Conserved Protein Domain Family
SET_SETDB1
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cd10517: SET_SETDB1 
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins
SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.
Links
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Statistics
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PSSM-Id: 380915
Aligned: 20 rows
Threshold Bit Score: 364.303
Created: 6-Jan-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens EHMT1 (3HNA) binds SAH and mono-methylated H3k9 peptide.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
Q15047        674 KPFYYIl-DITYGKedvp---lscvNEIDTTPPpqvaYSKERipgkgvf---intgpeFLVGCDCkdGCrdksKCaCHQl 746  human
CBY08445      769 KLKGFIceDFSEGKenrp---ipmyNQVDNDRPpemiYYVRPilhasar---inmekeFLLSCNCtdGCr--rNCpCNLq 840  Oikopleura di...
Q28Z18        885 ESTIVKeaDISKGQekma---iplvNYYDNTLPppceYAKQRiptegvn---lnldeeFLVCCDCedDCsdkeSCaCWQl 958  Drosophila ps...
ELU15418      610 KTFCDIk-DLSYGRetvp---iscvNGIDRQYPdyveYSNQRipakgvn---lnldpeFLVGCDCtdGCrdpsKCaCIQm 682  Capitella teleta
XP_013401598  643 VPLKTFc-DIKDLSygketvpiscvNGIDRQYPeyveYSNQRlpargvk---lnldpdFLSGCDCtdGCrdhtKCsCRQl 718  Lingula anatina
EEC01716      385 EPQTVLs-SLKDLTygke---lvpvTCINSLSTeypsYIEYSatrypgkgvtlnldkeFLCGCDCedDCqdrdKCsCQQl 460  black-legged ...
EFX64878      696 VVYSKIn-DITYGKenvr---vscvNSIDRSNPeyveYSTERiprqgvn---lnldpnFLVCCDCtdDCqdkeKCqCWQl 768  common water ...
CCD79402      647 KTLTNIv-DLSYGKenvp---ipcvNSVDNEVPgyidYTPQRqpignvp---llkdskFLVCCDCtdNCrdrtKCaCQQl 719  Schistosoma m...
EDV19880      486 HFAVESi-TISNNSfvpgk--cmneSDITQVSEsf-tYIADSicidgle---ipsdpdFMVCCNCkdNCldktKCeCQRl 558  Trichoplax ad...
NP_498848     916 DKYLKVa-DFSLGTegip---iplvNSVDNDEPpsleYSKRRfqyndqvd-issvsrdFCSGCSCdgDCsdasKCeCQQl 990  Caenorhabditi...

Feature 1                                                                                   ###   
Q15047        747 tiqatact-----pggqinpnSGYQYKrleeclpTGVYECNKRCKCdp---nMCTNRLVQHGLQVRLQLFKTqnKGWGIR 818  human
CBY08445      841 taegaq---------kldacyRNYIYGrlvdiiaTGIFECNSNCKCkncidkPCQNSIVQRGLRQDLQLFKTfkKGWGVR 911  Oikopleura di...
Q28Z18        959 tvtgvryc-----npkkpieeIGYQYKrlhegvlTGIYECNSRCKCk----kNCLNRVVQHSLEMKLQVFKTsnRGWGLR 1029 Drosophila ps...
ELU15418      683 tleaskglhg-krsmvtnpdfTGYEHRrlmepviTGVYECNSRCKCd----hRCSNRVVQNGLSLRLQVFKTekRGWGLR 757  Capitella teleta
XP_013401598  719 tiqaaeai-----pnqmvdgiPGYQHRrlvdslrTGIFECNSRCKCd----cRCVNRVAQNGQQLRLQVFKTekRGWGLR 789  Lingula anatina
EEC01716      461 tvaatga------lpsgvnpsAGYRFRrlhepliTGVYECNAQCKCs----kRCQNRVVQNGLRCRLQVFRTekRGWGVR 530  black-legged ...
EFX64878      769 tikatalg-----psgkidptAGYHYRrlmqnvvTGVYECNSRCSCr----kTCINRVAQRPLHLRLQLFRTerRGWGIR 839  common water ...
CCD79402      720 tveasslt----npnglvdsqAGYRYRrlsqftvGGVYECNSNCQCd----rRCSNRVVQQGLWVRLQVFKTarKGWGIR 791  Schistosoma m...
EDV19880      559 tytsnaa------vfgrsthsVGYELKrlaarvlTGIYECNPRCTCkrnkagQCYNSVVQNGIQHRLQVFMTtkKGWGVR 632  Trichoplax ad...
NP_498848     991 sieamkrlphnlqfdghdelvPHYQNRllsskviSGLYECNDQCSChr---kSCYNRVVQNNIKYPMHIFKTaqSGWGVR 1067 Caenorhabditi...

