1PAX,5DSY


Conserved Protein Domain Family
PARP
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pfam00644: PARP 
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Poly(ADP-ribose) polymerase catalytic domain
Poly(ADP-ribose) polymerase catalyzes the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. Experiments have shown that a carboxyl 40 kDa fragment is still catalytically active.
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Statistics
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PSSM-Id: 395519
Aligned: 27 rows
Threshold Bit Score: 139.776
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1PAX_A  155 SEEAKIIKQYVKNTHAATHna--yDLKVVEIFRIEREGESQRYKPFKQ---------LHN--------------RQLLWH 209  chicken
Q09525  312 SEEIAGKIGDCLAMRGPTHc---yKLSLIDAFELKDPNEIPTEAPVEVqevp--kkrGRKstktaaptvpppttKRLLWH 386  Caenorhabditis elegans
E9PYK3  382 TEEFSRVRKEVLQNNRSEQ-----PVDILQIFRVGRVNEATEFLSK-----------LGN--------------VRLLFH 431  house mouse
Q7Z114  460 SAGYQIFIRNFLSNPHHQKaidngEIKILNCYRLDKKLESDNFLD------------VGN--------------VQYLYH 513  Dictyostelium disco...
Q7TMM8  102 KAEFEKIQQLTGAPHTPVPt----PDFLFEIEY---------FDPANSrfye--tkgERD--------------LIYAFH 152  house mouse
Q6DDF6  129 KDKYEEIQALPGSPSHALPt----PDFLFELEY--CEKLSAKFQETRG---------DRD--------------LIYAFH 179  African clawed frog
Q6NX05  107 KEEFARLSQLAQREGVSAPa----PDFLFELQY--CDLLNSKFERTRA---------GRD--------------LIYAFH 157  zebrafish
Q8CIE4  776 SQEFQDVVRAFYSTLDAVHg----RIRIVRVERVSHPLLQQQYQLHREr--------LMQscqq-------rpvEQVLYH 836  house mouse
Q8QGB0  100 SKEGHDIEKEFRKTLL--------NNTILTIERVQNDSLWKSYQIRKKllee--knkHTNn-------------EKLLFH 156  rainbow trout
Q9NR21  147 THEYNEVANLFGKTMD--------RNRIKRIQRIQNLDLWEFFCRKKAqlkkkrgvpQIN--------------EQMLFH 204  human

1PAX_A  210 GSRTTNFAGILSQGLRIAPPEAPVTGYM-----FGKGIYFADMVSKSA--NYCHTsQADPIGL----------------- 265  chicken
Q09525  387 GTRVTNVFSILMNGL--QFPVGDRCGLM-----FGNGVYFANVPTKSA--NYCCP-EASKRVF----------------- 439  Caenorhabditis elegans
E9PYK3  432 GSPVRNILGILSRGLLLPKVAEDRGVQRtdvgnLGSGIYFSDSLSTSI--KYAHAgETDGSRL----------------- 492  house mouse
Q7Z114  514 GSKPQNLVGLLSRGILPPDYVKQIGGKRtdfgyLGSGIYFSDDV-VSS--TYTSPiGEKGSRF----------------- 573  Dictyostelium disco...
Q7TMM8  153 GSRLENFHSIIHNGLHCHLNKTSL---------FGEGTYLTSDLSLAL--IYSP----HGHGWqhs------------ll 205  house mouse
Q6DDF6  180 GSRLENFHSILHNGLHCHLNKTSL---------FGEGTYLTSDLGLAL--LYSP----HGQGWtrs------------ml 232  African clawed frog
Q6NX05  158 GSRLENFHSIIHNGLHCHLNKTSL---------FGEGTYLTSDLSMAI--LYSP----HGNGWres------------vl 210  zebrafish
Q8CIE4  837 GTSESAVLDICAHGF--NRSFCGRNGTL-----YGQGVYFAKRASLSVldRYSPP-NAEGYKA----------------- 891  house mouse
Q8QGB0  157 GTSSDSITQINNHGF--NRSYAGTHGAA-----IGNGSYFAVNSSYSA--RGYSKaDAQGNKR----------------- 210  rainbow trout
Q9NR21  205 GTSSEFVEAICIHNF--DWRINGIHGAV-----FGKGTYFARDAAYSS--RFCKDdIKHGNTFqihgvslqqrhlfrtyk 275  human

1PAX_A  266 -ILLGEVALGNMYELKNASH-I--TKLPKGKHSVKGLGKTAPdptAT-TTLDGveVPLGNGi-STGINDTC---LLYNEY 336  chicken
Q09525  440 -MLLCEVETANPLVLYESEIdAdeKMEKAKKTSVYAAGKHTP---RDtVEING--IPAFKSnlETIEEETR---LLYDEY 510  Caenorhabditis elegans
E9PYK3  493 -LVVCDVALGKCVNLFKKDFsL--TEAPPGYDSVHGVSETTS-------------VPTD---------------FQDDEF 541  house mouse
Q7Z114  574 -IIMSSVSLGKVKEFSKIQPsL--QCAPSGHHSCKGLKSTPT-------------NPTD---------------FKNNEY 622  Dictyostelium disco...
Q7TMM8  206 gPILSCVAVCE-------------VIDHPDVKCQIKKKDSKE-------------IDRSRAr-IKHSEGGE---IPPKYF 255  house mouse
Q6DDF6  233 gPVLSCVAMCE-------------MIDHPDVKCQAKKKDSSE-------------IDRKRAr-ARNSEGGD---VPQKYF 282  African clawed frog
Q6NX05  211 gPFISCVALCE-------------IIDHPDVKCQVKKKDSES-------------IDRQRLr-ARNSEGGE---VPEKYF 260  zebrafish
Q8CIE4  892 -VFVAQVLTGD--------------------YGQGSRGLKAP--------------PLRVSgqVLRYDSAVdclQQPRIF 936  house mouse
Q8QGB0  211 -MYLARVLVGD------------------YTQGQAGLIVPPA-------------KPSGKD--ADLYDSVTdntSNPTMF 256  rainbow trout
Q9NR21  276 sMFLARVLIGD---------------------YINGDSKYMR-------------PPSKDGsyVNLYDSCVddtWNPKIF 321  human

1PAX_A  337 IVYDVAQVNLKYLLKLKF 354  chicken
Q09525  511 VMFNKEHFKIKYVVEVKV 528  Caenorhabditis elegans
E9PYK3  542 VVYKTNQVKMKYIVKFCT 559  house mouse
Q7Z114  623 VVFNPNQSKLSFLIEYIE 640  Dictyostelium discoideum
Q7TMM8  256 VVTNNQLLRVKYLLVYSQ 273  house mouse
Q6DDF6  283 VVTNNQLLRVKYLMVYSQ 300  African clawed frog
Q6NX05  261 VVTNNELLRVKYLLVYSQ 278  zebrafish
Q8CIE4  937 VIFHDTQALPTHLITCKN 954  house mouse
Q8QGB0  257 VIFSDVQAYPEFLIHSSK 274  rainbow trout
Q9NR21  322 VVFDANQIYPEYLIDFh- 338  human
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