Conserved Protein Domain Family
HNOBA
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pfam07701: HNOBA (this model, PSSM-Id:429606 is obsolete and has been replaced by 462234)
Heme NO binding associated
The HNOBA domain is found associated with the HNOB domain and pfam00211 in soluble cyclases and signalling proteins. The HNOB domain is predicted to function as a heme-dependent sensor for gaseous ligands, and transduce diverse downstream signals, in both bacteria and animals.
Links
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Statistics
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PSSM-Id: 429606
Aligned: 61 rows
Threshold Bit Score: 180.08
Created: 27-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_001632464 230 KSMPLENFFNIFPFSFVISANMRISMAGHSLLSILgKELLGAKVTDAFTLRRPK-TEFTWENLQVWRAA-FELVSNLPSI 307  starlet sea an...
EDQ89423     187 LNLSPDTLDALFPWHLSFNRDFKVTSIGSNLAKRFaKSCVGDSLDAIARVVRPYtIKFEFDKKSEWDGSqMVFAVVRDDA 266  Monosiga brevi...
XP_001748626 205 VSMDSAAIDRLFPWHFAFDEELKIVSIGSQLRRHLnANPIGSKLADIMAIQRPLeAKYRYDDFQQRSGNpYQLALHRDAQ 284  Monosiga brevi...
EGD78923      61 aQLNAGMTNRLFPWHFAVDKDMKIVSLGKHLASRMkKDCIGMHAEKLFRIARPIdATWDFEDIKARCDKpFLFVTNPKRM 140  Salpingoeca ro...
EGD78919     203 aQLNAGMTNRLFPWHFAVDKDMKIVSLGKHLASRMkKDCIGMHAEKLFRIARPIdATWDFEDIKARCDKpFLFVTNPKRM 282  Salpingoeca ro...
XP_004997927 203 aqLDATMTNRLFPWHFAVDKDMRIISLGKHLASRMkKDCVGMHADKLFRIARPIdATWDFEDMRARCDKpFLFVTNPKRM 282  Salpingoeca ro...
EGD79412     203 idLGKSVTNDLFPWHFAFDRDMKIVSLGKHLAARFeEPQAGKPFKKVFRMLRPVdISSEFDELKDVDGVsCLFSVDAKLL 282  Salpingoeca ro...
EGD78581     203 vdlpASVTNDLFPWHVAFDRDMNIVSVGKHLAGRFkKQQLGAKAGSVFKIIRPShVRLKFDELMQAKDVpVLLSVDAKHL 282  Salpingoeca ro...
EGD74225     203 VAMPPSLTNDLFPWHVAFDRDMKIASLGKHLASRLkRKQIGAQAWQVFKVVRPSsMRLKFDDMLQVQGApILLSVDAKHL 282  Salpingoeca ro...
EGD74224     203 vdLPTEVTNELFPWHVAFDRDMKIASVGKHLAARFkKQQLGASASHVFKLVRPLgMSFSFDSLKTTQGApILLSVDAKHV 282  Salpingoeca ro...

XP_001632464 308 VETGAVRNIEKLQASYHQARTDFKRkKrldsnfngvqnkennfgyenripgrakelswikvdhrssgfgahglpiadake 387  starlet sea an...
EDQ89423     267 ARDEPVSMKCPVTGRTYELTGAAAErYrrv-------------------------------------------------- 296  Monosiga brevi...
XP_001748626 285 ADIQIASHYAATDDNSDACSVAASE-Lsnvgcpfsggrrrsde------------------------------------- 326  Monosiga brevi...
EGD78923     141 L-------------SAEEYAAMLSErQqrlaqedreqrhsnliqqfeqqssssqatsgrasartstqlpaaers------ 201  Salpingoeca ro...
EGD78919     283 L-------------SAEEYAAMLSErQqrlaqedreqrhsnliqqferqsidahaqekeaaddsarlnvp---------- 339  Salpingoeca ro...
XP_004997927 283 L-------------SAEEYSAMLTErHqqrqlhllkqtnrahleeaetakevqlpsmvdvskphvrlvvneaaeedrnep 349  Salpingoeca ro...
EGD79412     283 R---------------DDDAHGLAS-Gmqgmslmgnggdmasdmrsslvs------------------------------ 316  Salpingoeca ro...
EGD78581     283 V-QPDSSDDASVSDNADTSVSSLSQqMprlqvtedsrgnqrrstaamsacpfss-------------------------- 335  Salpingoeca ro...
EGD74225     283 T----------HEVTVDESVVTLTHhLpqlqvtdpsgargsesstgcpfsgt---------------------------- 324  Salpingoeca ro...
EGD74224     283 RKLDQQQPQQPHQHVHDASSANTSHaGsqrptlgpdqladrgsavggcpfssm--------------------------- 335  Salpingoeca ro...

XP_001632464 388 srttkrqetaknppeevrqakksekvgilsrvvdnlrcipmlidedgeevkdvaskngkrenksgfimsacdtvittedg 467  starlet sea an...
EDQ89423         --------------------------------------------------------------------------------      Monosiga brevi...
XP_001748626     --------------------------------------------------------------------------------      Monosiga brevi...
EGD78923         --------------------------------------------------------------------------------      Salpingoeca ro...
EGD78919         --------------------------------------------------------------------------------      Salpingoeca ro...
XP_004997927     --------------------------------------------------------------------------------      Salpingoeca ro...
EGD79412         --------------------------------------------------------------------------------      Salpingoeca ro...
EGD78581         --------------------------------------------------------------------------------      Salpingoeca ro...
EGD74225         --------------------------------------------------------------------------------      Salpingoeca ro...
EGD74224         --------------------------------------------------------------------------------      Salpingoeca ro...