Feature 1                      #      #  ## #     ######  #                                       
Q15047        819 CLDDIAKGSFVCIYAGKILtDDFADKEGLEmGDEYFANLDHIESVENFKEGYESDApcssdssgvdlkdqedgnsgtedp 898  human
CBY08445      912 TMSDIPFGAFICIYAGIVRsEDEAERHGRKlGDEYFANLDYIESGERTKWDVNRNKdsgkesedsedekepesdeekfek 991  Oikopleura di...
Q28Z18       1030 CVNDIPKGAFVCIYAGHLLtEAKANEGGQDaGDEYFADLDYIEVAEQLKEGYESDVeradldheddnygpdaeddddfrp 1109 Drosophila ps...
ELU15418      758 CLDDIPKGGFICIYAGQLLtEQGANEDGQQyGDEYLAELDYIEVVEHLKEGYESDVveeeemqeeeeeeeeeeeeevrek 837  Capitella teleta
XP_013401598  790 CLDDIPEGGFVCIYAGQLLtEQGANEDGHNyGDEYLAELDYLDVVEQMKEGYEADVvdpdadegvgeeveeeeeeeeede 869  Lingula anatina
EEC01716      531 CLDDLPQGCFVCIYAGQLLtEQGANEDGNQyGDEYLAELDHIEVVEKQKEGYESDVvnseeeeegdeeaavsdydddsve 610  black-legged ...
EFX64878      840 CLDDIPKGQFICVYAGQLLtEQEANEDGKQfGDEYLAELDLIESIEQAKDGYESDVdididhqsdisqssssddsgefsd 919  common water ...
CCD79402      792 ALNAIPKGTFICTYAGAIYdEAMAVQEGFDcGDEYQAELDYIETVEKDKEGYESTVedlneilnettvaliqrsaslepe 871  Schistosoma m...
EDV19880      633 TLDDIPKGAFVSMYAGVVItEQEAQRRGVKhDDQYYAELDLIEMIIGSQEAKKSKDcrsskeennkksnknktsskedle 712  Trichoplax ad...
NP_498848    1068 ALTDIPQSTFICTYVGAIL-TDDLADELRN-ADQYFADLDLKDTVELEKGREDHETdfgyggdesdyddeegsdgdsgdd 1145 Caenorhabditi...

Feature 1                                                                                         
Q15047        899 eesnddssddnfckdedfstssvwrsyatrrqtrgqkenglsettskdshppdlgpphipvppsipvggcnppsseetpk 978  human
CBY08445      992 kdgeqafapashhfinpsqdgqlrrssrkrkkkvskk------------------------------------------- 1028 Oikopleura di...
Q28Z18       1110 nnyyqkkkeklrssrsn--------------------------------------------------------------- 1126 Drosophila ps...
ELU15418      838 epqlddsdssysagasslrkslepvklvlkrnqkderkkswsvhtkksdsrkrtegwlrq-------------------- 897  Capitella teleta
XP_013401598  870 ddeggdsdstysgekyigkedssesgapftlrqrstrrreadrsrsgerrdeniklvirrdsaekgqewsvkpakeksdp 949  Lingula anatina
EEC01716      611 ksqrtpkkkek--------------------------------------------------------------------- 621  black-legged ...
EFX64878      920 iseskslmpgnen------------------------------------------------------------------- 932  common water ...
CCD79402      872 ikdrkplerskshrkdsekqhrrqh------------------------------------------------------- 896  Schistosoma m...
EDV19880      713 ncsdnlsdqynrsysekdatsncfedvvs--------------------------------------------------- 741  Trichoplax ad...
NP_498848    1146 vmnkmvkrqdssesgeetkrltr--------------------------------------------------------- 1168 Caenorhabditi...

Feature 1                                                                                         
Q15047        979 nkvaswlscnsvseggfadsdshssfktneggegraggsrmeaekastsglgikdegdikqakkedtddrnkmsvvtess 1058 human
CBY08445          --------------------------------------------------------------------------------      Oikopleura di...
Q28Z18            --------------------------------------------------------------------------------      Drosophila ps...
ELU15418          --------------------------------------------------------------------------------      Capitella teleta
XP_013401598  950 ikektaewvrklpesqprdeddvvvldsdddde----------------------------------------------- 982  Lingula anatina
EEC01716          --------------------------------------------------------------------------------      black-legged ...
EFX64878          --------------------------------------------------------------------------------      common water ...
CCD79402          --------------------------------------------------------------------------------      Schistosoma m...
EDV19880          --------------------------------------------------------------------------------      Trichoplax ad...
NP_498848         --------------------------------------------------------------------------------      Caenorhabditi...

