Conserved Protein Domain Family
HPS3_Mid

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pfam14762: HPS3_Mid (this model, PSSM-Id:405452 is obsolete and has been replaced by 464301)
Hermansky-Pudlak syndrome 3, middle region
This domain is downstream of the N-terminus of these vertebrate proteins. This region carries a number of tyrosine sorting motifs and one of two di-leucine sorting boxes at residues 542-548 well as a peroxisomal matrix targetting motif at residues 614-623 in human HPS3. There is also reference to a human Mendelian disease at MIM:614072.
Statistics
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PSSM-Id: 405452
Aligned: 17 rows
Threshold Bit Score: 363.633
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011472511  276 RHQELLESKAKDCDILVTMEK-----TGL--EDQ-AQYQFSYILFRRFSPEFFQGCRVEEMQ--IHSLQLY------PLF 339  Japanese medaka
EEN52758      308 NPTEVLGPVDCVQGRPITVEWaglysVGIsiKGMnAQLSTTTLLYRRFAPGDTAYTTVDGA---LHSLQFL------PTY 378  Florida lancelet
EEC10796      325 NPQEC-------CKVSIAVNPstdlmSGFdgASA------TTLLYRKFNSHTESGKRVEAFHwvPYYLQNEdssfsdPLT 391  black-legged ...
EEB20087      325 NPFT----ATKDLFVNFVTNS-----TSPtsNNAkNEFKAINLCQYHLIPLTLGNIPNREVIekFTFLILK------PYY 389  human body louse
XP_006007914  256 QPVELLGTDASTSGLLITLES-----TGLenEQS-SCLQVCHILYRQFAPDYSQISSAEETS--LHSLQLV------PMY 321  coelacanth
XP_015147341  261 KPVELLGEESKLCKIPVTLES-----TELstEDK-KHFEVQYLLFRRFTPDQSPFGFCEETK--LHSVQFL------PVY 326  chicken
XP_003766113  265 KPTELLGEVSRQSGLSITLES-----VGLkeEKA-GPSRVHSILYRRFTPDVS-YVLPEDTR--LHSLQLL------PIY 329  Tasmanian devil
ELK00543      234 KPMELLGEKSEQSGISITLES-----TGLddEKI-NYFHVQHLLYRRFAPDISSYVLSDDIK--LHSLQLL------PIY 299  black flying fox
6_pfamImport    1 KPMELLGKKSEQSGLSITLES-----TGLadEKL-QYVHVQHLLYRRFAPDISAYVLPDDIK--LHSLQLL------PIY 66  
KAE8604320    206 RPMELISEECKMCGIGVSPED---------------CTQVCHLLYRRFAPDFTEGIHVENTR--LHSLQLL------PMY 262  tropical claw...
XP_011472511  340 T---------S--------------NSLE-----D-PTCVFCFFSLPTAGYL----YSLKGGVE------LLSA-YQYPE 379  Japanese medaka
EEN52758      379 SkdgadksekSrrhrvsvlpaegrcSPLHpnpqeGtLHGLCCFFTGPRQGFL----YDIFDGAN------LLAS-YPYTA 447  Florida lancelet
EEC10796      392 AalsleseplK--------------NVLQsqlftK-LHTLACFVSCTDQGYF----YNLNNAKAt----tLLSI-YKYSN 447  black-legged ...
EEB20087      390 SherklkkykN--------------DLLEseyypN-LKSIACFFGTQQEGYLqcfeYNNKDDDDtvtcgnYFT--YAFTA 452  human body louse
XP_006007914  322 YtgnlvsdgqP--------------KRNEr----K-LLSLFCFFSLPHFGYL----YNIKSTIE------LIST-YQYPD 371  coelacanth
XP_015147341  327 QtgssvtaneE--------------TENKr----E-LLSLFCFFSLPHVGYL----YSVGKLVE------LIST-YQYSE 376  chicken
XP_003766113  330 QtgavsadgkS--------------SPQEk----E-LLSLFCFFSLPHIGYL----YMAVKSVE------LMSV-YQYPE 379  Tasmanian devil
ELK00543      300 QtgsltsdrkN--------------SSQEk----E-LLSLFCFFSLPHVGYL----YMVVKSVE------LMSI-YQYPE 349  black flying fox
6_pfamImport   67 QtgtfdskleE--------------KVPRk----E-PRNL--AFQIPRIIWL----SILTVVNR------LGSCrWRFLS 115 
KAE8604320    263 KtgisfatdpK--------------SATPq---kE-VLVMFCFFSMPHTGFL----YSIGSTVK------LLSL-YQYPE 313  tropical claw...
