4B6D


Conserved Protein Domain Family
C1_MgcRacGAP
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cd20821: C1_MgcRacGAP 
protein kinase C conserved region 1 (C1 domain) found in male germ cell RacGap (MgcRacGAP) and similar proteins
MgcRacGAP, also called Rac GTPase-activating protein 1 (RACGAP1) or protein CYK4, plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling; and ii) after phosphorylation by aurora B, MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain an N-terminal C1 domain, and a C-terminal RhoGAP domain. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Links
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Statistics
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PSSM-Id: 410371
Aligned: 50 rows
Threshold Bit Score: 57.0305
Created: 4-Oct-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Structure:4B6D; Homo sapiens MgcRacGAP binds two Zn2+ ions.
    - View structure with Cn3D
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #                #  #            #  #    #  #          #    
4B6D_A          7 RLHDFVSKTVIk----pESCVPCGKRIKFgkLSLKCRDCRVVSHPECRDRCp---lPCIPTL 61   human
OQR70025      164 IPHKFGHSLAYn----nRKCDLCSRSVTMgtKVAVCQECEHSFHVDCSQNAp---pVCGLPR 218  Tropilaelaps mercedesae
KPM07423      701 FEHNFATSIARs----sNICVSCAKTIYFgqKVKKCQDCNATIHANCELFN-----NCGLSV 753  Sarcoptes scabiei
XP_009495678  569 IPHRFVEESSWf----nKRCFSCSKPIRDr-LLTKCTECSHFYHRSCAKKEa---pNCGLAS 622  Fonticula alba
KNC73799      126 IEHRFSDKSYVn-----GTCSLCEKKITEr-KAAKCDHCSYACHTKCVSMAk---pTCIQPP 178  Sphaeroforma arctica JP610
EEB19417     1321 IPHRFKSQTKIk----sGTCNVCNLQLSRngQCSICTQCKFVTHTKCAMIAp---kTCGLPQ 1375 human body louse
ORZ40287      430 NRHRFTVTRVDltdrteKHCRMCSQGFGFleKRVVCKDCRLTIHKDCYGTGhperyACECFN 491  Catenaria anguillulae PL171
CBY11246      335 AEHKFTTSRVLt----fETCRVCFKGIKFysKASKCDECKVICHPDCISKLd---fACKDTS 389  Oikopleura dioica
XP_004343922 1124 IPHRFQPHFNVk----sCKCTVCNKNVGLtrGSVKCSDCHAIFHAKCGESAp---aTCGISE 1178 Capsaspora owczarzaki ATCC 30864
XP_019856985  510 IPHRWVIKSGAfh--ksHSCSTCSGSIKHtqKYAKCAYCSFVVHQKCTSNTp---nSCGLPL 566  Amphimedon queenslandica

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