Conserved Protein Domain Family
Rab_eff_C

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pfam04698: Rab_eff_C 
Rab effector MyRIP/melanophilin C-terminus
This domain is found at the C-terminus of the Rab effector proteins MyRIP and melanophilin.
Statistics
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PSSM-Id: 461398
Aligned: 7 rows
Threshold Bit Score: 1141.91
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002759799 152 C-FDILG-GSLFESNLENEGSISGSDSTFYRQSEGHSVMDTLAVALRVAEEAIEEAISKAEA-YGDSLDKQNEASYLRDH 228
XP_007505105 152 C-FDIIE-ASFLEPSLENEGSISGSDSTFYRQTEGHSMMDTLAVALRVAEEAVEEAISKAEA-SGDSLDKQNEACYLREH 228
XP_002938352 152 C-ADIVE-GNFIDESIENEGSLCGSDSTFYRQTEGHSMMDTLSVALRVAEEAVEEAIAKADS-YRDSLDKQNEACYLREH 228
XP_008113754 151 AySDLLEvGSICEGTIENDGSICGSDSTFYRQSEGHSMMDTLAVALRVAEEAIEEAISKAEMfSNNSLDKQNEARYLRDH 230
XP_003477045 152 GfDVLA--GGFLESHLENEGSASGSDSTFYRQSEGHSMIDTLAVALRVAEEAIEEAISKAEA-HADSLDKQNEATYLRDH 228
Q7TNY7       152 C-FDILG-GGLYEPNLENEGSISGSDSTFYRQSEGHSMMDTLAVALQVAEEAIEEAISKAES-QRDSLDKQNEASYLRDH 228 Norway rat
XP_031446239 152 C-PDVIE-GGCFEGSFENDGSICGSDSTFYRQTEGHSMMDTLAVALRVAEEAVEEAISKAET-YSDSLDKQNEACYLQEH 228 Ring-necked phe...
XP_002759799 229 KEELTEELATTILQKIIRKQKSKsEQQv-EEEPGWPHP--QSCSTKVA---DEGTSAPPGGHRAPTALW-RSQSAFSVTG 301
XP_007505105 229 KEELIEELATTIVQKIIRKQKSK-EQT--EKESDWTQP--SSNARKVT---GQRMPAFPGEQQASCSLLqRSQSAFSLTG 300
XP_002938352 229 KEELIEELATTIVQKIIKRKKSKsEQA--EAIYEWQQS--RGSAITSPatsDRSMLNLQDSNRGSDALW-RSHSAFSLMS 303
XP_008113754 231 KEELIEELATTIVQKIIRKQKNKtEQV--EAGTDWPQSrsSSGPTSVTl-sDQSMLTFPGSRRGSYTLW-RSQSAFSLTT 306
XP_003477045 229 REELTEELAATILQKIIRKQKSRsEQHr-EEEPEWPLL--RDCSAKEE---DEGHKAALGDPRVPTALW-RSQSAFVFPG 301
Q7TNY7       229 RQELAEELAGTILQRIIRKQKDKaDLHaeEEEPECTRP--QSSGVKAR---GEGTAAPPGRHKARAALW-RSQSAFSFTT 302 Norway rat
XP_031446239 229 KEDLIEELATTIVQKIIKKQKGKtEQA--EADFEWPPSr-SSGLASVAv-sDQSMLTFPGSRRGSYTLW-RSQSAFSLAS 303 Ring-necked phe...
XP_002759799 302 EDA------LKTPPvEAASRQPGDQGQHPRAE--SALPSWKSVDRLDETNLA-PVLQSSDGNWVALKDGA-PPPTRLLAK 371
XP_007505105 301 QEApskeskVSAPL-ETLWAEQRVQEQKPKEQehAALPSWKSMDRLDETNLEdPVLQSADGNWVALKNKL-FPHHRLLAK 378
XP_002938352 304 EDTpstnvdMKSARpEVLCQHPRNCSKRAKERrpSTLPSWKSVDSLYDSSPS-PVLHSSDGNWVALQSIT-LPPPRMLAQ 381
XP_008113754 307 EEAssrdvdLASSVsESLWKQPKAPVRSQKDHrlSALPSWKSVDRLNEPTFP-PVLESTDGNWVALQNVT-LPHPRMLAK 384
XP_003477045 302 GDP------GKTPSlEAVVR------QRPGQP--CALPGWRSVDGLDGTGAA-PVLQSPDGNWVALKDGA-APPAHLLAT 365
Q7TNY7       303 EDT------LKTSSaEAAPRQPKDRAQRLLEE--SALPSWRSMDGLDGKNLV-PLLQSPDGNWMTLKDSSrQPPTRLLAK 373 Norway rat
XP_031446239 304 EDTpskgldPASSVtEALWRQQKGQFKKQKERklSALPSWKSVDRLNETNPP-PVLQSTDGNWVALQNIS-LPRPRMLAK 381 Ring-necked phe...
