5A31


Conserved Protein Domain Family
APC1_C
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pfam18122: APC1_C (this model, PSSM-Id:407956 is obsolete and has been replaced by 465659)
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Anaphase-promoting complex sub unit 1 C-terminal domain
This is the C-terminal domain of chain A, also known as sub-unit 1, found in anaphase-promoting complex (APC/C) present in Homo sapiens. APC/C is an ubiquitin ligase that controls chromosome segregation and mitotic exit.
Links
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Statistics
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PSSM-Id: 407956
Aligned: 31 rows
Threshold Bit Score: 90.0987
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5A31_A             1272 SAFTSDPALLSFAEYFCK-PTVNmgq--------------kqeILDLFSSVLYECVTQETPEMLPAYIAMDQAI-RRLGR 1335 human
Q5KGI0             1700 RIHSGDASLVGLANHFTD-VSDDfg----------------sgIGTFLRTVIIECLALDKPHLIGVYLEIYLSL-RREAA 1761 Cryptoc...
KZV91613           1629 KSLKGNRHLAAYLDYLCR-RTSShet--------------dqdLHLFASAALLECLTLDKVHLLHAYLRLFKPIyEALPP 1693 Exidia ...
KLO17751           1717 TSHSNDISFIAFADRFCR-GDGVtea--------------ekvLSSFCHAALLDCIIQDKPQVLSSYLMLYRTR--IMNP 1779 Schizop...
KDQ11269           1891 TSFAHDSRVTAFADRFCR-NRAEtad--------------ekrLYAFCQQSLLECLAVDKPQTLQSYLTIHYTR-LLDPT 1954 Botryob...
CCA69952           1645 SAFTEDDRATTFAERLCT-DQTAhstrkqred---afislertWITFCQAAMMDCFAADTMDLLGVHLTAHSMRvQDFKG 1720 Serendi...
WGS:AEVR:RTG_02571 1870 AAFSGDEEAVAATAALCL-PKDAsrp--------------pteFEAFSASVLLECLTKDKRDVAPIYRAVYSAI-KDLEA 1933 Rhodoto...
KDE02819           1796 NSFSDDVEALAMVSYICDpSSTRykp--------------pteFEAFASTVLLECLTRDKKDLVGVYHGLFHAK-QLEEE 1860 Microbo...
XP_017994135       1412 RGFPTAPDAQGFVSYLCQ-STTTh-------------------FGAYCTAALLDSLLRDAPMLTRFYLALWSGW-ADAHA 1470 Malasse...
KNF00731           2097 EGFDLDEQSTGLVDYLGS-LSSLspsrrrrkvghgngkgsvvdLSAYASTTLLQCLLEDKLEIFPTYLALFACS-KSAVD 2174 Puccini...

5A31_A             1336 re----------msETSELWQIKLVLEFFSSRSHQ----------------------------------FMNSEFLPVVK 1371 human
Q5KGI0             1762 rsrdpvlssseifdGMEDIVQSGLIKSFYDEHYEKnfaqvna--------------------agekrfaLVRHSFINAAR 1821 Cryptoc...
KZV91613           1694 y------------pSSLGLKDFAVATSFYTRAHGTvfsetl----------------------kaggsqLFSASTLADVN 1739 Exidia ...
KLO17751           1780 rs----------ryFQLEQQEITRVAEFYLRLFERrfsgrte---------------------gitrpsLIRESSVVSAV 1828 Schizop...
KDQ11269           1955 ss----------plATLAVRDLLFAAEFYNLYYLNsyggcvd---------------------rafrppLIRPQLLQGAL 2003 Botryob...
CCA69952           1721 ss----------saMSGNLADLTALSEWYGSANIRgp-------------------------------tLLRTQLIKSIL 1759 Serendi...
WGS:AEVR:RTG_02571 1934 alnsps--snssstALLETDDLRFVIEFYKLGAFKsifsrvgapgpsss------ssksksgsstsrepLLHPSFISHLS 2005 Rhodoto...
KDE02819           1861 h------------gKIWAQEQISFIVDLYGNKVFGtlfgdgktsstkra-------tsktgstpsvkekLFRSAFIDYLA 1921 Microbo...
XP_017994135       1471 s------------dAILAIRDVQHIQQWYGSQTDHmvrg--------------------------srerLVPHDVVDSVL 1512 Malasse...
KNF00731           2175 yrtrl-----vtqyIPDQEWQISNLVRFYGEEQCLneigpkspspssssfsspsppsstatsssfsstsLLDRSLLIQIQ 2249 Puccini...

5A31_A             1372 CTIDNTLDQWLQV--GGdm-cVHAYLS----------------------------------PL-ESQLSMLACFAVYHSV 1413 human
Q5KGI0             1822 RSVLESSSEETEE--SHr--aIEYMLKg--------------------------------lSAwESDARKIAKWLARNGV 1865 Cryptoc...
KZV91613           1740 QSLHASVQGLRCEd-AFka-mLARYSMghgi---------------------------dvtRDaPKAWRMFAAYLVAENV 1790 Exidia ...
KLO17751           1829 NAVSDRLRKISDSpeLQr--aIRAYILnqrdsp-----------------------dlqetDSyPDLNHHIAWYLSKHAV 1883 Schizop...
KDQ11269           2004 HAIDDRLAEYRSDp-Afl-avLDQYLRgedvsagtemp-------------sqepaepasyNKrKRLSRQLVIYLARESV 2068 Botryob...
CCA69952           1760 LVGQSKVDALRHN--SSfmtqLRHYANgrgiq-------------------------etdpSArRALGRQLGFYLTHTNT 1812 Serendi...
WGS:AEVR:RTG_02571 2006 STLSALGSGAVSGg-GSn--vFERYLRelg-----------------------------ewPTdSHLSTRLSLALSHLRL 2053 Rhodoto...
KDE02819           1922 QPPKPVASHVDDS--SSs---LRDYVLhg------------------------------rwPSdPIQGQAFSLYLVHHRA 1966 Microbo...
XP_017994135       1513 WAWERALPSVQAD--TQa------YVRg-----------------------------------eRVDLTQVAWALQVLHT 1549 Malasse...
KNF00731           2250 HSHQQEVMKWADLprGTq--lILRYLKsngeislanhsinepnsasstpnldeaginqdpdDRlKFDEQRLLDWLRLMNV 2327 Puccini...

5A31_A             1414 P 1414 human
Q5KGI0             1866 P 1866 Cryptococcus neoformans
KZV91613           1791 P 1791 Exidia glandulosa HHB12029
KLO17751           1884 P 1884 Schizopora paradoxa
KDQ11269           2069 P 2069 Botryobasidium botryosum FD-172 SS1
CCA69952           1813 P 1813 Serendipita indica DSM 11827
WGS:AEVR:RTG_02571 2054 P 2054 Rhodotorula toruloides ATCC 204091
KDE02819           1967 P 1967 Microbotryum lychnidis-dioicae p1A1 Lamole
XP_017994135       1550 P 1550 Malassezia pachydermatis
KNF00731           2328 P 2328 Puccinia striiformis f. sp. tritici PST-78
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