5ELT,5EL3,5ELR,5EMO,5ELS,5ELT


Conserved Protein Domain Family
KH-I_KHDRBS3

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cd22470: KH-I_KHDRBS3 
type I K homology (KH) RNA-binding domain found in KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3) and similar proteins
KHDRBS3, also called RNA-binding protein T-Star, or Sam68-like mammalian protein 2, or SLM-2, or Sam68-like phosphotyrosine protein, is an RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. It binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. It also binds poly(A). KHDRBS3 may play a role as a negative regulator of cell growth.
Statistics
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PSSM-Id: 411898
Aligned: 11 rows
Threshold Bit Score: 195.268
Created: 19-Jul-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                               # ### #####  ##         ###    ###                       
5ELT_B        50 VVINKNMKLGQKVLIPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGSMRDKAKEEELRKSGEAKYFHLNDDL 129 human
5EL3_A         1 GAINKNXKLGQKVLIPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKXSILGKGSXRDKAKEEELRKSGEAKYFHLNDDL 80  Homo sapiens
5ELR_C         1 GAINKNMKLGQKVLIPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGSMRDKAKEEELRKSGEAKYFHLNDDL 80  human
5EMO_A        50 VVINKNMKLGQKVLIPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGSMRDKAKEEELRKSGEAKYFHLNDDL 129 human
5ELS_A         1 GAINKNMKLGQKVLIPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGSMRDKAKEEELRKSGEAKYFHLNDDL 80  Homo sapiens
O75525        48 VVINKNMKLGQKVLIPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGSMRDKAKEEELRKSGEAKYFHLNDDL 127 human
XP_014354465  18 VVINKNMKLAQKVLIPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGSMRDKAKEEELRKSGEAKYVHLNDDL 97  coelacanth
XP_007907438  89 VVSNKNMKLSQKVLIPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGSMRDKAKEEELRKGGETKYTHLNEDL 168 elephant shark
XP_018079471  47 VVINKNMKLAQKVLIPIKQFPKFNFVGKLLGPRGNSLKRLQEDTLTKMSILGKGSMRDKAKEEELRKSGEAKYYHLNDDL 126 African clawed ...
XP_001231272  48 VVINKNMKLGQKVLIPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGSMRDKTKEEELRKSGEAKYFHLNDDL 127 chicken
5ELT_A        50 VVINKNMKLGQKVLIPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGSMRDKAKEEELRKSGEAKYFHLNDDL 129 human
Feature 1                                         
5ELT_B       130 HVLIEVFAPPAEAYARMGHALEEIKKFLIPDYN 162 human
5EL3_A        81 HVLIEVFAPPAEAYARXGHALEEIKKFLIPDYN 113 Homo sapiens
5ELR_C        81 HVLIEVFAPPAEAYARMGHALEEIKKFLIPDYN 113 human
5EMO_A       130 HVLIEVFAPPAEAYARMGHALEEIKKFLIPDYN 162 human
5ELS_A        81 HVLIEVFAPPAEAYARMGHALEEIKKFLIPDYN 113 Homo sapiens
O75525       128 HVLIEVFAPPAEAYARMGHALEEIKKFLIPDYN 160 human
XP_014354465  98 HVLIEVFAPPSEAYARMGHALEEIKKFLIPDYN 130 coelacanth
XP_007907438 169 HVLIEVFAPPSEAYARMGHALEEVKKFLIPDYN 201 elephant shark
XP_018079471 127 HVLIEVFAPPAEAYARMGHALEEIKKFLIPDYN 159 African clawed frog
XP_001231272 128 HVLIEVFAPPAEAYARMGHALEEIKKFLIPDYN 160 chicken
5ELT_A       130 HVLIEVFAPPAEAYARMGHALEEIKKFLIPDYN 162 human

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