Conserved Protein Domain Family
Ceramidase

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pfam05875: Ceramidase 
Ceramidase
This family consists of several ceramidases. Ceramidases are enzymes involved in regulating cellular levels of ceramides, sphingoid bases, and their phosphates, EC:3.5.1.23. This family belongs to the CREST superfamily, which are distantly related to the GPCRs.
Statistics
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PSSM-Id: 461766
Aligned: 151 rows
Threshold Bit Score: 153.871
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006675514  19 GAPSSSVDWCEMNYEVTTFIAEY-FNTISSFAMAVVGMLGVVLHPWAEM----RFHMAFQTTVAVGLGSVAFHCTLGKFS 93 
XP_003978122   6 SYESSEIDWCEDNYKHSEQVVES-FNTMSSFIFFIIAPIMLYLLHPYAKernlAIHLVWIMMIFVGLFSAYFHMTLSFVG 84 
XP_004068052  15 AYESSDIDWCEDNYKYSEHVVEY-FNTMSSFFFFIISPVMLYLLHPYAKernlAIHLVWILMIFVGLFSAYFHMTLSFVG 93 
XP_016083597   6 AYQSSEIDWCESNFPHSEVGGPSsYNTGDNATFFIFGPLMMYLLHPYAQkrslYVHCVWMLFMVVGVFSVYFHMTLSFLG 85 
EHB15102       6 AYQSSEVDWCESNFQHSALVAEF-YNTVSNVTFLIIGPLMGSLMHSYIQkrtrYIYCTLAFFVFTGLFSMYFHMTLSFLG 84 
XP_010805226   6 AYQSSEVDWCEPNFQYSQLVAEF-YNTFSNVTFFIFGPLMTFLMRPYIQqrsrYLYVLFVLFTVTGLFSMYFHMTLSFLG 84 
XP_004771627   6 AYQSSEVDWCESNFQHSELVAEF-YNTFSNVTFLIFGPLMMFLMHPYAQkrsrYVYITCVLFMVVGLFSMYFHMTLSFLG 84 
Q8R4X1        15 AYQSSEVDWCESNFQHSELVAEF-YNTFSNVFFLIFGPLMMFLMHPYAQkrtrCFYGVSVLFMLIGLFSMYFHMTLSFLG 93  house mouse
XP_008251096   6 AYQSSEVDWCEVNFQHSELVAEF-YNTFSNVSFLILGPLMTFLMHPYIQkrscGSYSTLFLFTVTGLFSMYFHMTLSFLG 84  rabbit
XP_003461147   6 GYQSSEVDWCESNFLHSPVVAEF-YNTFSNVTFLIFGPLMAFLMRSYVHkrsrYIYSVLMLFVLTGLFSMYFHATLSFLG 84  domestic guinea...
XP_006675514  94 QALDEVPMLYSALAFTYIGIceryspsaRVRRFLAIGLtf--------hAIFTTLLVTMSEGfwQFFLFHVSFGTAQLFA 165
XP_003978122  85 QMLDELSILWVLAAGYALWF--------P-RRLFPPFIkdrst-fstlvLVVTVVTTASSFV--KPTANAYALNCFGLHL 152
XP_004068052  94 QMLDELSIMWVLAVGYSMWF--------P-RKLFPSFIkdrtt-fsklvFTITVITSVSSFV--KPTVNAYVLNCFGLHL 161
XP_016083597  86 QLLDEIAILWLLAAGYSIWL--------P-RSYFPAFLkedrsrftrvvLITTVVSTFLSFI--RPTVNAYVLNGIALHI 154
EHB15102      85 QLLDEVSILWRVTRPPSVSV--------PGGCGAGSMgrsqf---tcmiLSGTVLVTFLSLV--RPTVNAYALNSIAIHI 151
XP_010805226  85 QMLDEIAILWLLASGYSIWL--------P-RCYFPAFLgqnrsryssliIIISLVSTFLSFL--RPTINAYALNAIGLHI 153
XP_004771627  85 QLLDEIAILWLLASGYSIWM--------P-RCYFPTFLgenrpqficlvVITTVVSTFLSFL--RPVINAYALNSIAVHI 153
Q8R4X1        94 QLLDEISILWLLASGYSVWL--------P-RCYFPKFVkgnrfyfsclvTITTIISTFLTFV--KPTVNAYALNSIAIHI 162 house mouse
XP_008251096  85 QLLDEIAILWLLASGYSIWM--------P-RCYFPAFLgg-------nrWGRLAVCHLLSFL--RTTVNDYALNSIAXHI 146 rabbit
XP_003461147  85 QLLDEVAILWMLSSCYSIWM--------P-RCYFPSFLrgsrfqftrmmLWGTTIVTFLSVV--RPILNAYALNSIAIHV 153 domestic guinea...
