3QHE


Conserved Protein Domain Family
Sam68-YY
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pfam16568: Sam68-YY (this model, PSSM-Id:406871 is obsolete and has been replaced by 465182)
Tyrosine-rich domain of Sam68
Sam68-YY is a short tyrosine-rich domain on Src-associated in mitosis, 68 kDa protein (Sam68), a protein that regulates TCF-1 alternative splicing. It is a crucial binding-partner of the APC-Arm domain that forms a superhelix with a positively charged groove, the surface-residues of which groove form numerous interactions with Sam68-YY to fix it in a bent conformation. APC-Arm is the armadillo repeat domain of the tumor-suppressor protein adenomatous polyposis coli or APC. APC plays plays important roles in Wnt signalling and other cellular processes.
Links
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Statistics
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PSSM-Id: 406871
Aligned: 29 rows
Threshold Bit Score: 40.1029
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3QHE_B         2 YEEYG-YDDTYA----EQSYEGYE-GYYSQSQGDSEYYDYGHGEVQDSYEAYGQDD 51 
XP_010816377 267 YEAYG-Y-DGYGgeydDEIYETYDnSYPIQAQSVPEYYDYGHGVSEDAYDSYAPEE 320 cattle
XP_023417562 285 YEEYG-YDDGYGeeyeEQTYQAYDhSYAPQTQSVPEYYEYGHGVNEDAYDSYATEE 339 domestic guinea pig
EHB16826     237 YEEYG-YDEGHGghyeEQSYEAYDsSYATQAQSVPEYYEYSHGVSEDAYDSYAPEE 291 naked mole-rat
2_pfamImport   1 YEDYG-YDDGYGgeydDPSYEAYDnSYATQTQSVPEYYDYGHGTSEEAYDSYAQEE 55 
NP_001072215 263 YDDYG-YDDGFGedydEQSYDIYEnNYNSQTQSVSEYYDYEHGTNEESYNHYEQEE 317 tropical clawed frog
XP_006638759 274 YDDYG-YDDGYDgeydNQTYDVYDdSYSSQTQSIPEYYEYGHGTGDDAYDSYAEED 328 spotted gar
3_pfamImport   1 YNNYQgYDDGYEde-yDESYEAYEeDYSSQSK-ISEYYVYGCGTSDEAYNSY---- 50 
XP_014833904 371 YDDYG-YEDGYDeeyeDETYEAYDeNYSTQTKSISEYYEHGHGTSDESYNSY-EEE 424 Poecilia mexicana
XP_013124439 263 YDDYA-YDDGYGgeydDESYEAYEdNYSNQSKSISDYYEYGQGTSDESYNNY-EEE 316 Nile tilapia
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