1CF7,4YO2,1CF7


Conserved Protein Domain Family
E2F_TDP
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pfam02319: E2F_TDP 
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E2F/DP family winged-helix DNA-binding domain
This family contains the transcription factor E2F and its dimerization partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
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Statistics
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PSSM-Id: 460530
Aligned: 166 rows
Threshold Bit Score: 48.1963
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1CF7_A            8 HEKSLGLLTTKFVSLLqeakDGVLDLKLAADTLA-------------------VrQKRRIYDITNVLEGIGLIEKKSK-- 66 
A0BSR6          135 SQKGLRNLSVKVRDIVle-lKS-TSYKDVAQRLIqdlgsdgqiveldnpkdeqN-IKRRVYDALNVMIASKVLRKEGKrv 211 Paramecium t...
jgi:OSTLU_38105  74 EQKGLRHFSMRVCEKVe--eKKHTSYNEVANELVeelrvtaee--tnadfdekN-VRRRVYDALNVLMALEIIRKK-K-- 145
XP_018678602     56 KGWGLRRFSTIVCDKVk--eKGRTTYNEVADEIIyelsslekk-dlqfvfdekN-IRRRVYDAFNVLMAINVIAKD-K-- 128
XP_015688293     65 TGWGLREFSKIVSKKVe--aKGRTTYNEVADEIFaelksith---nglefdekN-IRRRVYDAFNVLIAIRVIAKD-K-- 135
EFJ49667         21 SAGGLRLFSLKVVEKIr--sRVRTTYNAVANELVsdqnmsg-----gnardgkS-IRRRCYDAINVLLACGLIMKDDK-- 90 
XP_005851360      1 -GKGLRHFSLKVCEKVe--sKGDTTYEEVANELIadlaaevaagtveqlhdekN-IRRRVYDALNVLEAIGMINKN-K-- 73 
EIJ87361          8 ERTGLKAFSAMILSIMq--kEKSIEYTKVADIIMsmteg---------tgddkN-VKRRVYDALNVMCAVNLIKKE---- 71 
XP_002996121     13 KKDGMKYITSSVYNIIk--nNDGVTYAYICENIQmts--------------kkT-LYRRIYDVLNVMKAVQIIDKKNK-- 73 
EOB15196         13 KKEGLKYIASAVYKLIk--eENGCTYSYICDNIPlpn--------------rrT-LHRRIYDVLNVMKAVNLIDSKNK-- 73 

1CF7_A           67 -NSIQW---KG 73 
A0BSR6          212 iSDVYCkhrMR 222 Paramecium tetraurelia
jgi:OSTLU_38105 146 -KEIFW---NG 152
XP_018678602    129 -KEIKW---VG 135
XP_015688293    136 -KEIKW---MG 142
EFJ49667         91 -KQIVW---RG 97 
XP_005851360     74 -KAIQW---KG 80 
EIJ87361         72 -KKMAYltdNQ 81 
XP_002996121     74 ----KY---FM 77 
EOB15196         74 ----KY---FL 77
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