Conserved Protein Domain Family
Caudal_act

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pfam04731: Caudal_act 
Caudal like protein activation region
This family consists of the amino termini of proteins belonging to the caudal-related homeobox protein family. This region is thought to mediate transcription activation. The level of activation caused by mouse Cdx2 is affected by phosphorylation at serine 60 via the mitogen-activated protein kinase pathway. Caudal family proteins are involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium, and are important in differentiation and maintenance of the intestinal epithelial lining. Caudal proteins always have a homeobox DNA binding domain (pfam00046).
Statistics
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PSSM-Id: 461413
Aligned: 24 rows
Threshold Bit Score: 70.9343
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_001100412  13 MY-PGTLRNPgGGStagvgts--------ggsgspLPASNFTAAPVYPHYMGYPHMSNMDPHGP-SLGAWSSPYSPPRED 82 
XP_005995007  13 MY-QGSARRS-SNN---------------------LPTQNFVSTPQYSDYGGYPHTHSVDNHAQ-SSAAWGSPYGPLREE 68 
XP_015207056  13 MYhQGPVRRS-SIN---------------------LPAQNFVSTPQYSDYTGYHHVPSMESNPApSSGPWGPAYGAPRED 70 
EOB09092      13 MY-PGPARCS-NNN---------------------LPVQNFASAPPYSDYMGYHHVPALDNHGQ-PAGTWGSHYGPQRED 68 
XP_005046021  13 MY-PGSARAN-SNN---------------------LPVQNFVSAPAYPDYMGYHPVPALDSHGQ-PAPAWGSHYGAQRED 68 
XP_003774801   1 MH-PGSQRAT-NLGsggigtgmgsgggslgggsghLPGQAFSSTPAYSHSLSYSPMANLDSHGP-WLGSWGSTYAPPKED 77 
XP_549080     55 MY-LGTLRSTaRSStagtagt--------gssgslLPASNFTAVPAYAHDMGYPHIPSVDPHGP-SLGVWGSPYSPSRED 124
XP_004064450  13 MY-PGTLRSP-GGDgtagtgg-------tggggspMPASNFAAAPAFSHYMGYPHMPSMDPHWP-SLGVWGSPYSPPRED 82 
XP_003360417  13 MY-SGTLRSPaGGGtaeaggt--------gscgspLQASNFATAPAYAHYMGYPHMPATDLHGP-SLGAWGSPYSPPRED 82 
XP_003412767  13 MY-PGTLRSPrGDGsadgdgt--------ggsgspLPAPNFGAVPAYVHYTGYPHMSNMDLQGP-SLEAWGSPFSLPRED 82 
NP_001100412  83 WSTY-PGPSSTMgtvp-------mndMTSSSPAFG-SPDYSTLGPtggaGGAsnGGsLPDAASESLvsidsgtsgGATSP 153
XP_005995007  69 WNAYgPGPSNTshtp--------innSSSGQISYN-SSDYNSMPP----SGS--GV-LPS-DTLTM---------EKYSP 122
XP_015207056  71 WCAYgLGPPNSLpap--------mngSSPGQVSYCpPPDYSSMHP----PAS--GVqLPPPENVAA---------AMHSP 127
EOB09092      69 WNAYgPGPSSTVaaaq-------ingSSPGQVSYS-SADYSSLHP----AGS--GG-LPPVDTINA---------QQISP 124
XP_005046021  69 WSAYgPGPSSALpaah-------ingSSPGQGSYS-SAEYSSLHP----AAA--AApLPPADTSHG---------QQISP 125
XP_003774801  78 WAPYgEGPSSSVvesspvqtlaqvlaLAPTPAPYG-ATDYSNLVR----PESs-GVvPPENM-EFT---------EPTSN 141
XP_549080    125 WNVY-PGPSSTVgtvp-------mndMISNPSAFG-SQEYSNLGPa---GGGstSGsLPAPSSRLLfpid-aeaaDASSP 191
XP_004064450  83 WSVY-PGPSSTMgtvp-------vndVTSSPAAFC-STDYSNLGPa---GGGtsGSrLPGPTGGSLvptd-agaaNASSP 149
XP_003360417  83 WNVY-PGPSSTMgtvp-------mndMTSSPAAFG-SPEYSNPAPa---GGGnsCSgLTGPAGGSLfpvd-actaDASSP 149
XP_003412767  83 WNVY-SGPSNTIgsvp-------tndLTPSPAAFG-LPEYCNLGPa---GGGnsGVsLPAPADRTLvpid-agtaDTSSP 149
NP_001100412 154 SRSRHSPYAWMRKTVQVTGKT 174
XP_005995007 123 SSQKRSPYEWMRKTVQSSSTG 143
XP_015207056 128 ERERRNSYEWMRKTVQSSSTG 148
EOB09092     125 NSQRHSSYEWMRKTVQSTSTG 145
XP_005046021 126 NSQRHSSYEWMRKTVQTNTAG 146
XP_003774801 142 PPNIGGPYAWMSKTLHVSGKT 162
XP_549080    192 NRSRHSPSAWMRKTLQVTGKT 212
XP_004064450 150 SRSRHSPYAWMRKTVQVTGKT 170
XP_003360417 150 SRSRHSPYAWMRKTVQVTGKT 170
XP_003412767 150 RRNRHSPYAWMRKTVQVTGKT 170
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