6POJ,2C32,6QF5,1LDI


Conserved Protein Domain Family
MIP

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pfam00230: MIP 
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Major intrinsic protein
MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.
Statistics
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PSSM-Id: 395174
Aligned: 12 rows
Threshold Bit Score: 233.363
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6POJ_A     4 EFKKKLF--WRAVVAEFLATTLFVFISIG--SALGFKYPVG-------------------------Nnqt-----avqDN 49  human
P23645    58 EIRTLEF--WRSIISECLASFMYVFIVCGaaAGVGVGASVS-------------------------S-----------VL 99  fruit fly
P23900   244 KWSSVKNtyLKEFLAEFMGTMVMIIFGSAvvCQVNVAGKIQqdnfnvaldnlnvtgssaetidamkSltslvssvaggTF 323 Saccharomyces cerev...
2C32_A     3 ELRSASF--WRAICAEFFASLFYVFFGLG--ASLRWAPGPl-------------------------------------HV 41  cattle
6QF5_B     3 ELRSIAF--SRAVFAEFLATLLFVFFGLG--SALNWPQALp-------------------------------------SV 41  human
Q08451    45 ELSSWSF--YRAGIAEFMATFLFLYITIL--TVMGLKRSDS-------------------------Lcs-------svGI 88  tomato
P43286    31 ELKKWSF--YRAVIAEFVATLLFLYITVL--TVIGYKIQSD-------------------------Tdaggv-dcggvGI 80  thale cress
AAB67881  11 dslSVGS--LKAYLAEFIATLLFVFAGVG--SAIAYNKLTS-------------------------Daal-----dpaGL 56 
P25818    13 EATRPDA--LKAALAEFISTLIFVVAGSG--SGMAFNKLTE-------------------------Ngat-----tpsGL 58  thale cress
P26587    16 EATHPDS--IRATLAEFLSTFVFVFAAEG--SILSLDKLYW-------------------------EhaahagtntpgGL 66  thale cress
P08995    30 SLVSVPF--LQKLVAEAVGTYFLIFAGCA---SLVVNENYY-------------------------Nm---------iTF 70  soybean
1LDI_A     1 MSQTSTL--KGQCIAEFLGTGLLIFFGVGc-VAA-LKVAGA-------------------------Sf---------gQW 42  Escherichia coli
6POJ_A    50 VKVSLAFGLSIATLAQSVGH--ISGAHLNPAVTLGLLLSCQISIFRALMYIIAQCVGAIVATAILSGITSSL-------- 119 human
P23645   100 LATALASGLAMATLTQCFLH--ISGAHINPAVTLALCVVRSISPIRAAMYITAQCGGGIAGAALLYGVTVPGy------- 170 fruit fly
P23900   324 DDVALGWAAAVVMGYFCAGGsaISGAHLNPSITLANLVYRGFPLKKVPYYFAGQLIGAFTGALILFIWYKRVlqeays-- 401 Saccharomyces cerev...
2C32_A    42 LQVALAFGLALATLVQAVGH--ISGAHVNPAVTFAFLVGSQMSLLRAICYMVAQLLGAVAGAAVLYSVTPPA-------- 111 cattle
6QF5_B    42 LQIAMAFGLGIGTLVQALGH--ISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPAD-------- 111 human
Q08451    89 QGVAWAFGGMIFALVYCTAG--ISGGHINPAVTFGLFLARKLSLTRAVFYMVMQCLGAICGAGVVKGFMVGPy------- 159 tomato
P43286    81 LGIAWAFGGMIFILVYCTAG--ISGGHINPAVTFGLFLARKVSLPRALLYIIAQCLGAICGVGFVKAFQSSYy------- 151 thale cress
AAB67881  57 VAIAVAHAFALFVGVSMAAN--ISGGHLNPAVTLGLAVGGNITTLTGLFYWVAQLLGSTVACLLLKYVTNGL-------- 126
P25818    59 VAAAVAHAFGLFVAVSVGAN--ISGGHVNPAVTFGAFIGGNITLLRGILYWIAQLLGSVVACLILKFATGG--------- 127 thale cress
P26587    67 ILVALAHAFALFAAVSAAIN--VSGGHVNPAVTFGALVGGRVTAIRAIYYWIAQLLGAILACLLLRLTTNG--------- 135 thale cress
P08995    71 PGIAIVWGLVLTVLVYTVGH--ISGGHFNPAVTIAFASTRRFPLIQVPAYVVAQLLGSILASGTLRLLFMG--------- 139 soybean
1LDI_A    43 EISVI-WGLGVAMAIYLTAG--VSGAHLNPAVTIALWLFACFDKRKVIPFIVSQVAGAFCAAALVYGLYYNLffdfeqth 119 Escherichia coli
6POJ_A   120 ----------TGNSLGRNDLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLgGS----APLAIGLSVALGHLLAID 185 human
P23645   171 ----------QGNLQAAISHSAALAAWERFGVEFILTFLVVLCYFVSTDPMKKFM-GN----SAASIGCAYSACCFVSMP 235 fruit fly
P23900   402 ----dwwmneSVAGMFCVFPKPYLSSGRQFFSEFLCGAMLQAGTFALTDPYTCLS-SDv---FPLMMFILIFIINASMAY 473 Saccharomyces cerev...
