Conserved Protein Domain Family
DUF5920
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pfam19334: DUF5920 (this model, PSSM-Id:437166 is obsolete and has been replaced by 466045)
Domain of unknown function (DUF5920)
This domain is found in the Telomerase protein component 1 (TEP1) and it contains an homology region to the telomerase associated protein from Tetrahymena p80. TEP1 is a component of the telomerase ribonucleoprotein complex and is thought to be responsible for catalysing the addition of new telomeres to chromosomes. TEP1 is also a component of the vault particle, a cytoplasmic ribonucleoprotein complex, in which it is required for vault RNA stability and its association with the vault particle. This domain is localized between the TROVE (pfam05731) and DUF4062 (pfam13271) domains.
Links
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Statistics
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PSSM-Id: 437166
Aligned: 10 rows
Threshold Bit Score: 395.298
Created: 28-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_023396430  665 NANSLCPKSNPQGPPLNYVLLLVGMMIARAEQAELLLCGKGTLKTAVLKAEEGILKTATELQAQVQELDAKDedEWPLNT 744  African savan...
P97499        696 NADRLCPKSHSQGPPLNYVLLLIGMMVARAEQVTVCLCGGGFVKTPVLTADEGILKTAIKLQAQVQELEGND--EWPLDT 773  house mouse
EHB04616      645 RADLLCPKSNTQGPPLNYVLLLIGMMMARAEQAEVLLCGRGTVKTAVLVAEDAILKTAITLQAQVQEMEEVD--ECPLTT 722  naked mole-rat
XP_012891162  486 GADRICPKSNTQGPQLNYVLLLLGMMMARAEQVKVLLCGRGTLKTAELKAEEGILKTAGKLQAQVQELEEND--EWPLFT 563  Ord's kangaro...
XP_018865686  687 NADRLCPKSNPQGPPLNYALLLIGMMITRAEQVDVVLCGGDTLKTAVLKAEEGILKTAIKLQAQVQEFDEND--GWSLNT 764  western lowla...
XP_023373349  617 CADRLCPKSNSEGPPLNYVLLLIGMMIARAEHADLLLCGRGTWKNMVLKAEEGILKTAIKLQAQVRELVEEH--EWPLHT 694  small-eared g...
1_pfamImport    1 NADKLCPKSNAQGPPLNYALLLIAMMIARAEQVDLVLCGRGTLKTAVLKAEEGILKTATELQAQVQGLEEKE--DSSLHT 78  
XP_019824006  726 SADRILPKSNPQGPPLNYVLLLIAMMMVRTEQVELLLCGGGIVKTAVIKAEEGILKTATELQAQVQKSDESC--EQSLTT 803  zebu cattle
ELK07093     1380 DADNCYPKSNPQGPPLNYVLLLIGMMIARAEHADLLLCRRGALKTAVIKAEEGILKTAIELQAQVQELNENH--EWSPPD 1457 black flying fox
XP_004781520  696 GTEELCRKSNLQGPPISYVLLLIGMMIARAEQVDLLFCGGGTMRTAVLKAEEGILKTASMLQAQAQDLDEEG--EWSLQT 773  domestic ferret

XP_023396430  745 FGKYLLSLAAQRVPVDRVIVFGQVTNQRLINVAKQLFWQHVNSKCLFVGVLLQMTGLTFTNVNPKDVTLSGCTDGILKFI 824  African savan...
P97499        774 FGKYLLSLAVQRTPIDRVILFGQRMDTELLKVAKQIIWQHVNSKCLFVGVLLQKTQYISPNLNPNDVTLSGCTDGILKFI 853  house mouse
EHB04616      723 FEKYLLSLAVQRVPVDRVVLFGEMLRSPIVTVAKHIIWKHVNPKCLFVDVRVRKP-YPYSEFHPNHVTLSGCTDGILKFI 801  naked mole-rat
XP_012891162  564 FGKYLLSLAVQRVPVDRVILFGQTMNDTMLNAAKQMIWQHVNSKCLFVGVVLRKVQYMSPNLNPRDVTLSGCTDGILKFI 643  Ord's kangaro...
XP_018865686  765 FGKYLLSLAGQRVPVDRVILLGQSMDDGMINVAKQLYWQRVNSKCLFVGILLRRVQYLSTDLNPNDVTLSGCTDAILKFI 844  western lowla...
XP_023373349  695 FGKYLLSLAVQRVPVDRVILFGETMDEQMINVAKELFWQHVNSKCLFVGVLLKRERYISSDSNPNDVTLSGCTDGILKFI 774  small-eared g...
1_pfamImport   79 LGKYLLSLTVQRVPVDRVILFGEMMNERSINVAKQLFWQHVNPKCLFVGVVLRHP----PVSHPNDVTLSGCTDGILKFI 154 
XP_019824006  804 LGKHLLSLATQRVPVDRVIVFGQTTNEKLINAAKQLFWQHVNPKCLFVGVLLRAS-YLCTDLNPNDVTLSGCTDGILKFI 882  zebu cattle
ELK07093     1458 FGKYLLTLAAQRVPVDRVIIFGQTMNEKLVNKAKQLFWQHVNSKCLFVGVLLRSTYYMFQDLNPNDVTLSGCTDGLLKFI 1537 black flying fox
XP_004781520  774 FGKYLLSLAAQRVPVDRVILFGNTMCNRLVNEAKQLFWQHVNSKCLFVSVPLQRTCNILPDSNPNSVTLSGYTDGILKFI 853  domestic ferret

XP_023396430  825 AEQGASRLLEHVGQMDRIFNIPPPPGKTGLLSLRPLEENIPSPLA 869  African savanna elephant
P97499        854 AEHGASRLLEHVGQLDKLFKIPPPPGKTQAPSLRPLEENIPGPLG 898  house mouse
EHB04616      802 AESGASRLLEHVDQMDRIFRIPPAPGKTQVLTLRPLEVDAPSPLA 846  naked mole-rat
XP_012891162  644 AEHGASHLLEHVDQMDRIFKIPPPPGKTQVLTLQPLEEDIPGLMA 688  Ord's kangaroo rat
XP_018865686  845 AEHGASHLLEHVGQMDKIFKIPPPPGKTGVQSLRPLEEDTPSPLA 889  western lowland gorilla
XP_023373349  775 AERGASRLLEHVGQMDKIFKIPPPPGKIGVLSLRPLEEDTPSPLA 819  small-eared galago
1_pfamImport  155 AERGASHLLEHVGQMDKIFKIPPPRGKTGAVCLRPLEEDVPSLLA 199 
XP_019824006  883 AERGASRLLEHVGQMDKIFKIPPPPGKTGVQSLRPLEENTPSPLA 927  zebu cattle
ELK07093     1538 AERGASRLLEHVGQMDKIFKIPPPPGKTGALSLRPLEENIPSPLA 1582 black flying fox
XP_004781520  854 AERGASRLLEHVGQMDKIFKIPPPPGKTGDLSLRPLEESTLRHLA 898  domestic ferret
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