Conserved Protein Domain Family
CH_DIXDC1
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cd21213: CH_DIXDC1 
calponin homology (CH) domain found in Dixin and similar proteins
Dixin, also called coiled-coil protein DIX1, coiled-coil-DIX1, or DIX domain-containing protein 1, is a positive effector of the Wnt signaling pathway. It activates WNT3A signaling via DVL2 and regulates JNK activation by AXIN1 and DVL2. Members of this family contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.
Links
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Statistics
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PSSM-Id: 409062
Aligned: 17 rows
Threshold Bit Score: 161.311
Created: 7-Oct-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative actin
Feature 1:putative actin binding site [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens filamin-A binds F-actin.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #   #                                                        # ##  ## #        #
Q155Q3         22 QLQAYVAWVNAQLKKrpa-vkpVQDLRQDLRDGVILAYLIEIVAGEKLSGVql--sPGNQQEMKNNVEKVLQFVASKKIR 98   human
TRY77851      434 QLQAYIAWVNSQLRKrpd-lkpVQDLRTDLQTGEVLAQLIEIISGERIVGIey--nPESLQGMRENLERILQFMAHKRIR 510  Tigriopus cal...
XP_023932979   23 QLQAYIAWVNSQLKKkpn-triVEDLRRDMVDGVALVQLVEIVAGEKLAGVny--ePANPHDMKENIERVLQFMAARRIR 99   Lingula anatina
XP_002740353  101 QLQAYVAWANSQLKKrqg-crlVEDLRLDMQDGVLLVHLVEIVSGETLSGVdf--nPQSHVAMRANIERVLQFMASKKIR 177  Saccoglossus ...
XP_002609284   70 QLQAYVAWVNSQLKKrag-criVSDLRRDMQDGVAFAQLVEILSGETLPHVdy--sPKCLGTMKQNVEIVLQFMQTHRIR 146  Florida lancelet
RMX39786       55 REEQYVAWVNSQLKKrag-nrcVREIPRDTRDGVALVQLVEVLAGEALKFDd---sPTTYAAKKENVDQVLQFMASQRIK 130  Pocillopora d...
RDD44504        9 QIVTYTLWINSQLKKisg-qrqIYQFQDDLRDGVALAQLIAALSGEILPGIdn--nPETIEACQNNVDRVLQFMAAKRMQ 85   Trichoplax sp...
XP_004227212    6 QVQAYTAWVNSQLKKrg---knIVNLGEDLKDGVALVAVVEIVSGHTLGGIk----PTCENEKRENVLKVLQFMRNAGIK 78   vase tunicate
PAA81192        6 QVPSYTAWVNSQLKKrpgyppvKDLTDPSILNGTSLAVLIETVAGVKLEDIiw--yPIDDYDREQNILVVLDFMRSRRIR 83   Macrostomum l...
OQV23779       22 HYQAYLTWINCQLKKnpqairpIQDIRTELQDGTLVASLIEILGNHRLSGVdwqpaPQSLPVRISNYNAILRYLTLQRVA 101  Hypsibius duj...

Feature 1         ########     # ## ##  ##  #    
Q155Q3         99 MHQTSAKDIV-DGNLKSIMRLVLALAAHFKP 128  human
TRY77851      511 MHQISSKEIL-EGNLKAVMRLILALAAHYKP 540  Tigriopus californicus
XP_023932979  100 MHHTTAKDIV-EGNLKSIMRLILALAAHFKP 129  Lingula anatina
XP_002740353  178 MHHTAAKDIS-EGNLKAIMRLILALAAHYKP 207  Saccoglossus kowalevskii
XP_002609284  147 MHQTSAKDIV-EGNLKAVMRLILALAAYFKP 176  Florida lancelet
RMX39786      131 MRQISSKDIV-DGNLKATMRLVLALAAHFKP 160  Pocillopora damicornis
RDD44504       86 MHRTVAKDIV-DGNIKATMRLVLAIAAHYKP 115  Trichoplax sp. H2
XP_004227212   79 LHHVSVDEIT-SGNVKTIMQLILALAAHFKP 108  vase tunicate
PAA81192       84 MHRIEPRAVM-SGDVKAVMRLILALAAHYKP 113  Macrostomum lignano
OQV23779      102 LHPTINVADLaRGELKPLLRLIHALAGHFKP 132  Hypsibius dujardini

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