1ZKZ,4MPL


Conserved Protein Domain Family
TGF_beta_BMP9
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cd19400: TGF_beta_BMP9 
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 9 (BMP-9) and similar proteins
BMP-9, also termed growth/differentiation factor 2 (GDF-2), is a potent circulating inhibitor of angiogenesis. It signals through the type I activin receptor ACVRL1 but not other activin receptor-like kinases (ALKs).
Links
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Statistics
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PSSM-Id: 381670
Aligned: 7 rows
Threshold Bit Score: 207.042
Created: 19-Jul-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
putative
Conserved site includes 28 residues -Click on image for an interactive view with Cn3D
Feature 1:putative homodimer interface [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens BMP-3 (2QCQ) forms a homodimer.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               # #   ## #         # ###                ##  ## ##  #   ###  # ##  #      
1ZKZ_A         6 SHCQKTSLRVNFeDIGWDSWIIAPKEYEAYECKGGCFFPLaDDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVL 85  human
4MPL_A        12 SHCQKTSLRVNFeDIGWDSWIIAPKEYEAYECKGGCFFPLaDDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVL 91  human
Q9UK05       325 SHCQKTSLRVNFeDIGWDSWIIAPKEYEAYECKGGCFFPLaDDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVL 404 human
P34822       323 NHCRRTSLHVNFkEIGWDSWIIAPKDYEAFECKGGCFFPLtDNVTPTKHAIVQTLVHLQNPKKASKACCVPTKLDAISIL 402 chicken
XP_005992508 297 NHCRKASLRVDFkEIGWDSWIVAPKQYDAFECKGVCYFPLtDNVTPTKHAIIQSLVHLKNPKKAAKACCVPTKLDSISVL 376 coelacanth
F1QWZ4       286 NYCRRTSLKVNFkDIGWDKWIVAPPEYDAYECKGVCYFPLtDDVSPSRHAVIQTLVNLSNPKKANMACCVPTKLDPIAVM 365 zebrafish
XP_018082173 305 NYCRKSSLKVNFkDIGWDSWIISPTEYDAYECKGECYYPLtDNLTPTKHAIIQTLMHFKNPKVTKKACCVPTQLEPISIF 384 African clawed ...

Feature 1                      ### #     #
1ZKZ_A        86 YKDDmGVPTLKYHYEGMSVAECGCR 110 human
4MPL_A        92 YKDDmGVPTLKYHYEGMSVAECGCR 116 human
Q9UK05       405 YKDDmGVPTLKYHYEGMSVAECGCR 429 human
P34822       403 YKDDaGVPTLIYNYEGMKVAECGCR 427 chicken
XP_005992508 377 YKDDaGVLTLKYKYEGMKVAECGCR 401 coelacanth
F1QWZ4       366 YQEK-GVITVRHLYEEMKVAKCGCR 389 zebrafish
XP_018082173 385 YIDDkGVPTMKYKYEGMKVAKCGCR 409 African clawed frog

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