Conserved Protein Domain Family
KH_I_FXR2_rpt3
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cd22511: KH_I_FXR2_rpt3 
third type I K homology (KH) RNA-binding domain found in fragile X mental retardation syndrome-related protein 2 (FXR2) and similar proteins
FXR2, also known as FMR1L2, is an RNA-binding protein that plays a role in central nervous system function. It specifically regulates hippocampal neurogenesis by reducing the stability of Noggin mRNA. FXR2 contains three K-homology (KH) RNA-binding domains. The model corresponds to the third one.
Links
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Statistics
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PSSM-Id: 411939
Aligned: 5 rows
Threshold Bit Score: 155.919
Created: 17-Aug-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putativeGXXG motif
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  # ### #####  ##  ##     ####                                          
P51116       291 FSEDSVQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRVEGDndkkn----------------preeGMVPFIFVGTRENI 354 human
XP_014349797 416 FSEDSVQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRVEGDndkki----------------preeGMVPFIFVGTKENI 479 coelacanth
NP_956505    281 FKEDSFPVPRNLVGKVIGKNGKIIQEIVDKSGVVRVRIEGDndkklpreeggrqgagrdnivssqeGTVPFIFVGTKENI 360 zebrafish
GCF55672     291 FSEDSVQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRVEGDndkkn----------------preeGMVPFIFVGTRENI 354 Paroedura picta
XP_030042755 196 FSEDSVLVPRSLVGKVIGKNGKVIQEIVDKSGVVRVRVEGDndkkn----------------sreeGLVPFIFVGTKENI 259 Microcaecilia u...

Feature 1                      
P51116       355 SNAQALLEYHLSYL 368 human
XP_014349797 480 SNAQALLEYHLSYL 493 coelacanth
NP_956505    361 SNAQALLEYHVAYL 374 zebrafish
GCF55672     355 SNAQALLEYHLSYL 368 Paroedura picta
XP_030042755 260 SNAQALLEYHLAYL 273 Microcaecilia unicolor

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