XP_001632464 468 vmlrngsttfvrddcdgndmyidtinkdvvwvkqtphirpsnarkyykspgthpverterlcrhknsnartyiqnqeksd 547  starlet sea an...
EDQ89423         --------------------------------------------------------------------------------      Monosiga brevi...
XP_001748626     --------------------------------------------------------------------------------      Monosiga brevi...
EGD78923     202 -----------------------------------------------------------------------gagslrpsg 210  Salpingoeca ro...
EGD78919     340 ----------------------------------------------------------------------------rfsg 343  Salpingoeca ro...
XP_004997927 350 -----------------------------------------------------------------dadaqsqtdeerslv 364  Salpingoeca ro...
EGD79412         --------------------------------------------------------------------------------      Salpingoeca ro...
EGD78581         --------------------------------------------------------------------------------      Salpingoeca ro...
EGD74225         --------------------------------------------------------------------------------      Salpingoeca ro...
EGD74224         --------------------------------------------------------------------------------      Salpingoeca ro...

XP_001632464 548 kevcdslseeesdgvtvslpspskrrdsiysdspqdnvKKQPRIHLKGEMKYIKQNNKVLFVCSPVIGGFNEMMRCGVYM 627  starlet sea an...
EDQ89423     297 -----------------------------------gvaNLKGHLFLKGEVRYEQEMDVMVFVGTPHLSNLEELKTYDIDL 341  Monosiga brevi...
XP_001748626 327 ----------------------saissidrmqalrnmpQRI--IQLHGEFVALQEGQ-LFFAGAPLLRDVKQLDAQGITM 381  Monosiga brevi...
EGD78923     211 cpmtgmrhsqssattastsagtsarssmdllearsrhlKKASHIKLHGEVVFDEDKQVLLFVGNPFVQSMEELEAQGIDL 290  Salpingoeca ro...
EGD78919     344 fsgcpmtgrtpsghtsattsaahslrssmdahdiraraLRTNNIKLHGEVVFDEEQQVLLFVGNPLVQSTEELDTQGIDL 423  Salpingoeca ro...
XP_004997927 365 cpmsrrfdalsapslantsgstsrrssldaleqnsryiRKPTHIKLHGEIVYDEAKQVLLFVGNPLVQSLEELNKQGIDL 444  Salpingoeca ro...
EGD79412     317 ---------------cassfrgsnasssdmlmmanrlyAKADNIKLHGQLTYNSDHDVVVFFGTPALRSLEEMEAQRIEL 381  Salpingoeca ro...
EGD78581     336 ------------pgsainstasskrssmdmmlraarlaRKVDNIKLHGQVTFHEASGVLLFVGVPALYSLEEMETQGISL 403  Salpingoeca ro...
EGD74225     325 -------------sssfssntsskrssadmllraarltSKVDNIKLHGQITYHEESDLLLFVGVPALHSLEEMEAQGINL 391  Salpingoeca ro...
EGD74224     336 -------------ssastsaasskrtsvdmmmraarltNKVDNIKLHGQVTYHEGSDLLLFVGVPALHSLEEMEAQGINL 402  Salpingoeca ro...

XP_001632464 628 SDLGMHDRSQEMVLSGIQPLQQLEYARdQLLEKSRELEKNMKRVERERMRSNQLLYQMIPKQIADRL 694  starlet sea anemone
EDQ89423     342 VELPVHSNARDMVFAQQHSSATIGMAK-ELEVLTRELEVERENVNREKMRIHELLYSILPPTIADSL 407  Monosiga brevicollis MX1
XP_001748626 382 SDLPVHSHASEILYASMFQAMSAKRAN-KADKELLMLNNNRDEVRRQQEITANLLHSILPPRIADAL 447  Monosiga brevicollis MX1
EGD78923     291 TDLPVHSHGREVLYGSMCQAISASNSN-DVEAKLADLDRSMAEVHSKKEQIDGLLHSILPPVVADSL 356  Salpingoeca rosetta
EGD78919     424 ADMPIHCHGREVLYSAMCQAVSASNSN-EVEAKLADLDRSMAEVHSKKEQIDGLLHSILPPVVADSL 489  Salpingoeca rosetta
XP_004997927 445 ADMPIHCHGREVLYSAMCQAVSASNSN-QVEAKLADLDRSMIEVQEKKEQIDALLSSILPENVANAL 510  Salpingoeca rosetta
EGD79412     382 SEMPLHSHGREFLYGSMFQSASAKNSN-EVDRRMAELDQSMLEIQDKKKQIDGLLHSILPPVVASSL 447  Salpingoeca rosetta
EGD78581     404 SEMPLHSHGREVLYGSMFQSASAKNTN-EVDKRMAELDRSMLEVQEKKEQIDTLLHSILPPVVASAL 469  Salpingoeca rosetta
EGD74225     392 TELPLHSHGREFLYGAMYQSASAKNTN-EVDKRMAELDHSMLEVQQKKEQIDALLHSILPPVVASSL 457  Salpingoeca rosetta
EGD74224     403 TELPLHSHGREFLYGAMFQSASAKNTN-EVDKRMAELDHSMLEVQQKKEQIDALLHSILPPVVASSL 468  Salpingoeca rosetta
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