Conserved Protein Domain Family
SET_EZH1
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cd19217: SET_EZH1 
SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins
EZH1 (EC 2.1.1.43), also termed ENX-2, or histone-lysine N-methyltransferase EZH1, is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.
Links
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Statistics
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PSSM-Id: 380994
Aligned: 5 rows
Threshold Bit Score: 275.022
Created: 12-Jun-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens polycomb repressive complex 2 (PRC2) binds H3k27m peptide and S-adenosyl-L-homocysteine.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                      # ##                #      #  ##  #   #  # #####                ##
Q92800       608 QRGLKKHLLLAPSDVAGWGTFIKEsVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVVDATRKGNKIRF 687 human
NP_001035072 617 QRGLKKHLLLAPSDVAGWGTFIKEpVQKNEFISEYCGELISQDEADRRGRIYDKYMSSFLFNLNNDFVVDATRKGNKIRF 696 Danio rerio
KGL85803     602 QRGLKKHLLLAPSDVAGWGTFIKEsVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVVDATRKGNKIRF 681 Charadrius voci...
CDQ85039     114 QRGLKKHLLLAPSNVAGWGTFIKEsVQKNEFISEYCGELISQDEADRRGRIYDKYMSSFLFNLNNDFVVDATRKGNKIRF 193 rainbow trout
XP_014342734 564 QRGLKKHLLLAPSDVAGWGTFIKDsVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVVDATRKGNKIRF 643 coelacanth

Feature 1        ###       #                          # ##               
Q92800       688 ANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQaGEELFFDYRYSQADALKYVGIERE 743 human
NP_001035072 697 ANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQqGEELFFDYRYSQADALKYVGIERE 752 Danio rerio
KGL85803     682 ANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQaGEELFFDYRYSQADALKYVGIERE 737 Charadrius vociferus
CDQ85039     194 ANHSVNPNCYAKVVMVNGDHRIGIFAKRAILqGEELFFDYRYSQDDALKYVGIERE 249 rainbow trout
XP_014342734 644 ANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQkGEELFFDYRYSQADALKYVGIERQ 699 coelacanth

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