Feature 1                                                                                         
Q15047       1059 rnygynpspvkpeglrrppsktsmhqsrrlmasaqsnpddvltlssstesegesgtsrkptagqtsatavdsddiqtiss 1138 human
CBY08445          --------------------------------------------------------------------------------      Oikopleura di...
Q28Z18            --------------------------------------------------------------------------------      Drosophila ps...
ELU15418      898 --------------------------------------------------------------ipdsaiiisdegdnsqgs 915  Capitella teleta
XP_013401598  983 --------rgegssqsdelpdlepsstpvlgrkiggdsshgksserpknssgkkirmredspiatdvtdwddteeeqpak 1054 Lingula anatina
EEC01716          --------------------------------------------------------------------------------      black-legged ...
EFX64878          --------------------------------------------------------------------------------      common water ...
CCD79402          --------------------------------------------------------------------------------      Schistosoma m...
EDV19880          --------------------------------------------------------------------------------      Trichoplax ad...
NP_498848         --------------------------------------------------------------------------------      Caenorhabditi...

Feature 1                                                                               #         
Q15047       1139 gsegddfedkknmtgpmkrqvavkstrgfalksthgiaikstnmasvdkgesapvrkntrqfydgEESCYIIDAKLeGNL 1218 human
CBY08445     1029 -----aarnkstsrkekksekddklekedekpekqddfsdseeewsrtreffqteeelqpqedrgKRIMYVIDAKHqGNF 1103 Oikopleura di...
Q28Z18       1127 -------------------------ssstqnteldsqertvisfnpntdldetvrensvrrffgkDQTPFIMDAKTtGNL 1181 Drosophila ps...
ELU15418      916 dkstkvkadatdseknsdskgkniraarsttasrfsalpnpktcaqdqqqqkeeedpassrilfgEEACFVMDAKSmGNL 995  Capitella teleta
XP_013401598 1055 qfntarkktaaasrfknlpdpkaqdavaplkiklskmdlsrtektdeedakkdkpkfpsirsffnEEFCYVMDAKSiGNI 1134 Lingula anatina
EEC01716      622 ------------------------------nkagkgdgkvktgplespgiggkrlrfpptrsffnEEYCYIMDAKNcGNI 671  black-legged ...
EFX64878      933 ----------------------------kndscseklsahtlsstavriiqkddcqkktrelygpNEHCYVMDAKStGNI 984  common water ...
CCD79402      897 -----------------hhhhhhhrnhrqqqlqqlsqshqqnqqqtkrmypvaqkdwlrartyfnDINPYIMDAKKmGNL 959  Schistosoma m...
EDV19880      742 -------------tseenrqnsieyyhdslseklfdvevsddedrttigktveiegeefrqlhggSSEPFIVDSKRiGNI 808  Trichoplax ad...
NP_498848    1169 -------------------qkrkqskksgkggsvekddttprdsmekdnieskdepvfnwdkyfePFPLYVIDAKQrGNL 1229 Caenorhabditi...

Feature 1          #####       # #            #               # #           #####          
Q15047       1219 GRYLNHSCsPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDYNYEVGSVeGKELLCCCGAIECRGRLL 1291 human
CBY08445     1104 GRYLNHSCaPNLDTQNVIINTADLRMPTVAFFARRNIKAGEELCWDYQYSLDPDpEKGLKCFCGTSACRGRLR 1176 Oikopleura dioica
Q28Z18       1182 GRYFNHSCsPNLFVQNVFVDTHDLRFPWVGFFASSHIRSGTELTWNYNYEVGVVpNKVLYCQCGAQNCRVRLL 1254 Drosophila pseudoobs...
ELU15418      996 GRYLNHSCsPNAYVQNVFVDTHDMRFPWVAFFAYQFIRAGTELTWDYNYEVGSVpGKSLYCYCGSAECRGRLL 1068 Capitella teleta
XP_013401598 1135 GRYMNHSCmPNMFVQNVFVDTHDLRFPWVAYFSSQYIRAGTELTWDYNYEVGSVpGKILYCYCGSADCRGRLL 1207 Lingula anatina
EEC01716      672 GRYLNHSCcPNVYVQNVFVDSHDLRFPWVAFFASRYIRAGMELTWDYNYDVGSVpERVMYCQCGAEECRGRLI 744  black-legged tick
EFX64878      985 GRYLNHCCkPNVFVQNIFVDTQDLRFPWVGFFAHVFIRAGTELTWDYSYQVDSVpDKKLFCHCGAKECRGRLL 1057 common water flea
CCD79402      960 GRYFNHSCnPNVFVQNVFIDTHDPRFPEVAFFAKRNIDVGEEMTWDYGYTVDAVpFKVLYCYCGEPNCRIRLL 1032 Schistosoma mansoni
EDV19880      809 GRFYNHSCdPNMFVQNVFWKTQDLRFPTLSFFTLRSIPAGSELTWDYGYEMGSVeGKVKYCFCGASNCRKRLY 881  Trichoplax adhaerens
NP_498848    1230 GRFLNHSCdPNVHVQHVMYDTHDLRLPWVAFFTRKYVKAGDELTWDYQYTQDQTaTTQLTCHCGAENCTGRLL 1302 Caenorhabditis elegans

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