1DEB


Conserved Protein Domain Family
APC_N_CC
?
pfam16689: APC_N_CC (this model, PSSM-Id:374728 is obsolete and has been replaced by 435517)
Click on image for an interactive view with Cn3D
Coiled-coil N-terminus of APC, dimerization domain
APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumor-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.
Links
?
Statistics
?
PSSM-Id: 374728
Aligned: 7 rows
Threshold Bit Score: 68.8033
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
1DEB_A          3 ASYDQLLKQVEALKMENSnLRQELEDNSNHLTKLETEASNMKEVLKQLQGSI 54  
1_pfamImport    1 AAYEQLVRQGEALPRTAT-WRQELRDNSSHLSKLETETSGMKAVLQHLQGKL 51  
XP_018668496   59 SRYDQLLQQVECLKLENTtLKKELSNNSSQISKLESEALNLKEMVVMLGNSI 110  vase tunicate
XP_010588123    4 ASYDQLLKQVEALKMENSnLRQELEDNSNHLTKLETEASNMKEVLKQLQGSI 55   African savanna elephant
XP_019201773    6 ASYDQLAHQVEALRKENShLRRELEDNSNHLSKLETETFGMKEVLKQLQSKL 57   Nile tilapia
OBS74820        6 ASYEQLVRQVEALKAENThLRQELRDNSSHLSKLETETSGMKEVLKHLQGKL 57   desert woodrat
XP_012810058   14 ASYDQLVRQVEDLKKENShLRRELKDNSSQLNRLEHDTSDMKEVLKhlqvkl 65   tropical clawed frog
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap