Conserved Protein Domain Family
bHLH-PAS_NCoA1_SRC1
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cd18948: bHLH-PAS_NCoA1_SRC1 
basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 1 (NCoA-1) and similar proteins
NCoA-1, also termed Class E basic helix-loop-helix protein 74 (bHLHe74), or protein Hin-2, or RIP160, or renal carcinoma antigen NY-REN-52, or steroid receptor coactivator 1 (SRC-1), is a bHLH-PAS nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion.
Links
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Statistics
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PSSM-Id: 381518
Aligned: 6 rows
Threshold Bit Score: 106.98
Created: 11-Jan-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus NPAS3 (5SY7)-ARNT complex binds HRE DNA.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         ###   # ##   #                        ##                     
Q15788         27 LASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEK 87   human
NP_001012900   26 TAQSNEKRRREQENKYLEELAELLSANIGDIDTLSVKPDKCKILKKTVDQIQQMKRLEQEK 86   chicken
AAY85299       27 SGPSVEKRRRELECRYIDELAELLSANMSDIASLNVKPDKCHILKSTVDQIQQIKRREQEN 87   zebrafish
OCT79126       25 TAQSTEKRRREQENKYLEELAELLSANIGDIDSLSVKPDKCKILIKRMDQIQQLKKKKQEK 85   African clawed frog
XP_014341047   27 LGQSMEKRRREQENRYIEELAELLSANIGDIDSLSVKPDKCRILKKTVDQIQQIKRLGQGK 87   coelacanth
XP_014793433   59 FFNSNEKRRREQENKYLEELAELLSANIGDIDTLSVKPDKCKILKKTVDQIQQMKRLEQEK 119  Philomachus pugnax

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