6ZYY,7KZN,6ZYW


Conserved Protein Domain Family
DHC_N1

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pfam08385: DHC_N1 
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Dynein heavy chain, N-terminal region 1
Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.
Statistics
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PSSM-Id: 462457
Aligned: 195 rows
Threshold Bit Score: 266.751
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6ZYY_C    206 MQHYEMKFNEWINLISSQLNDDSEVRKDekdaGPATELIYWRSRMQKITNWSEQLKSKDFQIVKASLQRHKNhdnqrprg 285  Tetrahymena therm...
EGD73488  220 VKSLERVVLRWIKDIQQVTRLERDLSTG----SARQEIRFWLSMERALSQLKVRLAEDDVTLTLAVLREAKR-------- 287 
EHY54023  279 LNSIQNHVIGWIKSIQGVTKLAKDGPSTq--ySAAQEINFWLSLESALNKLDDERHSDGVVLTLDILKKAKR-------- 348 
ERT02584  309 LNSLQATVNTWIKSIQVITKMTQDPSTG----TANQEINYWLSMESALERIETQLRGDGVSLTLDILKHAKR-------- 376 
EOR01533  238 LNRLQNDVNSWIKEIRNVTKLNRDVASG----TASQEINFWLSMERALEGIEEQLKSEPIMLTLEILKYAKR-------- 305 
Q5KFR9    285 LNKLQADVNSWIKEIQAVTKLNRDVASG----TASQEINFWTSMEHALEGIEQQLGGEEVTLVLDVLKHAKR-------- 352  Cryptococcus neof...
KDE03481  303 LNKLQSEVNSWIKEIQNVTKLSRDVASG----TASQEINFWLAMEKALESIEEQLRSDPIVLTLDILKTAKR-------- 370 
EGU12573  274 LNKLQSEVNNWVKEVQKVTKLSRDVASG----TASQEVNFWLSMEKALEGIEKQLKSEPVQLSLDILKHAKR-------- 341 
EPB90529  263 LNRLQSDVNGWIKEIQKVTKMSRDPASG----TAIQEINFWLSMERALEKIDEQLKSDQITLTLDILKHAKR-------- 330 
EGF78727  194 LNKLQSDVNEWIKEIQKLTLLDRDPESG----SARQEIEFWIALERALNHIDLQLHSDEILLTLDTLRAAKR-------- 261 
6ZYY_C    286 deslsklmmeYNRL-----DLLLTDKLNEAKDNVKYLTTLekFIEplYn---gTPQQIIDTLPALMNAIKMIHTIArFYn 357  Tetrahymena therm...
EGD73488  288 ----------LTILksfetDTNLS-MYDTVLDYNTLMKDF--PIN--AiliatDIKKLVEAMLEVFQHM-KKVKHT-RYp 350 
EHY54023  349 ----------QQAVvsfetDTGLKDALETVRNYNTLMRDF--PLD--ElssatSLGKVAEAIVLIFNHLNKKWRVC-NYp 413 
ERT02584  377 ----------FQATvsfvaDTGLKEAMERVQKYNQLMRDF--PLD--EllsatTLAKVEDSIVQIFGHLNKKLRIC-PYp 441 
EOR01533  306 ----------FHATvsfiaDTGLKEATDIVHKYNQLMKDF--PLD--EllsatDFQKIQDSLYLIFGHINKKLKLS-PYp 370 
Q5KFR9    353 ----------FHATvsfiaDTGLKEAADLVHKHNILMKDF--PLD--EllaatDLEKIQDAIYLIFAHINKKLKLS-PYp 417  Cryptococcus neof...
KDE03481  371 ----------FHATvsfmsDTGLRGATEIVTKYNQLMKDF--PLN--EllsatDLAKVQDSLHMIFGHVNKKLKLS-PYp 435 
EGU12573  342 ----------FHATvsfiaDTGLNDAFKTVHDYNVLMKDF--PLN--EllaatDLNKIKDSINQIFLHVNKKLKLS-PYp 406 
EPB90529  331 ----------FHATvsfiaDTGLKEGMELVHKYNQLMKDF--PLN--EllsatDLDKIRESLHMIFGHLNKKLKLS-PYp 395 
EGF78727  262 ----------FHATvsflaDTGIKEKTEKVQRYNQLMKDF--PIN--DllsstDLDKIGESILLIFSHINKKFKIS-PYp 326 
6ZYY_C    358 tTDKMTGLFIKITNQMIKNCKDRILnkKdngdnpslykmIWe--qDpaELIEVLGSCIKLYCEYKKCYn----DTKekva 431  Tetrahymena therm...
