Conserved Protein Domain Family
SMG1

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pfam15785: SMG1 (this model, PSSM-Id:374109 is obsolete and has been replaced by 464869)
Serine/threonine-protein kinase smg-1
SMG1 is a family of eukaryotic proteins. In humans this family acts as an mRNA-surveillance protein. In C.elegans, SMG1, a phosphatidylinositol kinase-related protein kinase, is a key regulator of growth. Loss of SMG1 leads to hyperactive responses to injury and subsequent growth that continues out of control. It has an antagonistic role to mTOR signalling in these worms and possibly also in higher eukaryotes.
Statistics
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PSSM-Id: 374109
Aligned: 12 rows
Threshold Bit Score: 768.149
Created: 26-Apr-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EKC30990             623 MWALSPSIFDLASKHFSPLDEVVSEVYPAVQYALLNTLYSHCSRHGNFVSSSSLIMQTT------RLDGSLM-ANVNPTT 695  Pacifi...
XP_414907            630 MWALSPTVFALLSKNLMIVHGDIAVHFPAVQYAVLYTLYSHCSRHDHFISSSLSSSSPS------LFDGAVI-STVTTAT 702  chicken
EFZ20104             734 MWALKPSILELVAVKLKPYDNTLSMASPFLQYNVLYLLYAHCSRYNHFVPSSSLITGTTacrpmdMFPGTLD-VPATSPA 812  red fi...
XP_001947123         600 MWALQPSIFELLSTKL---DPTIIKMNDPLRFSLMFLLYSHCKKHNNFVASSRLVTAGR------TSEKSQQnVEINSHK 670  pea aphid
WGS:AAPP:GF21168-PB  557 MYACKPSILELLLTNCRAQDLALWSRYPSTHQAIINLLVVHCQANHNFRTNSSL-----------LRDQEQPlSENTSPT 625  Drosop...
Q29I80               480 MYACQPSILKLLISNCRAQDLCLWARYPTTHQALLGLLVVHCQANHNFRTNSIL-----------FRDPGLS-TENTSPT 547  Drosop...
WGS:AAQB:GK16214-PA  603 MYACKPSILELLIRNCRADDLALWSRYPGTYEAILNLLATHCQANHNFRTTSSL-----------LRDGNIQnPEHTSPT 671  Drosop...
EDX17288             581 MYACKPSILELLLTNCRAHELKLWGRYPAAQQAIFSLLVVHCQANHNFRTNSSL-----------LRDQELS-AENTSPT 648  Drosop...
XP_011604331         615 MWALSPTVFTLLSQNLLLVHSDLAVYYPTIQYAVLYTLYSHCTRHDHFISSSLS-SSPS------LFDGAVI-STVTTAT 686  torafugu
XP_016845620         747 MWALKPSILELLAVKLRPHDPLLSVESPLLQYHILFLLFTHCSRYNHFVPSSSLITGTSscrpldIFPGTLE-VPTVSPT 825  jewel ...
XP_023813689         626 MWALSPTVFALLTHNLTVVHSGLAVCYPAVQYAVLYSLYSHCTRHDHFISSSLSSSSPS------LFDGAVI-STVTTAT 698  Japane...
XP_009297729         622 MWALSPTVFALLSQNLVIVHSDLAVHHPAVQYAVLYTLYSHCTRHDHFISSSLSSSSPS------LFDGAVI-STVTTAT 694  zebrafish
EKC30990             696 ANNFTQILRLLAGLLSQV-HASYDSRCLGLKWIADII----GSLQTNPqIFYSEEFTNVIRYITQLGHNSDFQISMSVCR 770  Pacifi...
XP_414907            703 KKHFSIILNLLGLLLKKD-NLTQDTRKLLMTWALEVAvlmkKSETYAP-LFSLPSFHKFCKGLLANTLLEDVNICLQACS 780  chicken
EFZ20104             813 SGHLSIILNLIAKTYNK--NTPACTLLLLSTWLQEICv---QSEKYIGiLSETQECQSIISSLINCGATTNDDVANAACN 887  red fi...
XP_001947123         671 SGNLVKILNIFEKYLKR--NVNVDCKLLVLKWIYELlm-haDSASYLNiILLSPEMINIVRSLIYVALKRNEILLFDGIA 747  pea aphid
WGS:AAPP:GF21168-PB  626 ANNFATILRFLAAVLENAgLLNPQNLRQLLQWLQvl---lnECRDRCDlLLDQEQFLSICRSLVTTACKWS---PQESAA 699  Drosop...
Q29I80               548 AHSFEYIIRFLDSILTKAgRLAAENLKLLLQWTQll---ltECRERAPlLLEQDGFLGICYSVGGAAAKWR---PLESAA 621  Drosop...
WGS:AAQB:GK16214-PA  672 AQSFETIIGFLARNLEHSlQLTQQNLKLLLRWTHsl---ldECRERAStLLEQPDFMSICRSVAQIATKWG---LLEAAA 745  Drosop...
EDX17288             649 ANNFASILRFLDSVLGQAhQLTPQNLRVLLQWVEml---lrECREKSDlLMEQENFRGICCNIAATASKLT---PVESAA 722  Drosop...
