Q5U2V9 42 AIGLPVPPTtALITPGPVRHCQIPDLP-VDGSLFFEFLFFIYLLIVLFIQYINIYKTVWWYPYNHpASCTSLNFHLIDYY 120 Norway rat NP_955926 42 AVGLSAPPLtALITPEPVRHSRIPDLP-LDSNLLFETLLLLYLLVALLVQYINIYRTVWWSSYSQpTASTSLNFHLMDAH 120 zebrafish XP_006639253 42 SVGLSAPPItALITPEPVRHSRIPELP-LDGSLLFEFLLFTYLLVALFVQYINIYKTVWWYPYSHpAASTSLNFHLIDYH 120 spotted gar XP_003727503 47 ggGGSNTPLtTLITITPIRHPDIPNLP-AECSLLFETHTVIYLLTALFLQYINIYKTVWWLPLA--PSNTAMNFHLIDPF 123 purple sea urchin EDO41973 64 SIGTVRQTIsSLLTIPQLYHIPIPRVP-IFNAMGFEILFFAYLVSALGLQYLNIYK---------------LNFHVVDVH 127 starlet sea ane... EKC27988 30 drdtnMVPL-AQMAVLP-KHCHLPEIP-SDPNMSFEAMLYFFGVIAMGLQYINLYRTVWWLPHSH--ANYALNFYLIDVY 104 Pacific oyster EFO84726 15 atvTVPPPRtSGVTLS--VHPIWPDIQfTQGELFFECTLFLYSVLALFLQYLNIYKTLWWLPKSY--WHYSLKFHLINPY 90 Caenorhabditis ... XP_001959491 26 KPGQAQTPA----TAMP-KHIPFPDHA-TTSEWLSELIMCAFTMGSAIVQFINIYRTNWWLPQAH--TRHMVNIDLIDPH 97 Drosophila anan... Q7ZW11 48 GTGMSSPPL-ATQTVVPLKHCKIPELS-MDKNVLFELHLFACHLIALFVHYVNIYKTVWWYPPSHpPSHTSLNFHLIDYN 125 zebrafish 2_pfamImport 1 GTGLSSPPL-ATQTVIPLRHCKIPELP-VQPSILFELQLFFCHLVALFVHYINIYKTVWWYPPSHpPSHTSLNFHLIDFN 78
Q5U2V9 121 LAAFITVMLARRL---VWALISEATKAGAASMVHYT--ALILARL---VLLTLCGWVLCWTLVN--------LFRSHSVL 184 Norway rat NP_955926 121 LAVFIAVMLSRRL---VWTLLSEVCVACPASPLCYV--LLLVVRV---CVLTLCGWVLCWTLLN--------LFRSHSVL 184 zebrafish XP_006639253 121 LATFITVMLARRL---VWTIISEASQTGPTSVVRYT--VLIAARL---TLLTLCGWVLCWTLVS--------LFKNHSVL 184 spotted gar XP_003727503 124 LLIFVTLVLIRRL---VWHFIIELTP--------IV--TIVTARY---CVLQVIKLIITLTFLNlglwclwqLMNNNSPL 187 purple sea urchin EDO41973 128 LVTFILIFLSRRL---IWNILKQTLA--------SE--ILFTVKYflgLIFKAVIFLVVICTLTwll---wkLFQHNSIQ 191 starlet sea ane... EKC27988 105 LVLFLCILMSRRI---VWCFVQEVYG---SRFSKSV--LFWVVQFlkgALLGSIALGLVYTAYM--------VVANHSAL 168 Pacific oyster EFO84726 91 FLSCVGLLLGWRVtvcFWKTITEVIAAISANQSQFVqsSLMIVEY---AAIKTPVMTLIITSFLfsfnrvchDFPSRSVL 167 Caenorhabditis ... XP_001959491 98 LRYLLFILNTRRL---IYCLLL-IKIRKFDENTQNW--IRLGVKY---GFGGLVQLGLGFCAVK--------LYQQHTYI 160 Drosophila anan... Q7ZW11 126 MLVFTVIVLARRL---IAAIVKEASQSGKLSFPHSV--FLVTARF---AVLTLAGWSLCRSLIY--------LFKTYSVL 189 zebrafish 2_pfamImport 79 VLAVTTLVLGRRL---IGAIVKEASQSSKVSLPCSV--FLVITRF---AVLTGTGWSLCRSIIH--------LFRTYSFL 142
