Conserved Protein Domain Family
zf-C2H2_12
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pfam18658: zf-C2H2_12 (this model, PSSM-Id:408440 is obsolete and has been replaced by 465831)
Zinc-finger C2H2-type
This is a zinc finger domain C2H2 type which can be found in SPIN1 docking protein (SPIN-DOC) and Epm2a-interacting protein 1 (Epm2aip1). SPIN-DOC is a Spindlin1 (SPIN1) regulator that directly binds and strongly disrupts its histone methylation reading ability, causing it to disassociate from chromatin. Epm2aip1 is a glycogen synthase (GS)-associated protein. In the absence of Epm2aip1, the sensitivity of the liver to insulin, in which GS is a principal actor, is impaired.
Links
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Statistics
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PSSM-Id: 408440
Aligned: 36 rows
Threshold Bit Score: 76.5396
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_010886244  423 PWRLRLDYLVAYGPQ-GRGTFCMVCSQVLPVAKVSNFRRHIQECHPETISLAREEREAMAKAWTK 486  northern pike
XP_003798630   70 QLSWEQEFLVGNSPGgSGRALCMVCGAEIRSPSADTARAHILEQHPHTLDLSPSEKSNILEAWGE 134  small-eared galago
KDR19425       16 SDEWEEKYFFIVQ---NTKLLCLICREVVAVFKEYNVKRHYETKHKDYLKFDKEVKQSKLKEFKS 77   Zootermopsis nevadensis
XP_013887771  890 EAAWRSRFLMDYNPL-NQLLVCMVCGELQYSHSMDGVRAHIDEVHPHTLTLEPRERQRILEAWDE 953  Austrofundulus limnaeus
CDQ77387     1467 DVVWRNRYLMDYDPL-NQLLVCMVCGELQYSHSLEGVRAHIDEAHPDTLSLESPEHLRILEAWDE 1530 rainbow trout
XP_009301278  993 QAQWRNVYLMDLDPV-IPLLVCMVCGEQQYSVSVEGVKAHIEEVHPHTLSLGELEHRGILNAWDK 1056 zebrafish
XP_017575444 1157 EARWRSTYLMDYDPI-NQLLVCMVCGEQQYCLSVEGVKAHIEEAHPGTLSLEERERQGILQAWDE 1220 red-bellied piranha
XP_030426649   66 GRAWQQEYLVGDCPG-RGGTVCMVCGTFLGTCGPSAAREHVLQHHAHSLGLSPEEKHNILEAWSQ 129  Goodes thornscrub tortoise
GCF46038       68 CASWKQEYLIGKSSG-HDRLVCMVCGGALSASGPAAAREHILQHHAHSLDFSLEEKQNILEAWSE 131  Paroedura picta
XP_012408345   77 LQSWEQEYLVGNSPGgSGRALCMVCGQELPTPSARSARRHILRQHPHTLGLSPGEKSNILEAWSE 141  Tasmanian devil
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