2EP4


Conserved Protein Domain Family
RING-H2_RNF24-like
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cd16469: RING-H2_RNF24-like 
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RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins
This subfamily includes RNF24, RNF122, and similar proteins. RNF24 is an intrinsic membrane protein localized in the Golgi apparatus. It specifically interacts with the ankyrin-repeats domains (ARDs) of TRPC1, -3, -4, -5, -6, and -7, and affects TRPC intracellular trafficking without affecting their activity. RNF122 is a RING finger protein associated with HEK 293T cell viability. It is localized to the endoplasmic reticulum (ER) and the Golgi apparatus, and overexpressed in anaplastic thyroid cancer cells. RNF122 functions as an E3 ubiquitin ligase that can ubiquitinate itself and undergo degradation through its RING finger in a proteasome-dependent manner. Both RNF24 and RNF122 contain an N-terminal transmembrane domain and a C-terminal C3H2C3-type RING-H2 finger.
Links
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Statistics
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PSSM-Id: 438132
Aligned: 10 rows
Threshold Bit Score: 69.3395
Created: 2-May-2013
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H H C C CClick to see conserved feature residue pattern help
Evidence:
  • Structure:2EP4; Homo sapiens RNF24 binds two Zn2+ ions through its RING-H2 finger.
    - View structure with Cn3D
  • Comment:C3H2C3-type RING-H2 finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-H-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #               # #  #  #          #  #    
2EP4_A        16 ELCAVCLEDFKp-rDELGICPCKHAFHRKCLIKWLEVRkvCPLCNMPV 62  human
XP_002129362  80 ETCPVCLEDFKk-kEVLAICPCHHVFHKKCLCKWLELRptCPMCMSHI 126 Ciona intestinalis
Q9H9V4        91 QTCAVCLEDFKg-kDELGVLPCQHAFHRKCLVKWLEVRcvCPMCNKPI 137 human
XP_013415876  59 DVCPVCLDEFKl-kEKIALCLCRHAFHLKCLLQWLEQRnsCPMCNTQV 105 Lingula anatina
XP_013077189  61 DTCSVCLEEFKk-gEKIAVCTCRHGFHSKCLEQWLEHKnnCPLCKAPV 107 Biomphalaria glabrata
EDO49300      82 DMCTICLEDFIn-kEEVNMCKCGHAYHNKCIMKWLEVRnsCPICQRGL 128 starlet sea anemone
XP_003724489  54 DACAVCLEEFIl-gERVGQCPCKHNFHTVCVSRWLDSHetCPICQTRV 100 purple sea urchin
NP_001324239 490 RKCAICLEEYKekeELGEVKGCGHDYHGRCIKKWLSMKnsCPICKSPA 537 thale cress
NP_001168137 486 ARCVICLEDYKf-eDSVGKLKCNHKYHADCIKKWLQVKnaCPVCKASA 532 Zea mays
NP_001042083 454 GKCAICLEEYKd-nSLLGILKCNHDFHTDCVKKWLKEKnsCPICKSAA 500

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