XP_002759799 372 PKSGTFQALEVASSVASAYDEMGSDSEEDFDWSEALSKLCPRPRGLPR-----NPQPQPTQAQSSDQGPMAASPISAISP 446
XP_007505105 379 SKSQAFQALEKESSVVSAYDEMGSDSEDDFDWNMTLNKLHQRPQSLSEnsystDSPHHTEWAYGHDQCPRGTSPSSGLYT 458
XP_002938352 382 PKSQVFKALEDESRVVSAYDEMGSESDEEVDWSLALNAYRRRARDLSDdscyaDSQYNPEWACSNDYYQPVTSPSSGLYT 461
XP_008113754 385 PKSQVFRVLENESNVVSAYDEMGSESEDDYDWNVALNKLRRRPKHLSNs---aDSPCNTEWAYGNELHQPMTSPSSGLFA 461
XP_003477045 366 RKSATLQALEVTSRASSAYEGLGSDSEEDFDWSMALGELCLQPQ-------------------SSNHGPLAASPSPAASP 426
Q7TNY7       374 PKSRTFQALEVASSVASAYDELGSDSEEDFDYSEALSKLRPPSQGRLK-----QPQPQPAQAQSSGQGPLATSPS----- 443 Norway rat
XP_031446239 382 PKSQVFEALENESSVVSAYDEMGSDSEDDYDWNVALNKLRRRPRQLPDdfyctNSQYDSEWVYGNDQYQAVTSPSSGLYT 461 Ring-necked phe...
XP_002759799 447 NPEAMCSDSETSSAGSSREVGHQARLSWLQRKAPRNPA-AEKMRLQGELDVNFNPQAASGETSDSSEPEEAPHTTDRRAR 525
XP_007505105 459 NTEAMCSDSETSSVSSSREVQGPAKRPWLQRKPPSNHS-LEKAHLQGGLDVNFNPQATDTQDSDSSEAEATHHTADKRSR 537
XP_002938352 462 NTETVYSDSETSSLNSLKETRQSSKSLWPNRKVPFNQ--IQKDHGYGKMDINFNPQSNSMEYSDSSEAEKTHFDVEKKSR 539
XP_008113754 462 N-ETMCSDSETSSINSSREARGTSLPPWIQRRTCNNKSrEDKAQLHGELDVNFNPQTTSLDYSDSSESEEAYHDLEKRSK 540
XP_003477045 427 NPEAMGSDSES-SAGCSQDSRHGARPSWPPRKAPWNPA-AERVHLQGELDVNFNLQAAGGNTSDSSEPEEAPHEMDQQAR 504
Q7TNY7       444 NPEAMCSDSETSSTSSSREAGCRAKLLWLQRKAPKNPS-AEKTHLQGELDVNFNPQAAGGETSDSSDPEETLHTADRRAR 522 Norway rat
XP_031446239 462 NTETLFSDSETSSVNSSQEAKGPSKLLWLQSRTQSDVPrMEKKHFHGELDVNFNPQATSLEYSDSSETEEVQYDLEKRSR 541 Ring-necked phe...
XP_002759799 526 RWRRARLGSEEPSKEPSSPSAQHRDLDTRQMLGDLSETDISNEAQDPRTPTDTTEEKRRNRLYELAMKMSEKETSSGEDQ 605
XP_007505105 538 RWRRNKLASEELGEEQPPTQSHEKDSDSNQVFDDLSETDISSEDHHHKSRTNDTEDKLKSRLFELAAKMSEKETSSGEEQ 617
XP_002938352 540 RWKRNKTEIEEQGD---FMKGQKRSLSTNTAFSDVSETDTGNRGPHHRTMTDNLEQKLKTKLCELTAKISDKETSSGEEQ 616
XP_008113754 541 RWKKSKAISEDLCRGKNRTKTHKKTLSTSQASEDLSETDISSEDQQHQTMADPLEEKLKSRLYELAAKMSDSRETSSEEQ 620
XP_003477045 505 RWHRACLDPKEQC----TPDSHAVHPHVHQVPSNLSETDLSNEAADSRTSIDTAEEKQRSRLYELAMKLSEKGTSSGEDP 580
Q7TNY7       523 RWRRARVGPEESNRGLPSPSAYPPALHTAQVSDNVSETDISNEAQNSRSSTDSAEEKLRNRLYELAMKMSEKETSSGEDQ 602 Norway rat
XP_031446239 542 RWKKNKTISEELCEGKNHTKANVKNLS--QDLDDLSETDRSSEDQHHNIKPELMEEELKSRLFQLAAKMSDKETSSGEEQ 619 Ring-necked phe...
