3O73,1QRD,3F2V,3W78,2B3D,3U7I,3LT5,3HA2


Conserved Protein Domain Family
Flavodoxin_2
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pfam02525: Flavodoxin_2 (this model, PSSM-Id:376808 is obsolete and has been replaced by 426816)
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Flavodoxin-like fold
This family consists of a domain with a flavodoxin-like fold. The family includes bacterial and eukaryotic NAD(P)H dehydrogenase (quinone) EC:1.6.99.2. These enzymes catalyze the NAD(P)H-dependent two-electron reductions of quinones and protect cells against damage by free radicals and reactive oxygen species. This enzyme uses a FAD co-factor. The equation for this reaction is:- NAD(P)H + acceptor <=> NAD(P)(+) + reduced acceptor. This enzyme is also involved in the bioactivation of prodrugs used in chemotherapy. The family also includes acyl carrier protein phosphodiesterase EC:3.1.4.14. This enzyme converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine residue from ACP. This family is related to pfam03358 and pfam00258.
Links
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Statistics
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PSSM-Id: 376808
Aligned: 252 rows
Threshold Bit Score: 52.3325
Created: 30-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3O73_A          4 KKVLIVYAHQEP-KSFNGSLKNVAVDELSRQg-----cTVTV-SDLYAMnF--EPRATDKDIT-GtLSNPEvfnygveth 73  human
CCO64390        2 AKIVAIIGDPRE-KGTSRDLFQKYLAVFQEQpt----iEVKI-YDIRKLaF--DPNLPE--------GYRTe-------- 57  Listeria monoc...
Q92AL9          2 AKVVAIMGDPREk-GTSRELFHKYLTFFQGHsa----ieIKT-YDIRELaF--DPNLPE--------GYRTeq------- 58  Listeria innocua
Q97HK9          1 MKVTVLNGSPK---EACNTVTMKYVEFLEKSfakhsftYINItRNIRRL------------------ENDEk-------- 51  Clostridium ac...
jgi:Mboo_2182   1 MKIVVLNGSP----KGDISVTMQYVAYLKKKfpehsfeTVNVaHEIEKI------------------EKDSv-------- 50  Methanoregula ...
Q72BJ7          2 KKILAINGSYREg-GVTDQILDHFEYAANTFdm-----qIET-AVLRNLhIefCTNCRR--------CTQEag------- 59  Desulfovibrio ...
ABN07907        1 MKITVIYGTNRTeKSSTYNIARQFIEELADGd------tVTE-FHLPRD----MPVFCTGCLTcL-SDSTK--------- 59  Methanocorpusc...
ABN07897        1 MKITVIYGTSRTeKSSTYNIAQQFLAELADGd------pVTE-FHLPKD----MPEFCTGCFNcF-SDPAK--------- 59  Methanocorpusc...
Q5WD38          1 MKVMALFGSARI-EGNTEQLADIALRGINHRr-----------IHLLKCgF--DPIIDER-------HAPNgf------- 52  Bacillus claus...
Q7WAP8          8 NPVLVLVGSPRRd-GNSALLAQAVAEGARQSg------aVAT-LLFLDD-Y--IAGFLTd----E-KEAda--------- 62  Bordetella par...

