Conserved Protein Domain Family
NCOA_u2
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pfam16665: NCOA_u2 (this model, PSSM-Id:435498 is obsolete and has been replaced by 465223)
Unstructured region on nuclear receptor coactivator protein
NCOA_u2 is a region of natively unstructured but highly conserved sequence found on higher eukaryote nuclear receptor coactivator proteins. It lies between a PAS domain, pfam14598 and a steroid receptor coactivator domain, pfam08832. The function is not known.
Links
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Statistics
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PSSM-Id: 435498
Aligned: 21 rows
Threshold Bit Score: 75.1503
Created: 27-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_016852042  467 HAM-NLSSSPMNSPGVTPPQ---FMSPRHRvspglvHRPRVPSNPFSPTMpTTHSPVGMmgg----cgVASAvGNRPYPG 538  green anole
XP_014341047  465 HPL-NLNSSPMGSPAVTPPH---FMSPRARgspglvGSPRISGNPFSPSMpGTHSPVAVpn-------sSISsASRPYSN 533  coelacanth
XP_009807463  460 YAL-KMNSPSQSSPGMNPGQpnsMLSPRHRvspgvaGSPRIPPSQFSPAG-SLHSPVGVc--------SSTG-NSHNYTN 528  red-throated ...
XP_007260174  466 YSL-KMNSPSQGSPG--------MLSPRHRaspgiaGSPRMPPPQFSPAN-ALHSPVPVcn------sSGNVgGAHGYTS 529  Mexican tetra
XP_015209118  469 YAL-KMNSPSQSSPGMTPGQqnsMLSPRHRvspgmaGSPRVPPTQFSPAG-SLHSPAGM---------NSSTgNSHSYSS 537  spotted gar
XP_011475689  488 FGLsGMNSPS-GSPRIGGPQqgfLMSPRNR------GSPKMGANQFSPG--GMHSPMGSigs----ggAGGG-GTSTFSS 553  Japanese medaka
XP_019205506  485 FGLsGMNSPS-GSPRMGVPQqglLMSPRNR------GSPKMGSNQFSPG--GLHSPMSGigs----ngGSGG-STTTFSS 550  Nile tilapia
2_pfamImport    1 FGLgGMNSPS-GSPRMSGPQqglLMSPRNR------GSPKMGANQFSPGA-GIHSPMSGigs----glGSGG-GGTTFSS 67  
XP_015220294  461 YGL-GMNSPSQGSPGMNVPQqnlMVSPRTR------GSPKMVPSQFSPG--GMHSPMGPgsa----ggAGGG-GNSNFSS 526  spotted gar
XP_022538482  528 YGL-GMTSPSHSSPGMNPSQqsiMGSPRIR------GSPKMGASPFSPG--GMHSPMGPvsmgsnsgaSGPA-GSSTFSS 597  Mexican tetra

XP_016852042  539 TPLNSMQGLREGPSPPVGYSTPSPVL--RQLSNQNspsrMSMPPMKTE--------PKDSKEMG 592  green anole
XP_014341047  534 NALNPVTGFGEGPSTPLGYSTPSPIQ--KQLSAQSspgpLAMQTAKPE--------PRDSKEMS 587  coelacanth
XP_009807463  529 SSLNALQALSEGHGVSLGSSLASPDL--KMGNLQNspvnMNPPQLSKMg-------SLDSKDCF 583  red-throated loon
XP_007260174  530 SSLNALQALSECHNISLGPALGSPDR--KLASPANpa-gVNPHLLHKLg-------GSESyaeh 583  Mexican tetra
XP_015209118  538 SSLNALHALSEAHGVTLGQSLASPDR--KLGNAQSspspANPHPLAKLg-------SSDFKESF 592  spotted gar
XP_011475689  554 SSLNALQAISEGVGSSLSSTLTSPPPahKPDSSPS----IHSSSSSSQpnqqgkpsQDGCKSPT 613  Japanese medaka
XP_019205506  551 SSLNALQAISEGVGSSLPSTLTSPSPahKPDSSPS----IHSSSSSSQ--------------PS 596  Nile tilapia
2_pfamImport   68 SSLNALQAISEGVGSSLPSTLTSPSPvlKPDSSPS----IHSSSSLSQltqtakggLDGSKSPA 127 
XP_015220294  527 SSLNALQAISEGVGNPMPSSLSSPAH--KPDSSPS----INSSQQQQQ------------QQQQ 572  spotted gar
XP_022538482  598 SSLNALQAISEGVGSSLQSALTSPPH--KSDGSPG----INSTQSSQS--------------NH 641  Mexican tetra
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