-LIKEWQKLIF-------------------LHP-NNPEMWKKYLLF 428 
XP_015205763  372 AIESS---PGSVELKLARLELCQEL-WEPS---T-LLKEWKKLIF-------------------LHP-NNTELWRKYLVF 423 
XP_023208489  387 AVETN---PTCVALQLERLRICQDL-WEPS---T-LAKEWKKLVF-------------------LHP-NSAPLWRKYLLF 438 
XP_005158613  360 AVESN---PSDVDLKLEKLRLCKEL-WEPA---V-LQKEWKKLVF-------------------IHP-NSAPLWKKYLLF 411 
XP_003385086  378 ALGIF---PYSTDLIIGHMELVEEI-WDTE---K-LVEKWKDIVF-------------------YNS-NQSLLWIKYIEF 429 
A0DU55        161 LEQVSevlADHPWVLAYKISLMQNLeLRNDelhKeIDNCWSELFS-------------------KYV-HIQPIWILFLDH 220  Paramecium te...
EFA79562      389 ALAMN---PDSDELTIRYLRLAQEI-WDSE---Q-VRQLWSRVIErrsleysa---assssssnVDDlISEDLWREYTSF 457 
XP_003292652  394 ALMAN---PDSERLTIEYLKLASEI-WDQE---R-VLNLWNALIQkstqdfldyqqqvhsqhqaHPTiISEDLWREYINF 465 
Q54QP0        406 SLLHN---PDSEILTIEYLKLASKL-WDQQ---K-VLDLWNKVLSsss-------------sssSSSiISEKLWKEYIEF 464  Dictyostelium...
KJE91902      716 CQSHVATFSMATCLSGYRKCFSTLSGINERTIReTLAvAetaaptlaaatiaiQRDLLDITSQLCDFLRDSGCPEKAVAL 795 
XP_005047498  429 CQSQFTTFSVSKINSLYGKCLTTLAAVQDGSMVsHPLlPg------------tEEAMLAIFIQQCHFLRQAGHSEKAVSL 496 
XP_015205763  424 SQSQFSTFSVLKVNGVYGKCLSTLAAVHDGSMVsHPAlPg------------tEEAILEMFLQQCQFLRQAGHSEKALSL 491 
XP_023208489  439 TQSYFSSFSVTKVNSVYGKCLSTLSAVRDGSMVsHPAlPg------------iEEDMLDIFTQQCHFLRQSGHCEKAISL 506 
XP_005158613  412 TQSHFSTFSVSKVNGVFGKCLSTLSAVQDGSMVsHPPlPg------------tQEDLLDIFLQQCHFLRQAGHTEKAVCL 479 
XP_003385086  430 CLSRFSYFQTNSVIAIFTKSISTLTGIAERRLLsHYPeVd------------aERKILAIYVFLCYFLREAGYIERAIAT 497 
A0DU55        221 KLK-TEIFSATMLRIEANKHIANLQKLINETTRaQLVqLf-------------KRIYIELIQQIAFYESEMGFKERSVGI 286  Paramecium te...
EFA79562      458 NMSNFAVFTIGDTRQHFARLVQLLLAKRRTLKPrDHGfMasv--------gkvEEALLGFVGQWARFERHAGYTERAIGM 529 
XP_003292652  466 CLSNFNNFTVNKMKETITQVIRKLLIKRRSFKVkEKNfMerv--------qvvEESILQFLSQLTRFLHQAGYSERVVGI 537 
Q54QP0        465 CLSNFNDFKIEKIKETIITIIRKMLVKRRSFKVkDYNfMeni--------snlEESILQFISQLSKLLNQAGFSERVIGI 536  Dictyostelium...
KJE91902      796 YQALVELCWFAPTTMdpvltpSTKTTLKgllaF---FEPFWDS-SVPRFSDAGAAGWRAWHTQHVVNQtaaqhdipvsgm 871 
XP_005047498  497 FQALIDFTFFKPDSV-------KDLPTRgqveF---FEPFWDS-GEPRIGEKGARGWKAWMHQQEKGGwvikpddedd-- 563 
XP_015205763  492 FQALLDFTFFKPDSV-------KDLPTRqqveF---FEPFWDS-GEPRIGERGARGWKAWMRQQERGGwiipteadddd- 559 
XP_023208489  507 FQAMIDFSYFKPDSVkk---lSTKQQvd-------fFETFWDS-GEARVGEIGARGWKAWMTQQERGGwiq--------- 566 
XP_005158613  480 FQALLDFTFFKPDNV-------KNLATRqqvdF---FEPFWDS-GEPRIGERGARGWKAWMLQQEKGGwvippepddde- 547 
XP_003385086  498 FQALIEFSLLCPIDE------YPADGFYpriaRrkgLESFWET-DEPRFGEEGAVGWTGWEHREEVEPtplglfpsdkyd 570 
A0DU55        287 LQALCEMNLFAPKHL---------QRTYdleeKvkeFRNYWDM-NV-RTGEQNEYGWIDTP------------------- 336  Paramecium te...
EFA79562      530 YQSLIEFNCFLPVHLeranqqQQ-Ilr--------sFKLFWEA-ELPRVGESEAQGW-------LNNRvdnetqltieem 592 
XP_003292652  538 YQALIELNCFEPIALsn--epQSVLlk--------eFKEFWVSnNYAKIGESNSIGWSNAYNQILNDKinstgkndggle 607 
Q54QP0        537 YQSLIEFNCFEPIQLsn--etQATLlk--------eFKSYWSSlDYPKIGNPNSIGWSKSFTILLNNSinnnnnknnnnn 606  Dictyostelium...
KJE91902      872 rass------------------------------------------------------------ptppslsqedaefsvy 891 
XP_005047498  564 ----------------------------------------------------------------------eeidedqeik 573 
XP_015205763  560 ---------------------------------------------------------------------edaddddgevk 570 
XP_023208489  567 ------------------------------------------------------------------------------pp 568 
XP_005158613  548 ----------------------------------------------------------------------eeeqedseik 557 
XP_003385086  571 kllkesp-------------------------------------------------------kdkegeteeeeedidikf 595 
A0DU55            --------------------------------------------------------------------------------      Paramecium te...
EFA79562      593 eellreqeleeqqtiqrqqqid------------------------qqdifnlkvenkpddvdvddldneqkqqqveeve 648 
XP_003292652  608 dldnlsieeiekllkeqedlekqsel----------------nqnnnenlftinesnfneqndddinqddqdinktkesy 671 
Q54QP0        607 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnmdldnldnlsieeiekllkeqedqenqdnenifnithkskdlnedd 686  Dictyostelium...
KJE91902      892 AETLARQpverplaasqsadgrtvD--------LWLNAELKRDSHHWRPLRmppqdadtlgnlEAAATLDelieRDPEQV 963 
XP_005047498  574 DKTLPKW-----------------R--------IWLDIEYSREARHWLPWRpd---------kTKKETEEd--cEDPERQ 617 
XP_015205763  571 DRSLPKP-----------------Q--------VWLEVEASREARHWLPWRpd---------rAKGQSEEd--cEDPDRQ 614 
XP_023208489  569 AEEEEEEeeeed--------eeevKdrsqprgtVWLDVESSREAAHWLPWRpd---------kAKGQSEEd--cEDPDRQ 629 
XP_005158613  558 DKTWPKW-----------------K--------IWLDVEASREANQWLPWRpd---------kTKGQSEEd--cEDPDRQ 601 
XP_003385086  596 VSGQPLN-----------------K--------AWLKIESYRDEENSLPGRls--------apVNSKMNSd--sEDPEHI 640 
A0DU55        337 -ELKDDFigyfdlsqqiqeqedqiQ--------QFLSFQQL---KRWRPAN--------------QRFDIewieQNVDAA 390  Paramecium te...
EFA79562      649 EEGESNDkmevevevkernekkewL--------EWSEKEMESELNRWIPSRv----------lEIPDEES----HDTDRL 706 
XP_003292652  672 Knkntpes----------ihenkfI--------NWGKNEIKKDTSKWLPLNidka----tlndEMGEEND----QDTDRV 725 
Q54QP0        687 Dnennnnnqeeqedndsnsndndnnnnkfntwgkkeieldelkwkpldinnnlevnkevnendtervvlfndfyellfrf 766  Dictyostelium...
KJE91902      964 VLFEDISAFLFRITAPEIKEALLWRFVEFLG 994 
XP_005047498  618 VLFDDLGPSLIRLSDPKLQHQLLYSFLQFLG 648 
XP_015205763  615 VLFDDIGPSMIRISKPELRFQLVCSFLHFLG 645 
XP_023208489  630 VLFDDIGPSLICLTSPELQLRFLLSFLAFLG 660 
XP_005158613  602 VLFDDIGPSMIRVDRADLQAQLILAFLQFLG 632 
XP_003385086  641 TLFDDLIQIMFMMPDPELHYLLLLEFVRFLG 671 
A0DU55        391 VIYEDIEPYLYIFNDQESKLNLVSILLQQIG 421  Paramecium tetraurelia
EFA79562      707 VLFDDIKDILFRMVKDEDKLYLVYQFLEFLG 737 
XP_003292652  726 VLFNDVFDLLFKFVRDEIKIELIFQFLEFLG 756 
Q54QP0        767 vkeenklelvfqfleflgvpisllddkiqpr 797  Dictyostelium discoideum
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