XP_002759799 606 ESEPKTESENQKESLSSEDNSQSVQEELKKKFSAVSLCNISTEVLKVINATEELIAESTGPWESPQVPPDREKGTFPRGT 685
XP_007505105 618 ESEPRTESDHQKGSLSSEDNGQCIQEELKKKYSAVSLCNISTEVLKVINATEELIAESTGPWDFPADPPEKEKGPFPLGT 697
XP_002938352 617 DPEFRVENRNPE--MLSEESGMCVQEELKKKYSAVSLCNISTEVLKVINATEEMIAGSSGPWESPANTHDR--GSFPIGA 692
XP_008113754 621 VSEPRTESENQKSCISSEDSGKRVQDELKKKYSAVSLCNISTEVLKVINATEELIAESTGPCDFPADTHDKGKGEFPLGT 700
XP_003477045 581 ESEPRTEPEDPKEGLSSEESTRSVQHELRKKYSAVSLCNISTEVLKVITATEELIAESTGPWELPPVAAGTEERTFPLGT 660
Q7TNY7       603 ESESKTEPKNQKGSLSSEENNQGVQEELKKKCSAVSLCNISTEVLKVINATEELIAESAGPWEIPPVSTDRDNGMFPLGT 682 Norway rat
XP_031446239 620 ESEPRTDPENQKESLSSEENGKSIQEELKKKYSAVSLCNISTEVLKVINATEELIAESTNPCDFPDDVQDKGRETFPLGT 699 Ring-necked phe...
XP_002759799 686 DQVRLDEQLTSLEENVYLAAGTVYGLESQLTELEDAARSIHSGTEETHLADLEDQVATAAAQVHHAELQ----------- 754
XP_007505105 698 DHVRLDEQLTSLEENVYLTAGTVYGLEGQLNELEDAARRISSTTGELELAELEDQVATAAAQVHHAEQQmrnsgpergtd 777
XP_002938352 693 DPVRLDEQLTKLEENVYLTAGTVYGLEGQLSEIEDSARKISSVTTELELADLEDQVATAAAQVHHAERQ----------- 761
XP_008113754 701 DPIRLDEQLTTLEENVYLTAGSVYGLEGQLNELEEAAREINSITAESELADLEDQVATAAAQVHHAERQ----------- 769
XP_003477045 661 NQARLEEQLTSLEENVYLAAGTVYGLEGQLTELEDAARCIHSGTQDTELAELEDQVASAAAQVHHAELQ----------- 729
Q7TNY7       683 DQRSLDKQLTSLEENVYLAAGTVYGLEGQLSELEDAARCIHSSTGETELADLEDQVAAAAAQVHHAELQ----------- 751 Norway rat
XP_031446239 700 DPIRLDEQLTTLEENVYLTAGTVYGLEGQLTSLEDAARQISSVTAESELAELEDQVATAAAQVHHAELQ----------- 768 Ring-necked phe...
XP_002759799 755 -------ISDIESRISALTIAGLNIAPCVSLTRRRNQKQRTQVQTIDTSRQQRRKLPAPPVAAEKNETSSVTTIKTFNRN 827
XP_007505105 778 lpkatgvISDIESRIAALTLAGLNVAPCDRLTRKRNQKQMNQVQTIDTSRQQRRKLPAPPVKNEKMEAASLTSVKTFNRN 857
XP_002938352 762 -------ISDIESRISALTIAGLNVAPCVRLTRRRELISSSQVQTIDTSRQQRRKLPATPLQDEESEGSVVTAMRTFNHN 834
XP_008113754 770 -------ISDIESRISALTVAGLNVAPCIHLRRKREQQQTNQMHTIDTSRQQRRKLPAPPVKGENVNVSPVTPVKTFNRN 842
XP_003477045 730 -------ISDIESRISALTIAGLNIAPCVRFTRKQEQKRRSQVQTIDSSRQQRRKLPAPPVRAENTEACSVTTVKTFNRN 802
Q7TNY7       752 -------ISDIESRISALTIAGLNIAPCVRLTRRRDQKQRSQVQTIDTSRQQRRKLPAPPVKAEKIEASSVTPIKTFNRN 824 Norway rat
XP_031446239 769 -------ISDIESRISALTVAGLNVAPCVHLTRKRDQKQTNQMHTIDTSRQQRRKLPAPPIKGEKIDGSPITTVRTFNRN 841 Ring-necked phe...
XP_002759799 828 YILQGSSKNRTK-ERKITTKDLMEPALESAVMY 859
XP_007505105 858 FILQGSMTQRTK-ERKSTAKDLMEPTPGSAIMF 889
XP_002938352 835 FVLQGSLTQRTK-ERKNAAMDVMEPTKGSTIMY 866
XP_008113754 843 FILQGSLTQRTKmERKSTAKDLKEPTIGSAVMY 875
XP_003477045 803 FILQGPASR----PAESSPQDLTEPVLESAGMY 831
Q7TNY7       825 FLLQGSSTNRPT-ASTSNTKDLMEPVLESAVMY 856 Norway rat
XP_031446239 842 FMLQGSLTQRTK-ERKSTAKDLMEPAIGSAVMY 873 Ring-necked pheasant
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