Conserved Protein Domain Family
C1_RASSF1
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cd20885: C1_RASSF1 
protein kinase C conserved region 1 (C1 domain) found in Ras association domain-containing protein 1 (RASSF1) and similar proteins
RASSF1 is a member of a family of RAS effectors, of which there are currently 8 members (RASSF1-8), all containing a Ras-association (RA) domain of the Ral-GDS/AF6 type. RASSF1 has eight transcripts (A-H) arising from alternative splicing and differential promoter usage. RASSF1A and 1C are the most extensively studied RASSF1 with both localized to microtubules and involved in regulation of growth and migration. RASSF1 is a potential tumor suppressor that is required for death receptor-dependent apoptosis. It contains a C1 domain, which is descibed in this model. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Links
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Statistics
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PSSM-Id: 410435
Aligned: 23 rows
Threshold Bit Score: 101.192
Created: 4-Oct-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Comment:Based on the structure evidence that Mus musculus RASSF5 binds two Zn2+ ions
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #            #  #               #      #    #  #       # 
Q9NS23        49 GRGHRFQPAGPatHTWCDLCGDFIWGVvr--kGLQCArlsaDCKFTCHYRCRALVcLDCC 106 human
KXJ23925      92 GRGHAFIPFQLrnPTWCDLCGEFIWGLyk--qCVRCK----NCKYTCHWRCREEIdLDCI 145 Exaiptasia pallida
OQR76788     123 GAGHEFQPANLdhPAWCDRCGDLIWCVgrlgqLVQCT----RCKFTCHAGCLQFItVDCQ 178 Tropilaelaps mercedesae
TRY73746     117 GEGHCFQVLGTfnPTWCDLCGDLIWGLyd-tgASKCI----HCSYTCHVKCQKKInLNCA 171 Tigriopus californicus
XP_022297766 107 VKGHDFVLQQLsnPTWCDECGDFIWGLyk--hCLRCK----YCHFTSHQKCAQFVrLPCK 160 eastern oyster
XP_024510142 158 GEGHEFHPIKLfnPTWCDKCGDFIWELll-kqTVQCK----YCQFTCHLKCSNLItLNCP 212 Strongyloides ratti
XP_023346102 113 GEGHDWVEQGCtnPTWCDLCGELIWGLyd-tgVWVCV----HCKYTAHVKCRERVkLDCS 167 Eurytemora affinis
XP_002606773   3 HLGHKFEVTSN--PTWCDLCGEFIWGFym-rqALRCT----YCRYTCHVRCRPSVsLECS 55  Florida lancelet
XP_012557286  72 FRGHRFELYHK--PTWCDICQELSWGLya--qSARCC----FCRFTCHLKCVNSVsLDCP 123 Hydra vulgaris
XP_028397524  94 GGGHVFVAHTDhyITWCDLCGETMWGFvk--rGVRCQ----RCKYTCHLRCKDEVlLECD 147 Dendronephthya gigantea

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