Conserved Protein Domain Family
Casc1_N
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pfam15927: Casc1_N (this model, PSSM-Id:406371 is obsolete and has been replaced by 464947)
Cancer susceptibility candidate 1 N-terminus
This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is approximately 200 amino acids in length. The family is found in association with pfam12366. There are two completely conserved residues (N and W) that may be functionally important.
Links
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Statistics
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PSSM-Id: 406371
Aligned: 31 rows
Threshold Bit Score: 126.303
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EFJ46480            31 RLA--EEERLRAEEaERQRLAELERQRLELLEQFl-AAERARLDVELDELGPLFRQFEHERVRSRNEALEAAEWERFLRC 107  Volvox c...
XP_015837770       512 RAA--ELERIRLEE-ERKAAIEKEKRE---------TFEQQIRMEQLEVALQYINDVVRYNKKLRHDAKVQEDWEFYVNC 579  red flou...
2_pfamImport         4 EAE--ELSRMRLARlIEIKNLQEDAKLREKRS----INEHSIRLYILEKNVRLFESVKKKFLDDRINMRQEDEWRQYLCC 77  
CBN79221            32 LRAkrEAERIRKEA-EDAKRLKEEQIADR-------TEELERLSNELQEAQDQIAETKERLRWAEKLEAVQSSWETYTKC 103  Ectocarp...
EFJ08772            30 RKA--AEEKLRLEE-EERQRIAEEARLAWEAEQArlKAEHDRIVGEWESLEPVLKRRREGLAKHEARYDGAAEWKRYVEP 106  Selagine...
EEH53508            50 LRI--EQERIAAEE-AERARIEAENKAISDLEYEriAAADAIKAAELAEVTPFLDERRAALEAHRAEVKDAYEWERHLAT 126  Micromon...
jgi:MICPUN_104583   33 RARreEEARLAREA-EDREFEREEAERV--------AAEDATLAPTREESAGFHARRDAALARRSLNARDEYEWERTARC 103  Micromon...
XP_001315841        71 KLEqlERERQQQLA-EKANREAEERRKREREMA---LAGQQRLQNEETQLKEFREARILNNATIRADAAKQTDWETYLQC 146  Trichomo...
XP_001580967        50 KREkaEQERLEQEKlEAAKKAQQEKEEESRKR----AEQQQRLEEEKEYIKNFRLQKEEKIQKIVANFEKTEDWELFSQC 125  Trichomo...
XP_004995304        24 QRE--EEERLQKEA-EEALKEQKRLRDKLLRD------QADRFKDEVVLVKDKYMLLQQALERLHEEEEDAKQWRRIVEC 94   Salpingo...

EFJ46480           108 VRVPAPRQRVEVNEFLLRMNESSRee-------dsRSLEEAFLTCedcrTMVLET---------------------RQAL 159  Volvox c...
XP_015837770       580 GRLPNPAKCDQMNTFLHLWENVIEq----------TTMEEAAKRT----VDMLEL---------------------LNEL 624  red flou...
2_pfamImport        78 DRLPLPSDPSSMNTHLYYWSSLKEa----------EFMDNILEWI----EKYIAL---------------------LSDL 122 
CBN79221           104 DPRPDAASEKALNTFLSQGADEEV-----------PELDQAMERCvygeSIAADL---------------------LNDI 151  Ectocarp...
EFJ08772           107 GPLPYAGNDPSMNGYLNVMAEGYD-----------KDINDVMRTL----TDIYSVrylrascdkhdtaflskifagAEEL 171  Selagine...
EEH53508           127 SALPDPQREKEINTYEMAITDEE--------------------------TRLLGP---------------------ALEL 159  Micromon...
jgi:MICPUN_104583  104 VSTPDPRDGRAFDEWVHVVDATPPlp--------fADAFELMETC----------------------------------- 140  Micromon...
XP_001315841       147 DHSTNPLDKADVNSFITLWREAED-----------TNMPVLFEHI----ATVVKL---------------------INQL 190  Trichomo...
XP_001580967       126 SHAIDVRSEADVNTFISQLSEVNE-----------TDINQLFEHI----HLAKVI---------------------ENQL 169  Trichomo...
XP_004995304        95 HDTPALTDTRAVNTYLSQWLNESMrvdlnpaeeahVDIKKRMQEI----TQAYKL---------------------AAEA 149  Salpingo...

EFJ46480           160 letRNRVVgsGGPEEEASRKaLE-------------------SDIR-----ELYAIINARIDRFTAAVLHHCDEYANERN 215  Volvox c...
XP_015837770       625 ---DDLI----DTAEETDQSvIDnw----------------kWVRL-----LFRQQQAKSLDVATYRLLRDIERNLHRID 676  red flou...
2_pfamImport       123 ---ERLI----EEPLDATPTkVEnw----------------kEVRE-----SYRSEIFKKFDQGTFHILRKIETKMNRID 174 
CBN79221           152 ----------GQSLENGDISrMArn----------------eEFLE-----LLRGLSFDKIDFATAHLLSHWDSLSGGDE 200  Ectocarp...
EFJ08772           172 -------A--LVEEQKGRPQlVEky----------------hDYMR-----RLEELANRRLNHNTAYLLEKSHDYYKRTN 221  Selagine...
EEH53508           160 -----------AVDNEKIVNeGDtyrywaiaegrdafadavgGFQK-----RIRALTDVVIDRSTAGIMHTADEYQDENG 223  Micromon...
jgi:MICPUN_104583  141 ---------------ESVAGeCEayrawaaedgdddlraaliIRKR-----VARRLAETVADKATASCLDRANEHQDEET 200  Micromon...
XP_001315841       191 tnlRY------TAEVAAINEdVTrf----------------sEHIN-----DIRSIISQKIELLTQHHLMFSDKYTGAKS 243  Trichomo...
XP_001580967       170 rerSE------KAQLANRVPlYTrc----------------nRQID-----TLQQLINQKIENITVNHLAFSDKFSGAKG 222  Trichomo...
XP_004995304       150 -----------DAQATLAEArGDee----------------eEVVLlrtnkVLRDASMTKLTNMITKLLQFPDMNTREFE 202  Salpingo...

EFJ46480           216 EIQLGHVAGT-----FKWGVWVNTA-----KNPR 239  Volvox carteri f. nagariensis
XP_015837770       677 IPTADYKYQDd---nIVLCLWLRVQlptplPNPR 707  red flour beetle
2_pfamImport       175 YWTVDYKRITk---nVKICMWAWL---------- 195 
CBN79221           201 DFDRTCMTAGg----IRVGVWVNVSl----KGFR 226  Ectocarpus siliculosus
EFJ08772           222 ECSLFSGQAG-----WKLALWANHA-----KNPR 245  Selaginella moellendorffii
EEH53508           224 EIIVFDSREG-----FKYVLWLNHV-----KNPR 247  Micromonas pusilla CCMP1545
jgi:MICPUN_104583  201 GYVGYVADFNgl--gEWCALWANHV-----KNPR 227  Micromonas commoda
XP_001315841       244 EVLLNAESSG-----YQYGLWVNLA-----KNPR 267  Trichomonas vaginalis G3
XP_001580967       223 DVQINGGSDD-----ITYGMWVNLS-----KNPR 246  Trichomonas vaginalis G3
XP_004995304       203 EDLYVCEQPSttdceAALFLWANLA-----RNPa 231  Salpingoeca rosetta
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