XP_011472511  380 KVLQAVMSDHLLHVITKNALQCFTVRCSAVAARMEDPYIDTTM-KACPPSTLEVCALRIQLFIGLRSVCVYNQRVILLSA 458  Japanese medaka
EEN52758      448 DTSKVVAGDSLLHAVTRNGLETYTLRKFAAAVHRMED-IDNIH-NTCPHPNMDICLIGMRPFIAIQDISVCTSHVLLLSK 525  Florida lancelet
EEC10796      448 DIKGVALDECFLHALTSTGLETYTLPIP------YQPLVQTSKeKEVP--TKPAIMIGLRPFLGLGTLVMSDHHLILASS 519  black-legged ...
EEB20087      453 PIIDVKLEDCFLHAITEIGLETYTLR-AAKHLYKKNENVD------CPSLTDPVCLIGLHPFVNLFQSCLTNNYLTLFAN 525  human body louse
XP_006007914  372 KSQQVVLSPQFLHVITRNSLQCFTVRCSAVAARDEDPYVDTTL-KACPPVTMGVCALRIQLFIGLQALCHFKNHIILLTK 450  coelacanth
XP_015147341  377 KSEQAVLTPQFLHVITSESLQCFTVRCSAAAARDEDPYIDTTV-KACPPVTLDVCTLRMQLFIGPRAICHYKNHIILLTK 455  chicken
XP_003766113  380 KSQQAVLTPQFLHVITSNNLQCFTVRCSAAAARDADPYVDTTL-KACPPVSLDICALRMQLFIGLKAICHFRNHIILLTK 458  Tasmanian devil
ELK00543      350 RSQQAVLTPQFLHVITSNNLQCFTVRCSAAAAREEDPYVDSTL-KACPPVSMDVCALRIQLFIGLKAICHFKNHIILLTK 428  black flying fox
6_pfamImport  116 GGAAVLITTDDNQALTVGSLGSFTVQKQPGVVERGRGYMDTTL-KACPPISMDVCALRIQLFIGLKAICHFKNHVILLTK 194 
KAE8604320    314 TSQQAVLTPQFLHVITRNNLQCFTVRCSAAAVREEDPYIDTTM-KSCPPVSMDVCTLRMQLFIGLKAIAHFKNYLIILTK 392  tropical claw...
XP_011472511  459 ADTETQQEPERRCL---SRKWTISSPKETSTVGHGWNLYVVDTVHPFTLYQEMVEYSCRYVQTTpqSHSLRHLLSEAHLL 535  Japanese medaka
EEN52758      526 VE---------------------SPRTQRVAGQSHWSLYALQNASVGQLYKDMLDLGLRYQNSS--PPAYHQLLCEGHLL 582  Florida lancelet
EEC10796      520 NDD--------------------CSSSSDSIELVSSTLYSLLKPTMSQLFYDLKEAASVYKNEE--RQAYMSALKEGLLI 577  black-legged ...
EEB20087      526 NE------------------------------ESSSTLYQLKLPDIMTVWNDFLTSAEENKWES--PLTYSELLGEGHLI 573  human body louse
XP_006007914  451 ADG------REGGRg--lRRKSSKMAAGKQESEPGWNLYIVNTVPTIQLYNEMVEYCKKYETAN--PQSYRHLLSEAHMM 520  coelacanth
XP_015147341  456 ADTEDITERRKPSRrmlSRKADSNKSRTNSESEPGWNLYIINTVSTIQLYREMVDYSRTYENVR--TESCIHLLSEAHLL 533  chicken
XP_003766113  459 AGTEDIPERRKLSKsllSRKDGSIRHKSPSAMEAGWNLYIVNTISTVQLYKEMVDYSKTYKNMR--TQSCIHLLSEAHLL 536  Tasmanian devil
ELK00543      429 ADPEAIPERRESPKkllSRKGTSVKLKTSPVAEAGWNLYIVNTISPVQLYKEMVDYSNTYKTAK--TQSCIHLLSEAHLL 506  black flying fox
6_pfamImport  195 AEPEAIPERRDSPRrllSRKDTSGKSKIPPVAEAGWNLYIVNTVSPVQLYKEMVDYSNTYKTAK--TQSCIHLLSEAHLL 272 
KAE8604320    393 TNMEATEERRVSTSqr-qRSKKPVKNKTAQDAEPNWNLYVVSTTPTVQLYKEMVEYSKRYETAK--TQGSIHLLNEAHLL 469  tropical claw...