Q5U2V9 185 NLLFLGYPFGVYVPLYCFHQDSRAhlllTD--YVVQHQAvedaasnVGSLTR-SKDFLSLLLESLKEQFn----NSTPI- 256 Norway rat NP_955926 185 KLLFLGYPFGVYVPLCCLHQDGSPa---ADcgFADADGA-------DGALLQ-PRDFLTLLRENLRQQL-----SGTHTh 248 zebrafish XP_006639253 185 NLLFLGYPFGVYVPLCCFHQESRTqtlpADcgYLEQEQM-------DGPLLR-PKDFLTLLRENLREQFn----SPTSI- 251 spotted gar XP_003727503 188 NLLFLAYPLISYFLLYGLTLDFNMtlfsQ-----------------LAPPAKgSKEELlw-------------nGITMLa 237 purple sea urchin EDO41973 192 NCLFLLYPIVMYLCAFGFTLDPQGnkv----------------mfkISPHVEiSQIHLIPTRTMEKKAFqngdaRQELI- 254 starlet sea ane... EKC27988 169 YCLFLSCPVITYVFLFG-----------PSikPLYHRCLvwptsvcDRPRHKkEEEEVILF------------------- 218 Pacific oyster EFO84726 168 WFLF---PVFFYVFIF----------------RSEIIGWlrkfrelVGKWRRkESDFSTICERLTESPp-----AQIDLd 223 Caenorhabditis ... XP_001959491 161 LLLFLSYPVIIYLFIFGFQLE---------------------------PFLR-TRFELp---------------GVYINd 197 Drosophila anan... Q7ZW11 190 SLLFLCYPFGMYIPFFRLSCDFRRa---GSmsPLSGIGSkd---vgAAALGRgGRDYLSVLKETWKQHTsq-lySAQPM- 261 zebrafish 2_pfamImport 143 NLLFLCYPFGMYIPFLQLNYDFRKt---SLftQVANIGPreaggsgSSPPSR-GRDYLTVLKETWKQHTqq-lyGAEAM- 216
Q5U2V9 257 -PTHSCPLSPDLIRNEVECLKADFNHRIKDVLFNSLFSAYYVAFLPLCFV-KST-------QYYD-MRWSCEHLIMVWIN 326 Norway rat NP_955926 249 tHTHTCPPSPELIRSEVQQLKTDFNRRIKEVLFNSLLSAYYVAFLPLCFV-KST-------QYYD-MRWSCEHLIMVWIN 319 zebrafish XP_006639253 252 -PAHTCPLSPDLIRNEVECLKADFNRRIKEVLFNSLFSAYYVAFLPLCFV-KST-------QYYD-MQWSCEHLIMVWIN 321 spotted gar XP_003727503 238 pAKHKCSHVPNEIRQEADLLKMDFNSRVKSVLFNSMVCAYYVGFVPICFL-QPA-------MYLD-LWWSCFLIAFVWIN 308 purple sea urchin EDO41973 255 -GKPNCTLPPDAVRYEAECLRTDFNSRIKQVLFQSLLCAYFVGFLPMRFSeQHH-------VYYD-LWWACQQILFIWLS 325 starlet sea ane... EKC27988 219 ---HNCVLTPDVIRSEVEYFKLDFNNRIKQVLFNSLLTAYYMTFVPLCFA-QNT-------LYYD-TWWVGQHVVVTWLS 286 Pacific oyster EFO84726 224 sVLHMCSDNPAQIREEIQVLIDDLVLRVKKSIFAGVSTAFLSIMLPCIFVpYKTsqgipqkILIN-EFWECQLGIVVGLT 302 Caenorhabditis ... XP_001959491 198 mPVHSCTTNAVHIRDEVETLRHDFNRRFKQLIFTSMLNAYYSGLVPCCLA--VS-------VQYN-VIRAAQHCLGVCLG 267 Drosophila anan... Q7ZW11 262 -PTHACCLSPDLIRKEVEYLKMDFNWRMKEVLVSSMLSAYYVAFVPVWFV-KST-------QYVD-KRWSCELFILVSVS 331 zebrafish 2_pfamImport 217 -PTHACCLSPDLIRNEVEFLKMDFNWRMKEVLVSSMLSAYYVAFVPVWFV-KVS-------ATVDiKCFPPSSLYQLHLA 287
