Conserved Protein Domain Family
TD_EMAP3

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cd21949: TD_EMAP3 
trimerization domain of echinoderm microtubule-associated protein-like 3
Echinoderm microtubule-associated protein-like 3 (EMAP-3), also called EML3, is a nuclear microtubule-binding protein required for the correct alignment of chromosomes in metaphase. It may modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. This model corresponds to a conserved region located at the N-terminus of EMAP-3, which shows high sequence similarity with the N-terminal trimerization domain of EMAP-2 and EMAP-4.
Statistics
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PSSM-Id: 409270
Aligned: 11 rows
Threshold Bit Score: 46.1685
Created: 4-Jun-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putative trimer
Feature 1:putative trimer interface [polypeptide binding site]
Evidence:
  • Comment:based on the structure of Homo sapiens EML2 trimer

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               ## ##  ## ##  ## ##  ## ##  ## ### ## #   
Q32P44          6 GPGDGPAREALQSLSQRLRVQEQEMELVKAALAEALRLLRLQVPPSSL 53   human
XP_016279066   37 GGGQAGAPDGLGALSQRLRVQEEEMELVKAALAEVLRRLRLREGSPLA 84   gray short-tailed opossum
XP_025001462    2 EPERESGDPGPPALERRLRAVEAEVAVLKAALGDALRRIGLWEGRLPH 49   chicken
XP_018113144    3 ETQPSGEFCTTAKWENRLQTQEEEIMLLKSTLCDVLRRICVLEHQIPP 50   African clawed frog
XP_018421207    4 DQSAGEYVCPTTEWEKRLQTQEEEVMLLKSVLRDVLQRLQNLEIHSHP 51   Nanorana parkeri
XP_030357457   15 PAGAAAPLGPSAPLEPRLRRLEEELALVRAALADALRRLGLYEQHLPR 62   Kakapo
XP_014354175   14 AGSSTEYPDRLSTVEQRLQTQEDEITLLKSALADALRRISFYDEQIPL 61   coelacanth
TFJ97589       17 ETISALRPDRLASLELRLQSQEEELTLVKSALADALRRLSLYDQQIPL 64   big-headed turtle
XP_030073489   11 GESSAEDPSRLATLEVRLQTQEDEITLLKSVLADVLRRIHFYDEQFPL 58   Microcaecilia unicolor
OWK50997       31 GPPPGEAEPPPGPLELRLRTVERELALVKAALGETLRSYGYRGRDSRS 78   Bengalese finch
RVE60167       13 ADGSTDYQDRTSGMEVRLQAQEDEITLLKSSLADALRRIHIHDQLLPL 60   javanese ricefish

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