EGD73488  351 -RERFIELIKAISRDVNSQLLKILS--Kk---------kLMhmpiP--EFENLYNQCNQLFREWNDKsdf-rtIIQ---- 411 
EHY54023  414 -IRRALKLVEGISEDMNEQIHNLLR--Gr---------sIMslsyD--DFSELMRSVDLIWETWDDQIksftaVAR---- 475 
ERT02584  442 -IRRALALVESISGDLDDAMHRLLP--Gt---------eLVdldyN--EFNRVMSAANGIFRAWDDVVkeftnVAR---- 503 
EOR01533  371 -IRRALPLVEAISKDFNDQMLKVLQ--Th---------rLMymeyE--SFERSINAADSAFKVWDDVLkeftnVAR---- 432 
Q5KFR9    418 -IRRTLPLVEAISSDFNDQLLKVLS--Sq---------rLMymdyT--KFEEVMATAAEVFATWDENMkdftnVAR---- 479  Cryptococcus neof...
KDE03481  436 -IRRALPLVEAISQDLNDQLLKVLG--Sq---------rLAyldyA--AFERSMSACSAVFHAWDEGLkefttVAR---- 497 
EGU12573  407 -VRRILPLVEAISRDLENQLHKVLS--Sq---------rLTyldyP--LFEQAMRAAEGVFQAWDESFkeftnVAR---- 468 
EPB90529  396 -IRRALPLVEAISRDLNDQLLKVLG--Sr---------rMMymeyD--DFERTTAGAESVFHTWDDLIkeftnVAR---- 457 
EGF78727  327 -IKRMLKLIEAISKDLNTQMLKTLS--Ss---------sIMmipwE--EFDFCIRKTDQVFRIWEEQLkefinVAR---- 388 
6ZYY_C    432 dmpkgktfDF---SDaQifgkfDTFV--------------RRLQKLIEIFSNIQQFnalakhN-----LEG--------- 480  Tetrahymena therm...
EGD73488  412 --------ELrstQRgG--------RatarrvvpehkalqERLALVHDFRLRHDDL------KqrisvVLKqrgiepd-- 467 
EHY54023  476 --------EIt--RKkN-----TDFVpvkvip--rhaktqERLRYIAQFRHNHEQL------QktivtVLGnkdgtdgas 532 
ERT02584  504 --------EVt--RRrN-----DKFIpikinp--rhaqlqARLKYIQNFRENHEQL------QrtivtVLGtkesnadga 560 
EOR01533  433 --------EVt--RKrS-----EKFLpikina--ahwklaERCAYLRNFRKQHEQLr-----------NMTatrntkagt 484 
Q5KFR9    480 --------EVs--RKrA-----EKFIsikinp--ihaklqERITYLRAFRRSHEQLr-----------VMTsstrsfsgl 531  Cryptococcus neof...
KDE03481  498 --------DVt--RKrN-----EKFIpikina--rhaalqERVGYFRQFRKQHHQLq-----------VMVgplgtevgg 549 
EGU12573  469 --------EVt--RKrG-----ERFIpikidp--ghaklqERVLYFRHFRKQHHQLq-----------VMVgplssetkr 520 
EPB90529  458 --------DVt--RKrS-----EKFLpikinp--ahaklqERVAFVRAFRKQHEQL------HqtivrVMTsprakkatv 514 
EGF78727  389 --------ELv--RKrS-----EKFLvlkins--ahvplqERLSFVHIFRRQHEDL------CstilkVIKsesasikqs 445 
6ZYY_C    481 --------------------------------MDVLTNkfkkIIDDFKkkGhNLLDTANNK---FDRDWVEFNVEISHLD 525  Tetrahymena therm...
EGD73488  468 --------------------------adednaLAEVEN----AYDEMR--SvDVLDLEEEGqraWDRACESYEARVNQVE 515 
EHY54023  533 sdkg---------------gaaiveelgdvdaVEEVSA----AYEVVR--HvDVLDVSTKGtdvWIQAEKEYTERTSRVE 591 
ERT02584  561 dtsaasngsav-vaangfggpsgfeetsdvdaVEEVRQ----AWEALR--NvDLLDVTPEGttkWVRAENTYNERTARVE 633 
EOR01533  485 gv--------------------gadnltdldmEDEVKA----AYDTLK--NvNVLDISVEGteiWIAAETAYNERVARVE 538 
Q5KFR9    532 g----------------------ndvpfdidmEEEVRL----SYENVK--NvNVLDVSPEGseiWYTAETAYNDRVARIE 583  Cryptococcus neof...