XP_011472511  536 LRAC--LLQ----TPEQKQsgqgdpavsskpgsngavdknsatqanrqELEEALRQNSAQLG-DCF----SRAS-QkDCH 603  Japanese medaka
EEN52758      583 LRQA--LFSqeagSRTQ-------------------------------QLQDLLCESCGLLG-DYH-----SLPdSqDWT 623  Florida lancelet
EEC10796      578 LKTQ--ILLqgrsRCNS-------------------------------ELMAAYSDSCCLLGdLCL-----KSDsEvERE 619  black-legged ...
EEB20087      574 LKTKlnTFEwsweKDANKNslcyakp---------------ttpnsndNVKSLYKESCALFG-DYH-----ILNk--NYQ 630  human body louse
XP_006007914  521 VRAA--LMDcslkESPEKE-----------------------------ELMVAFRESCAKLG-DTY----CRAD-EkHFH 563  coelacanth
XP_015147341  534 VRAA--IMDrsffKSDEKE-----------------------------ELLRAFRESCALLG-DCY----SRFD-TkDYH 576  chicken
XP_003766113  537 VRAA--LMDpcltEPGEKE-----------------------------ELLEAFRESCGHLG-DCY----SRLD-TqYSH 579  Tasmanian devil
ELK00543      507 VRAA--LMDgsqlEPGEKA-----------------------------ELLDAFKESCGHLG-DCY----SRLD-TqYSH 549  black flying fox
6_pfamImport  273 VRAA--LMDasqlEPGEKA-----------------------------ELLEAFRESCAHLG-DCYnflpSRLD-TqHSH 319 
KAE8604320    470 VRAA--LMDpnleESLAKT-----------------------------ELVAAFKESCAHLG-DWF----SRLG-TkHSH 512  tropical claw...
XP_011472511  604 LALPYYKMSGLTVAEVISRNRPPPEGPS-----SYG-----LGFLFYLKLHLL-----------EETEQHLTQEEADEII 662  Japanese medaka
EEN52758      624 LALPYYNMSGLKMAAIVQQ--ALHQMQPdreqpGYG-----RGLVHFLDHVLFi----------GDEPLETDKSTSNIVL 686  Florida lancelet
EEC10796      620 QAAQYYDISEEIPETIIKRIMLFKGQIKt---sSLT-----RGAIQYVKLAMCars-----lesRKAMEGLSQATADAIL 686  black-legged ...
EEB20087      631 SCYCYYSMSEYKILDIIKRIKNLKNNVPgkyrdDYEegditKGLIYFLKKKLShydlkyyefsgSNREEFYNSEIGNLVT 710  human body louse
XP_006007914  564 LALPYYRMSSLTMADIVKRGMHVEKSGM------FG-----NGFMFCLRHLLQ-----------EEITEVLSEETAANVL 621  coelacanth
XP_015147341  577 LALPYYRMSGLSVTEVLERRVSESDEIQ-----AYE-----RGFIFYLTHSLN-----------EELNEELSKELADKVL 635  chicken
XP_003766113  580 LALPYYKMSGLSMTDVLTRIDSVVEDGSq----NAE-----RGLLFYINHSLY-----------ENVDEELSEELAAKVS 639  Tasmanian devil
ELK00543      550 LALPYYKMSGLSMAEVLARVDWAVEDGSq----KYE-----RGLIFYINHSLY-----------ENPDEELSEELAAKVV 609  black flying fox
6_pfamImport  320 LTLPYYKMSGLSLAEVLARVDWTVEDMSq----KYE-----RGLIFYINHSLY-----------ENLDEELTKELAAKVV 379 
KAE8604320    513 LALPYYKMSCLSISDIINRVVGMEMLPG------YG-----RGFLFYLKHVLF-----------EEQDEQLSEAVAVKVI 570  tropical claw...
XP_011472511  663 YIFSQSEP--F 671  Japanese medaka
EEN52758      687 EAYSQLEPesL 697  Florida lancelet
EEC10796      687 DVFAEECPdaL 697  black-legged tick
EEB20087      711 SLMDLLetvek 721  human body louse
XP_006007914  622 YIFSVADPhqL 632  coelacanth
XP_015147341  636 QIFYLADPvqL 646  chicken
XP_003766113  640 QIFSAAEPkqL 650  Tasmanian devil
ELK00543      610 QMFHVAEPkqL 620  black flying fox
6_pfamImport  380 QMFYVAEPkqL 390 
KAE8604320    571 EIFNAVDKaqL 581  tropical clawed frog
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