Conserved Protein Domain Family
CH_EHBP1L1
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cd21255: CH_EHBP1L1 
calponin homology (CH) domain found in EH domain-binding protein 1-like protein 1 and similar proteins
EHBP1L1 may act as Rab effector protein and play a role in vesicle trafficking. It coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells. Members of this subfamily contain a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.
Links
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Statistics
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PSSM-Id: 409104
Aligned: 6 rows
Threshold Bit Score: 200.784
Created: 8-Oct-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative actin
Feature 1:putative actin binding site [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens filamin-A binds F-actin.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #   #                                                   # ##  ## #       ######
Q8N3D4       1038 SSSQSLLEWCQEVTTGYr--GVRITNFTTSWRNGLAFCAILHRFYPDKIDYasLDPLNIKQNNKQAFDGFAALGVSRLLE 1115 human
OCT84200     1893 SSIDSLLCWCQEVTASYr--GVRVNNFTTSWRNGLAFCAILHHFHPEIINYevLDPLNIKENNKKAFDGFASLGIPALLC 1970 African clawe...
XP_014345200 1244 SSCQSLLEWCQEVTKGYr--GVKVTNFTTSWRSGLAFCAILHHFHPDKVDYesLDPYDIKKNNKKAFEGFASLSIPRLLE 1321 coelacanth
PAA70210      316 AASQDLLAWAQSVTAGYrnrGVFVNNLTTSFRNGLAFCAIIHHHRPDLLEFagLKAHDLRENNRRAFEAAHQLGVPRVMD 395  Macrostomum l...
XP_025001280  228 GGRAALLSWCQEVTAGYr--GVRITNFSTSWRNGLAFCAILHHHRPCDVDYeaLDPLDIRGNNTRAFEAFSALGVPRLLD 305  chicken
XP_019747476  831 TCSQSLLRWCQEVTAGYp--GVKVSDFSASWSDGLAFCALVHRFHPQLMDFqqLNAHDAEINNKKAFAALESVGVPRLLE 908  tiger tail se...

Feature 1         ###       # ## ##  ##  #   
Q8N3D4       1116 PADMVLLsVPDKLIVMTYLCQIRAFCT 1142 human
OCT84200     1971 PTDMLLHpIPDKLIILTYLCQIRDHFI 1997 African clawed frog
XP_014345200 1322 PADMVLLaVPDKLIVMTYLCQIQAHFT 1348 coelacanth
PAA70210      396 PADMVMKtIPDQLLVMTFLHQLRAHFT 422  Macrostomum lignano
XP_025001280  306 AADMERPpAPDPLAVLTYVGLLRQHLE 332  chicken
XP_019747476  909 PSDMAARpLPDRLMVMTYASQLRGHFT 935  tiger tail seahorse

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