3O73_A         74 eaykqrslA-SDI----TDEQ--KKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFdi------pGfy--dsGLL 138 human
CCO64390       58 --------QtPDI----IALK--NDVRSADLLLFSYPVWWFNVPAVLKGVIDHLFWPGESYsfk----dkKyf--ltGPW 117 Listeria monoc...
Q92AL9         59 -------tT--------EMTNlkQDASSADLLLFAYLVWWFNVPAVLKGVIDHLFWRGESYsfk-----------dkKYL 112 Listeria innocua
Q97HK9         52 -----------------ERHKiiDKIKEADVVIWGFPVYLGLVPAGYKRFIELIFENNMa-----------------EVF 97  Clostridium ac...
jgi:Mboo_2182  51 -----------------CFAAilDRIRSADLVLWAFPLYYLLVCAQYKRFIELVFERGAq-----------------DAF 96  Methanoregula ...
Q72BJ7         60 -------rKpGTCihedEMNTliQKIENADFYVFASPTNMYSSTALFRRFLERLVVYGYwpw------skNapefrkEGD 126 Desulfovibrio ...
ABN07907       60 --------CpHYK----YVQPieEAMESADLIIFTTPVYLLHVPGQVKALLDHF-----GFqwm----ahKp----kDVY 114 Methanocorpusc...
ABN07897       60 --------CpHYA----YIKPisDAMLNADLIIISAPVYVFHMPGQVKALLDHF-----GYqwi----ahRp----iEAF 114 Methanocorpusc...
Q5WD38         53 -------tAvNDG----YKEVl-DDFLNQDIVLFVTPLYWFGMSGQMKGFFDRWSQYMQ-----------DqrlgfhERI 109 Bacillus claus...
Q7WAP8         63 -------rRpDDR----YGELffDHFLPARAVVLCTPVYWYGMSAQAKAFFDR------SFtyysashprHae--vlRRM 123 Bordetella par...

3O73_A        139 Q-----GK-LALLSVTTGGTaEMYTktgVNGdS-RYFLWP-LqHGTLHFCGFKVL----APQI---SFa-P--EIAS-EE 199 human
CCO64390      118 R-----KK-RARLIYTIGGMeIQHR---LFA---RPALTA-L-RYPLWMSGVFSV----KVTS---IDr--------lDL 168 Listeria monoc...
Q92AL9        113 LtgpwrKK-RARLIYTIGGMeL-------QHrLfARPALTaL-RYPLWMSGVLSV----RAT-----------SIDRlDL 168 Listeria innocua
Q97HK9         98 R-----DKyAVIITTSVh--------------YfDIAAIKyV-HAIIDDLNMRYV----DYY-----------SAEIfDL 142 Clostridium ac...
jgi:Mboo_2182  97 A-----GKyAASLSTSIh--------------YaDMIAHDyI-HAVSDDLGMKYL----GAY-----------SAEMhDL 141 Methanoregula ...
Q72BJ7        127 A-----RK-KAILVSSCAAPgF-------MGrYfSDTLKS-L-KSAAKLVGADSV----GTLFvglV------GKERsPR 181 Desulfovibrio ...
ABN07907      115 F-----HK-QALVISTGARI------------GiRQTVRD-V-RNSLDWWGVGRIyrfkKTVG---MKgwRglSDKRkAA 171 Methanocorpusc...
ABN07897      115 F-----HK-QGLVITTAAGA------------GmRHAAKD-A-QDSFNWWGVGRTytfkKAVQ---ASewSqvSEKKrEK 171 Methanocorpusc...
Q5WD38        110 R-----GK-KAYVIVVGENPhPRIAa--------lPLIQQ-F-HAIFEYTGMEFS----DYII---GKgnR--PGTIkQD 164 Bacillus claus...
Q7WAP8        124 T-----GK-RLALAVSSEET--------YPGaAlGIVHQ--L-QEFTRYTHSQFV----GMVH---GAgnRrgEVAHdPR 179 Bordetella par...

3O73_A        200 ERKGMVAAWSQrL 212 human
CCO64390      169 SIRRTDDYYDKkV 181 Listeria monocytogenes serotype 4b str. LL195
Q92AL9        169 SIRKSNEYYDKkI 181 Listeria innocua
Q97HK9        143 TNEEKKNNFYSfG 155 Clostridium acetobutylicum
jgi:Mboo_2182 142 LDAGERERLVTfA 154 Methanoregula boonei 6A8
Q72BJ7        182 LSDKNIREIKSlA 194 Desulfovibrio vulgaris str. Hildenborough
ABN07907      172 FAQEIKQTSKKiR 184 Methanocorpusculum labreanum Z
ABN07897      172 ITKEVKATSRKiL 184 Methanocorpusculum labreanum Z
Q5WD38        165 QLALEKADFWNkT 177 Bacillus clausii KSM-K16
Q7WAP8        180 RPLQAAHRLGHgL 192 Bordetella parapertussis
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