KDE03481  550 akrittgat------aeggqeryasvlndvdmDAEVKL----AYENVK--NvDVLDVSSEGteiWVTAETSYNERVARVE 617 
EGU12573  521 stavngdgakengdvdgelarewsstlgdidmEVEVRQ----AYEGIK--GiDVLDVSDDGtqiWIAAETGYNERVARVE 594 
EPB90529  515 vvdgqvk---------svieeeesvsisdinaVEEVKL----AYESVK--NiDVLDVSPEGteiWVQAETAYNERVSRVE 579 
EGF78727  446 slaptsa----------saqrtkdldleasgaQEDVVS----AFDTIR--SvNVLDLSPEGtqsWVAAENIYTERIAQVE 509 
6ZYY_C    526 GELQNFIDNNFNRFrNIEYslKLLHKFQ-St--iKRDSLKHNLTSRYNAILHNYATELDTIQRVFQDqKSn-----pPlv 597  Tetrahymena therm...
EGD73488  516 DTIIKHLCHELDHA-AKSS--DMFRIFRhYyallDRPRIRNAVRSYQKQLMSNVKDDIIELHKKFKM-QYhnsnnshMsa 591 
EHY54023  592 DSIITRLRDRLGKA-KTAN--EMFRVFEkFnpllVRPKVRGAITAYQTQLLDNVKNAIASLHERFKQ-QYggseaqmMaq 667 
ERT02584  634 NSIIARLRDRLATA-KNAN--EMFRVFSkFnalfVRPKIRGAIAEYQTQLIDNVKQAIAALHERFKQ-QYghseahaMat 709 
EOR01533  539 NQIIARLRDLLGTA-RNAS--EMFRVFGyYnalfVRPKIRGAISEYQTQLIDSVKEDIKRLHGKFTT-QYrnteafhMsq 614 
Q5KFR9    584 NQIISRLRDKLATA-RNAQ--EMFRVFSkFntlfVRPKIRGAIQEYQTRLIESVKEDIHRLRQKFTE-NYrnsqayhMsq 659  Cryptococcus neof...
KDE03481  618 NQIIARLRDRLASA-RNAN--EMFRVFSkFnalfVRPKIRGAIAEYQSELIDSVKEDIRALHDKFKR-SYaqseayhMsq 693 
EGU12573  595 NHIISRLRDRLGGA-KNAN--EMFRVFSkFnalfVRPKIRGAIAEYQSQLIDSVKDDIRRLQDKFKS-GYqsseayqMsq 670 
EPB90529  580 NQIIARLRDRLGTA-KSAN--EMFRVFSkFnalfVRPKIRGAIQEYQTQLIDSVKEDINKLHDKFKM-QYrnseayhMaq 655 
EGF78727  510 GQIISRLRDRLASA-RNAT--DMFRVFSkFnalfIRPKIRGAIHEYQTQLIERVKEDIHRLHEKFAA-QHddvemlrMvr 585 
6ZYY_C    598 rN-MPPEAGKIIWARHLFQKITGPINIFPEnvin----steiRRYYGSYNTLGKQLTiyEMWFYQDWVNKIEqskaA--- 669  Tetrahymena therm...
EGD73488  592 aRdIPPTSGQIIWMAQIERQLDDYLERVGHvlgpnwmkhvdgRELKERGETFKEKLR--QANPYDLWLQEIEt---Qdi- 665 
EHY54023  668 lRdIPPVAGAILWVRQIETQLDNYMSKVHAvlgeewmfhadgEKLQIESNMFRKKLS--TREIYQAWVQD-V----Qsrd 740 
ERT02584  710 lHdLPPVSGAIIWARQIERQLDNYMKKVEDvlgadwalhaegQKLQNESIQFRKKLK--TAPIFEAWARD-T----Mrre 782 
EOR01533  615 lRdIPPIAGAIIWAKQIERQLNMYMKRVEDvlgegwdlyaegAKLQSESTSFRKKLD--TRPIFEAWLHE-I----Nrrd 687 
Q5KFR9    660 mRdFPSVSSAIIWARQIERQLLTYMKRVEDvlgkgwesyaegHKLQMESASFRTKLD--TRPLYDAWISD-I----Tkrg 732  Cryptococcus neof...
