2XPY


Conserved Protein Domain Family
Leuk-A4-hydro_C
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pfam09127: Leuk-A4-hydro_C (this model, PSSM-Id:378127 is obsolete and has been replaced by 462686)
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Leukotriene A4 hydrolase, C-terminal
Members of this family adopt a structure consisting of two layers of parallel alpha-helices, five in the inner layer and four in the outer, arranged in an antiparallel manner, with perpendicular loops containing short helical segments on top. They are required for the formation of a deep cleft harbouring the catalytic Zn2+ site in Leukotriene A4 hydrolase.
Links
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Statistics
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PSSM-Id: 378127
Aligned: 235 rows
Threshold Bit Score: 74.8338
Created: 3-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2XPY_A        506 FNSNQLVLFLET-LTQnghsnKKPKDfdwakfPVASRALLDIYqdNIVKSQNA-EVVFKMFKFQIFAKL--QEEY-KHLA 580 baker's yeast
35_pfamImport   1 WEARPMLYFLDCfLETk----FS--S------AEVVIVLGDTL--ALWGSRNS-EILFRWALILVKNVV--ISKL-SVVR 62 
A0CV66        530 FKSNQKQLFLSS-LTEk----SKDIT------EAIMVSLEDAY--HLSDLRDA-ELLFRWYALSINTKYakDTTNlQKIK 595 Paramecium tet...
A0E332        531 FKSNQKQLFLSY-MQEk----YVNLN------SITMKQLDLSY--NLSENKDA-ELLFRWYTLSIQTKYatTNTNlNKIR 596 Paramecium tet...
Q22HJ7        532 FSLNEKCIFLQY-LFDh----TSEYD------SQVLIKIDQDY--NLTNSSNQ-EISWRWFRTTIMVGY--NSVQ-DKIE 594 Tetrahymena th...
EGR30941      551 YDLNTKSIFLQS-LFEn----LSKIN------VDILKRIEEDY--QLSTQQNK-ELLWRWYRITILAGY--NDNK-ELVH 613 Ichthyophthiri...
A0E1S0        522 YKPNQKSVFLQY-LIDn----YKDVE------AAVMTKMDEQY--KLTFYKDQ-KTVYKWYRLVLLVKY--DQAL-EGVH 584 Paramecium tet...
A0C1B0        526 YIYYQKQQFLNE-IATk----YVEMT------DKNYKLMDQTY--QLSDLKDS-RLLYRWLIGCLRGKF--YDRM-EVIK 588 Paramecium tet...
A0CGV7        510 YMPNQKMIFMQQ-ILDn----YTKLN------HQRLKELDDYY--KLSGTKSGpKIAFKWYKTVILSKY--DPGL-EAVH 573 Paramecium tet...
A0DB96        520 YMPNQQTIFMQQ-IMSn----WEKLT------NSKIKALDDFY--KFSGAKQGvQIGFKWYRTIVLCKY--EDSF-WAVR 583 Paramecium tet...

2XPY_A        581 DWLGTVGRMKFVRPGYRLLNSv----dRRLALATFDKFKDTYHPICKALVKQDL 630 baker's yeast
35_pfamImport  63 RFLEMQGKQKFQLPIYRLLTSslnddvRKFGSDTYAATKNMLHVMVRARVE--- 113
A0CV66        596 AFVGVVGRMKMVNPIYKALNK-------ETATQWYQENYAFYHPLTRQSIESIi 642 Paramecium tetraurelia
A0E332        597 TFVGKIGRMKMINPIYKALDK-------NTAQTWYNENKNFYHPLARQSIENIi 643 Paramecium tetraurelia
Q22HJ7        595 QFLGLTGRIKMIKPVYQAFVQtg---qKQIAQNYLVQYQDFYHPLAVQAINRVi 645 Tetrahymena thermophila SB210
EGR30941      614 KFLGSIGRLKMITPVYLALIQng---qKELAKQYFVEYKNFYHPIAVSNIQKLL 664 Ichthyophthirius multifiliis
A0E1S0        585 DFVSKVGVSSYLKVLYDLLGQny----nKQAYDWFDENKSFYHPVVVQAIEKIL 634 Paramecium tetraurelia
A0C1B0        589 HFMGNHGARSWLVNMYGTLFKdk----pDVAREWFAEYRSFYHPSVVDALEnev 638 Paramecium tetraurelia
A0CGV7        574 GFLQSLGVRSYVVGTYEVLIPny----pNEADAWFAQDKWSYHPLVANRVEDML 623 Paramecium tetraurelia
A0DB96        584 QFLQSIGVRSYIVGIYEVLIQny----lNLAKQWFEEDKYLYHPLVSNKVQDML 633 Paramecium tetraurelia
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