4BPM,2H8A


Conserved Protein Domain Family
MAPEG
?
pfam01124: MAPEG (this model, PSSM-Id:376462 is obsolete and has been replaced by 460074)
Click on image for an interactive view with Cn3D
MAPEG family
This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism). It includes proteins such as Prostaglandin E synthase. This enzyme catalyzes the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.
Links
?
Statistics
?
PSSM-Id: 376462
Aligned: 189 rows
Threshold Bit Score: 33.8114
Created: 24-Apr-2019
Updated: 18-Jul-2019
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
4BPM_A         14 FLLCSTLLVIKMYVVAIITGQVRLrkkafanpedAlrhggpqYCrsdpDVERCLRAHRNDMETIYPFLFLGFVYSFLGPN 93  human
Q169W1         10 VLALAALLQVAQMCAYSVAANMQVda------ktAfgp-rdtPVqlsgVAARLQRAMNNHFEGLVLFSIAVGIVAISgqs 82  Roseobacter de...
jgi:Pden_0552   7 ALALAALLQAVQIGLAAALMNRDVga------nwNasp-rdrQPefsaLTGRLRRAVDNHFEGLILFTIAVVLVVLSdag 79  Paracoccus den...
Q1GLI7          7 ALAATVLIHVVTVIWSQRALEADIgr------dgNvgtrenlDErlseRSNRLRRALANHTENIGPFIIAVLLLTLTdna 80  Ruegeria sp. T...
Q21CX4         10 VLGWSVVLLIVQLFLASVPVTLELgg------ayQagprdqpRAakgvFAGRAARAFRNLLETYPAFVALALALSVTgrs 83  Rhodopseudomon...
Q2YLS4         14 liGWSVVLLVVHILLQSMMATQELgsrwn-agprDe-----sLKpsgrLAGRAERASANFRETYPAFIALALALVLKGDP 87  Brucella abort...
Q8P7G3          9 mLGWAMVLGLVQLLAASTSMTAQRgt------kwNasardgeTKpltgVAARLDRAFRNFLETFAIFAAAVLAVTVAGRT 82  Xanthomonas ca...
Q5NQE5          9 LLGIVLLLALLQIFLTAHFKTRQYgy------kwNvsardeaLPplspMAGRLSRAQANLFETLPLFIAALLANLYLghn 82  Zymomonas mobilis
jgi:Caul_2214   7 LLGVAVVIGLVHLLWAAAAAQPQRgl------kwNvgp-rdtPVtltgMAGRLERASANFRETFPFFAAAVLVAYLGgrl 79  Caulobacter sp...
Q9A7V1          9 MIAVAVAIGILNLLWASAAAQPQRgl------kwNvgp-rdeTIeltgMAGRLMRAFANFRETFPFFVALVIVDYLGgrl 81  Caulobacter vi...

4BPM_A         94 PFVAWMHFLVFLVGRVAHTVAYLGKlRAPIRSVTYTLAQLPCASMALQILW 144 human
Q169W1         83 TGFTAACAWVYLGARIAYVPAYAFG-LSPWRSIIWMIGIAATTALLIAGLI 132 Roseobacter denitrificans OCh 114
jgi:Pden_0552  80 SPLTVLCSWSYLLARLLYVPAYAYG-WSPWRSVIWGVGFIATLVMILTTLF 129 Paracoccus denitrificans PD1222
Q1GLI7         81 SSLTAICAWTYVAARALYVPAYAFA-WVPWRSVIYVIGLLATLLMIGASFF 130 Ruegeria sp. TM1040
Q21CX4         84 GGWGALGAEIWLAMRILYVPAYLIH-FPFARSLLWFASLLALLAMLARLLL 133 Rhodopseudomonas palustris BisB18
Q2YLS4         88 SGWGILGAWLWFFSRIVYIPLYLAG-IPYLRSFVWLISLVRLGIMLLALVl 137 Brucella abortus 2308
Q8P7G3         83 NAETALGVQLYLWARVAYVPVYALG-IPYLRSAIWVVSFWGIVKLVrallg 132 Xanthomonas campestris pv. campestris
Q5NQE5         83 GYYSELSAELYVASRLIYLPLYAFG-VPYLRSIVWAIGIIGLLGQILLIFC 132 Zymomonas mobilis
jgi:Caul_2214  80 GMLSAHGAVLYVGARAIYIFLYAFG-VPVVRSLVWLASLIGIGLILAALVI 129 Caulobacter sp. K31
Q9A7V1         82 GDLTVYGAALYVAARAAYLPLYAFG-VPYVRSLVWLASMVGILMLLAALVV 131 Caulobacter vibrioides
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap