4H10,4F3L


Conserved Protein Domain Family
bHLH-PAS_ARNTL_PASD3
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cd11438: bHLH-PAS_ARNTL_PASD3 
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basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
ARNTL, also termed Basic-helix-loop-helix-PAS protein MOP3, or brain and muscle ARNT-like 1 (BMAL1), or Class E basic helix-loop-helix protein 5 (bHLHe5), or member of PAS protein 3, or PAS domain-containing protein 3 (PASD3), or bHLH-PAS protein JAP3, is a member of the bHLH-PAS transcription factor family that forms heterodimers with another bHLH-PAS protein, CLOCK (circadian locomotor output cycle kaput), which regulates circadian rhythm. ARNTL-CLOCK heterodimer complex activates transcription from E-box (CANNTG) elements found in the promoter of circadian responsive genes. ARNTL is highly homologous to ARNT.
Links
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Statistics
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PSSM-Id: 381444
Aligned: 8 rows
Threshold Bit Score: 116.747
Created: 2-Aug-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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DNA bindingdimer interface
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Structure:4H10; Homo sapiens CLOCK-BMAL1 basic helix-loop-helix domains bind E-box DNA, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               #  ## ### ##   #                    ##                   
4H10_A         3 QGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGAWL 66  human
Q9I8T7        74 QGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATN 137 chicken
NP_001089024  72 EGRLRNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATN 135 African clawed frog
AAI34896      92 DQQMKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGAAN 155 zebrafish
4F3L_B         7 QGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATN 70  house mouse
O00327        67 QGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATN 130 human
XP_007886006  79 HGRVKNAREAHSQIEKRRRDKMNSFIDELASMVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATN 142 elephant shark
XP_014348974  74 QGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCSAMSRKLDKLTVLRMAVQHMKTLRGATN 137 coelacanth

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