XP_006675514 166 IVQVICIY-RDReiphqfksgiiqrseitesskhrkhthdrkislenailsetkqllnthhdcadsisdhsvydnqracA 244
XP_003978122 153 LYVLAVEM-KHC-------------------------------------------------------------------T 164
XP_004068052 162 LYTLAVEM-RYC-------------------------------------------------------------------T 173
XP_016083597 155 LYIVALEY-RKT-------------------------------------------------------------------S 166
EHB15102     152 VYIVRLEY-KKT-------------------------------------------------------------------C 163
XP_010805226 154 IYIVVQEY-KKT-------------------------------------------------------------------K 165
XP_004771627 154 LYIVFQEY-KKT-------------------------------------------------------------------S 165
Q8R4X1       163 LYIVRTEY-KKI-------------------------------------------------------------------R 174 house mouse
XP_008251096 147 LYIVYQKYkK-T-------------------------------------------------------------------S 158 rabbit
XP_003461147 154 LYIVCSEYrKTT-------------------------------------------------------------------N 166 domestic guinea...
XP_006675514 245 NDPVALTFQRGILSYGVATFCWLTDMLFCE-LVNPhykgailpfnPQLHAWWHIFVSIGLYHLALLTLAARVDSKYGAGr 323
XP_003978122 165 DEKALRLAKFSVVLWVLAISCWISDRFGCSfWRKLn--------fCYLHGFWHILIAIAVAYGSTLIAYLDANYEIPYSl 236
XP_004068052 174 DQKVLRLAKLSVALWVLAITCWISDRFSCSfWQQLn--------fCYLHGIWHILIVMAVAHATTLIAYLDANNEIPYSl 245
XP_016083597 167 SAELKRLALVSVAWWFLAVVSWLSDRLLCAfWQRIs--------fFYLHSIWHVLISITFPHSVALMACVDAHYEMPQFv 238
EHB15102     164 NKQLRHMIEISVLLWASALISWISDLFFCSfWQRIr--------fFYLHSIWHVLISITFPYGMVTLALMDATYEMPGQt 235
XP_010805226 166 NKELQHLIEVSTVIWALAFTSWISDRLLCSfWQWIn--------fSYLHSIWHVLISFTFPYGMVILALVDSEYEMPNKt 237
XP_004771627 166 NKELRHIMEVSVVLWAFALTSWISDRLLCSfWQQIn--------fFYLHSIWHVLISITFPYGMVTMALVDARYEMPGQt 237
Q8R4X1       175 DDDLRHLIAVSVVLWAAALTSWISDRVLCSfWQRIh--------fYYLHSIWHVLISITFPYGIVTMALVDAKYEMPDKt 246 house mouse
XP_008251096 159 NKELRHLIEVSVVLWAIALTSWISDRFLCNfWQWIk--------fFYLHSIWHVVISITFPYGMVTMALVDASYEMPGQt 230 rabbit
XP_003461147 167 -RQLRHIIHVSTILWASAVISWVSDRLFCSfWQRIh--------fFYLHSIWHVIISITFPYGFVTMALVDATYEMPGEt 237 domestic guinea...
XP_006675514 324 avLRFW---Fn--iIPYIK 337
XP_003978122 237 pgLQYWpcdKwavgLPHIV 255
XP_004068052 246 pgLQYWpsdKwtigLPHIV 264
XP_016083597 239 seIHYWpknSwpvgLPYVV 257
EHB15102     236 lkVRYWprdSwpvgLPYIE 254
XP_010805226 238 lkVRYWprdTwpmgLPYVE 256
XP_004771627 238 lkVRYWprdTwpvgLPYVE 256
Q8R4X1       247 lkVHYWprdSwvigLPYVE 265 house mouse
XP_008251096 231 lkVRYWprdTwpvglpyve 249 rabbit
XP_003461147 238 lkVRYWprdSwpvgLPYIE 256 domestic guinea pig
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