2YPA


Conserved Protein Domain Family
bHLH_E-protein_E47-like
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cd18943: bHLH_E-protein_E47-like 
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basic helix-loop-helix (bHLH) domain found in transcription factor E47 and similar proteins
E47 is a class I bHLH transcriptional regulator that forms heterodimers with class II bHLH proteins to regulate distinct differentiation pathways. Its homodimers regulate B lymphocytes development.
Links
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Statistics
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PSSM-Id: 381513
Aligned: 4 rows
Threshold Bit Score: 106.669
Created: 11-Jan-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Structure:2YPA; Homo sapiens E47-TAL1 complex binds DNA, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  #   # ### #    #                    ##                          
2YPA_B         7 EEKDLRDRERRMANNARERVRVRDINEAFRELGRMCQMHLKSDKAQTKLLILQQAVQVILGLEQQVRERNLNPK 80  human
CAE30454     552 EDKDLRDRERRMANNARERVRVRDINEAFKELGRMCQMHLKTDKAQTKLIILQQAVQVILGLEQQVRERNLNPK 625 chicken
NP_001093743 544 EEKDSRDRDRRMSNNARERVRVRDINEAFKELGRMVQMHMKADKAQTKLIILQQAVQVIMTLEQQVRERNLNPK 617 western clawed frog
AAI00123     401 EEKEQRERERRMANNARERVRVRDINEAFRELGRMCQLHLRSDKAQTKLIILQQAVQVILSLERQVRERNLNPK 474 zebrafish

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