Q5U2V9 327 AFVMLTTQLLPSKYCDLLHKSAAHL-------GKWQKL---EHGFYSNAPQHI---WSENTIWPQGVLVRH-SRCLYRAM 392 Norway rat NP_955926 320 AFVMLMSHLLPPHYCDLLHRCAAHL-------GRWQRL---EPGSCSNTPQHT---WSDSTIWPQGVLVRH-SRCLYKAV 385 zebrafish XP_006639253 322 AFVMLMSQLLPPKYCDLLHRSAAHL-------GKWQKL---EHGSYSNAPQHV---WSENTIWPQGVLVRH-NRCLYKAV 387 spotted gar XP_003727503 309 SFVMFGSHFLPVAYCDALHRCSLHL-------GRWQKM---EHG-YSNTPQHL---WSDTTVWPQGVLVRY-NKGIYRAT 373 purple sea urchin EDO41973 326 SLLVLMMYMLPLTYCDALHKCAVHL-------GGWERY---TCG-HRETP-HV---WSPLTVWPQGVLVRH-NKLLYKGL 389 starlet sea ane... EKC27988 287 AFLMLIVHYLPPKYLDLLHRTALHL-------GRWQKV----EGRHAHVPYNA---WSELTVWPPGALVKH-VKGLFKAE 351 Pacific oyster EFO84726 303 AFSLYVAYLSPLNYLDLLHRAAIHL-------GSWRQIegpRIGHTGSMISAPt-pWNEFCLYNDGETVQMpDGRCYRAK 374 Caenorhabditis ... XP_001959491 268 AFSLCAVFLYPAKYSDTLHRATLHL-------GCWQRI---GTVPVQLIAAANaptWSKYSSYGHGTVVKH-NGGLYRSH 336 Drosophila anan... Q7ZW11 332 TSVILMRHLLPPRYCDLLHKAAAHL-------GCWQKV---DPSLCSNVLQHI---WTEEYMWPQGVLVKH-SKNVYKAM 397 zebrafish 2_pfamImport 288 SFLLVQSSSLPQP----VDASPTHIprdgiqaGDW----------CDKTLLGSsprWTEECMWPQGVLVKH-SKNVYKAI 352
Q5U2V9 393 GPYNV----AVPSDGSHARFYFLFHRPLRVLNLLILIEGSVIIYQLYSLLRSE-KWNHTLSMALVLFCNYYVLFKLLRDR 467 Norway rat NP_955926 386 GPYNV----ALPSDVSHARFYFLFHKPLRLLNVLIGIECSVVVYQLYSLLRSE-RWNHTLSLGLILVCNYYVLFKLLRDR 460 zebrafish XP_006639253 388 GPCNV----AVPSDVSHARFYFLFHKPLRILNLLILIEGSVVLYQLYSLLRSE-KWNHTLSLALILFCNYYVLFKLLRDR 462 spotted gar XP_003727503 374 GQQNV----AFPSDRSYARFYFMFHDPLRVLNLFVFLQLGVIATQLYLLIRHS-HWHYVISLSLLLFCNYYVLFKLLRSR 448 purple sea urchin EDO41973 390 GIHNV----AIPGDPHHSRFFFMFESPLRLINWMSASLLALVLYQLVLIIRCH-FWYQLLSVVGMLSFNYVILYRILRDR 464 starlet sea ane... EKC27988 352 GINVT----AEPGNGMHGRFFFLFHQPMRVVNWLLILTWLLVGYQFFCLIQST-EWNHIVCIALVLFCNYYTLFKLLRDR 426 Pacific oyster EFO84726 375 ASHLIrtvaAHPESSRHNTFFRVLQRPHYLINAMCTFEFVLIFIQFWMLVLTN-DWQHIVTFVLLMFANYLLFAKLFKDK 453 Caenorhabditis ... XP_001959491 337 GVVTV----ATPGNTSHARFYKLFHNPTTIYSTLAILQAAVLLVEIGSLSAESvEWHFVLSISFVAFTSMGAFFKLVRDY 412 Drosophila anan... Q7ZW11 398 GHYNV----AVPSDVSHYRFYFFFNKPLRILNILIILEGAMIFYQLYSLMCSE-KWHQTISLALILFSNYYAFFKLLRDR 472 zebrafish 2_pfamImport 353 GHYNV----AVPSDVSHFRFHFFFSKPLRILNILLLLEGAVIFYQLYSLVSSE-KWHQTISLALILFSNYYAFFKLLRDR 427
Q5U2V9 468 IVLGRAYS 475 Norway rat NP_955926 461 LVLGKAYS 468 zebrafish XP_006639253 463 IVLGKAYS 470 spotted gar XP_003727503 449 FILGKVYR 456 purple sea urchin EDO41973 465 WALQGVLA 472 starlet sea anemone EKC27988 427 IILAKAYK 434 Pacific oyster EFO84726 454 IILGRIYE 461 Caenorhabditis remanei XP_001959491 413 LITKDLYK 420 Drosophila ananassae Q7ZW11 473 IVLGKAYS 480 zebrafish 2_pfamImport 428 LVLGKAYS 435
Jiyao W et al.(2023). "The conserved domain database in 2023.",