KDE03481  694 lRdHPPVSGAIVWAKQIERQLLAYMKRVEDvlgkgwelyaegTKLQAESQSFRRKLD--TRPIYDAWLHD-I----Qrrn 766 
EGU12573  671 lRdHPPISGAIIWARQIERQLSGYMKRVEDvlgtewshyadgQRLQTESQSFRAKLS--TRPIYDAWLVD-I----Nrrn 743 
EPB90529  656 lRdLPPISGAIIWARQIDRQLSLYMKRVEDvlgkgwelyaegQKLQIESSSFRKKLD--TRLIYENWLQE-I----Tkrd 728 
EGF78727  586 lRdLMPISSSVIWARQIERQLGEYMKRVEDvlgrgweqyaegQKLSQEERAFKNQLN--TRPIFDRWVAN-I----Ssre 658 
6ZYY_C    670 ----LQAtLIVRhdeNkk----------lyVNFDLEIMQLIREAKCLDRQGi--eIPESARIILLQEDKFKTYYNELLYA 733  Tetrahymena therm...
EGD73488  666 --tfKNT-IFDIe-lFrgekt----rlemfVNFHERLITMAKEVRIMGWLKnvprVPKLAVVKAKKANMLYPYVISLKNS 737 
EHY54023  741 -isvSGR-LFAIl-rSrgang----alelsVNFDNHAISLFKEVRNLTWLNf--qVPHRITTTAKQAQRVYPYALSLMES 811 
ERT02584  783 -vsiAGR-LFSIk-rVrsagn----tlelaVNFDPQVIALFKETRNLIWLNc--sVPHAVNSVAKDAKRVYPYAVSLMES 853 
EOR01533  688 -mriEGR-LFEIs-rTrnsvtgelnvyqlsVNFDPQVITLFKEVRNLLWRQf--qVPHAIINIAKDAKRVYPHAVSLMET 762 
Q5KFR9    733 nltiTGR-LFDVi-rTratatnaqgqlqlvVQFDPQVIALFKEVRSLIWLGf--pVPLTISHKAKDAKRVYPHAVSLMES 808  Cryptococcus neof...
KDE03481  767 -lqiTGR-LFDIt-kSraqgg----llqlvVNFDAQIITLFKEVRNLVWLGf--sVPHTISNIAKDAKRVYPHAVSLMET 837 
EGU12573  744 -lqiSGR-LFNIt-kSrqqag----alqltVNFDPQIITLFKEVRNLLWLGf--qVPHTISNVAKDAKRVYPYAVSLMET 814 
EPB90529  729 -lsvSGR-IFEIt-rNrvqkn----alqlgVNFDGQIITLFKEVRNLLWLNf--qVPHTISNVAKDAKRVYPFAVSLMET 799 
EGF78727  659 -iniGGR-IFDIt-rNrargg----elqltVNFDDQIIAVFKEIRNLLWHQf--vVPHPIVNVAKDAKRVYPFAVSLAET 729 
6ZYY_C    734 LKEYERINSKIkpiCK-----NLLLPHIEDLDLKLRPGMVtLTWTSMnIESY 780  Tetrahymena thermophila SB210
EGD73488  738 IKTYSIAMNQL---DDrphltPLVARWYNRVHDQIAYGMD-LTWESP-LEAY 784 
EHY54023  812 VAGYFSAVRAI---QEtpsvaPLMASYEKEVQNLFATGVR-LRWESF-INSY 858 
ERT02584  854 VRTFAQTLRTI---NEmpevsMLLNGHRNDVYALIAKGVP-LRWESF-VNSY 900 
EOR01533  763 VRTYSLTVERI---TAnpgiePLIAEYRIEAQNIITKGMP-LRWEFF-VNTY 809 
Q5KFR9    809 VKTYTQTLELI---ESnpdvaILLASYRSHALQMIERGIK-MQWDHL-VNAY 855  Cryptococcus neoformans
KDE03481  838 VRTYSQTIAKL---QAnpgiaALVAEFRTNAQQQITKGMN-VRWEHV-VNSF 884 
EGU12573  815 VRTYSQTVAKL---EAnpdiaSLVATSHKKAQEQIAKGMS-YRWDHF-VNTF 861 
EPB90529  800 VRTFSQTVHKV---NRnpeisTLVAESRHEVHNMITKGIN-LRWDYF-VNTY 846 
EGF78727  730 VRTWDKTLNLL---SQnksicWLVATYHKSVQTLISKGIQ-LRWDYF-INTY 776 
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