2C32_A   112 ----------VRGNLALNTLHPGVSVGQATIVEIFLTLQFVLCIFATYDERRNGRlGS----VALAVGFSLTLGHLFGMY 177 cattle
6QF5_B   112 ----------IRGDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENpGT----PALSIGFSVALGHLLGIH 177 human
Q08451   160 ----------QRLGGGANVVNPGYTKGDGLGAEIIGTFVLVYTVFSATDAKRNARdSHvpilAPLPIGFAVFLVHLATIP 229 tomato
P43286   152 ----------TRYGGGANSLADGYSTGTGLAAEIIGTFVLVYTVFSATDPKRSARdSHvpvlAPLPIGFAVFMVHLATIP 221 thale cress
AAB67881 127 -----------AVPTHG--VAAGMNGAEGVVMEIVITFALVYTVYATAADPKKGSlGTi---APIAIGFIVGANILAAGP 190
P25818   128 ----------LAVPAFG--LSAGVGVLNAFVFEIVMTFGLVYTVYATAIDPKNGSlGTi---APIAIGFIVGANILAGGA 192 thale cress
P26587   136 ----------MRPVGFR--LASGVGAVNGLVLEIILTFGLVYVVYSTLIDPKRGSlGIi---APLAIGLIVGANILVGGP 200 thale cress
P08995   140 -----------NHDQFSGTVPNGTN-LQAFVFEFIMTFFLMFVICGVATDNRAVGe-----fAGIAIGSTLLLNVIIGGP 202 soybean
1LDI_A   120 hivrgsvesvDLAGTFSTYPNPHINFVQAFAVEMVITAILMGLILALTDDGNGVPrGPl---APLLIGLLIAVIGASMGP 196 Escherichia coli
6POJ_A   186 YtgcgINPARSFGSAVITHN-------------FSNHWIFWVGPFIGGALAVLIY 227 human
P23645   236 Y----LNPARSLGPSFVLNK-------------WDSHWVYWFGPLVGGMASGLVY 273 fruit fly
P23900   474 QtgtaMNLARDLGPRLALYAvgfdhk-mlwvhhHHFFWVPMVGPFIGALMGGLVY 527 Saccharomyces cerevisiae S288C
2C32_A   178 YtgagMNPARSFAPAILTRN-------------FTNHWVYWVGPVIGAGLGSLLY 219 cattle
6QF5_B   178 YtgcsMNPARSLAPAVVTGK-------------FDDHWVFWIGPLVGAILGSLLY 219 human
Q08451   230 ItgtgINPARSLGAAIIYNDeh----------aWNDHWIFWVGPMIGAALAAIYH 274 tomato
P43286   222 ItgtgINPARSFGAAVIYNKsk----------pWDDHWIFWVGPFIGAAIAAFYH 266 thale cress
AAB67881 191 FsggsMNPARSFGPAVVAGD-------------FSQNWIYWVGPLIGGGLAGFIY 232
P25818   193 FsgasMNPAVAFGPAVVSWT-------------WTNHWVYWAGPLVGGGIAGLIY 234 thale cress
P26587   201 FsgasMNPARAFGPALVGWR-------------WHDHWIYWVGPFIGSALAALIY 242 thale cress
P08995   203 VtgasMNPARSLGPAFVHGE-------------YEGIWIYLLAPVVGAIAGAWVY 244 soybean
1LDI_A   197 LtgfaMNPARDFGPKVFAWLagwgnvaftggrdIPYFLVPLFGPIVGAIVGAFAY 251 Escherichia coli
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