XP_011604331         687 KKHFSTLLGLLGGLLLKE-HLYIETRRLLLTWAQEISvlmkKSDTYSP-LFSLTTFNKFCRGLLANALNEDQSICLQTCH 764  torafugu
XP_016845620         826 SGHLSIILNLIAKTIENK-RAPDQTLLLLLDWIQEIYl---QAENYIGvLSKTEECQTVVSSLLVCGATTNHKVSMAVCK 901  jewel ...
XP_023813689         699 KKHFSTLLSLLGGLLSKE-HLQPEARRLLLTWAQEISllmvKSDTYSP-LFSLPSFHKFCRGLLDNALHEDNGVSLHSCL 776  Japane...
XP_009297729         695 KRHFSTLLNLLGMLLSKD-HLNPEARRLLLTWSLEVAlmmkKSETYAP-LFSLPSFLKFCKGLLANSLNEDTTICLQACN 772  zebrafish
EKC30990             771 CLQDVYKINSnl---pINLIQSAVKLSVYKLS-DVRPEVRDGYLSLLRVLPANVTTRlysllhlggdndqsisvQEGAEG 846  Pacifi...
XP_414907            781 SLHALSSSLP------DDLLQRCVDVCRVQLV-HSGARVRQTFGKLLKSIPLDVVLS-----------------NRNHTE 836  chicken
EFZ20104             888 LLEMLMTAKNvv--wkQETYSSIVDLATLHLT-SCNKTIREKYGALLMCMPINIVIPklnkqylfsdtkkvreiVIYSTE 964  red fi...
XP_001947123         748 QILNIVLGNPtfcqskPLIVVDILDLCLSCIN-LTEHDISKQFYALIHKISLITVLQnvsicslknkskfnkkiNQMMSS 826  pea aphid
WGS:AAPP:GF21168-PB  700 CIQIVLDYGPekqehlLELLTLYRDMALQQLQ-VLSPNGHTPFSQIYAKLPLRITLTggdtpipgmssrrvcvwQQRMSQ 778  Drosop...
Q29I80               622 CMQAVLDFGPqalhtkQDLLVLYRDTALQQLQ-VLTTSGHAPYAQIYAQLPLHMTLFesglqg-----rrvcvwQQKMSQ 695  Drosop...
WGS:AAQB:GK16214-PA  746 CIQSVLGYGLts--qqDPLLLLYRDAALQQIKwILASNQLTVFAQIYAQLPLHVTLFaggvps-----priclwQQKISQ 818  Drosop...
EDX17288             723 CIQTVLDYGLerlakyPQLLILYRDTALQQLQ-MVSTNCHAPYFQIYAQLPLHLTLTgceslmpgmtsrrvsvwQQRISQ 801  Drosop...
XP_011604331         765 CIMVLSSSLS------TELLQSCVDVCRVQLV-NSAVRVRQAYGKLLKTIPLDVALS-----------------VQSQPR 820  torafugu
XP_016845620         902 NIESLLKAKQvs--wsEEIYSNIVDLATLHLT-SLDKTVRETYGHLLMNIPLNIVIPklnkagllsddkkfrniQNYSCE 978  jewel ...
XP_023813689         777 SLQLLLPWLS------SELLQRCVDVCRVQLV-HSTVRVRQAFAKLFRTIPLDVALS-----------------NHSVPE 832  Japane...
XP_009297729         773 SLQVLSSSLT------MELLQRCVDVCRVQLV-HSAVRVRQAFGKLLRSVPMHVALS-----------------AHSHSE 828  zebrafish
EKC30990             847 VTAAWLARRAHINRIPNGEFHAVNFRQIMAYILHDTSPiQSGSWNWLEAMFYSC-----QDAThdhkmietfRMSNFVDN 921  Pacifi...
XP_414907            837 IQEISLAIRSHMSKAPSNTFHPQDFSDVISFILYGSTH-RTGKDNWLERLFYSCqrldkRDQP---------TIPRNLLK 906  chicken
EFZ20104             965 --SLILAQRLHMRGNNNGELLAQHFKTYMAFLLQEHYLdASG----LSEMFTLCwpavpENGTt-------aRMYDLALA 1031 red fi...
XP_001947123         827 ----------HMRRKAVVTLKTEYFKNYMCEMIEPNTNnNDSTTHWLLDVVNSCsfdidSGET---------ELLSHAQH 887  pea aphid
WGS:AAPP:GF21168-PB  779 CSAV----------------RDSVFRDFFERLQHPE---QQPLTNSLRDLFVRScqvapQDERq-------eKLSQCTRR 832  Drosop...
Q29I80               696 CSAV----------------RDNVFQQFVDHLQRPE---QEQLTQCLRELFVRSyqvapPDERq-------eKLSQCTRR 749  Drosop...
WGS:AAQB:GK16214-PA  819 CSSV----------------RDTVFREFFEHLQQSE---QQQLNQSLRDLFVRScqisaMDERq-------eMLSHCIRR 872  Drosop...
EDX17288             802 WSAV----------------RDTVFRDFFERVQKPE---QESLVHCLRELFVRScqvapQDERq-------mNLSQCTKR 855  Drosop...
XP_011604331         821 MKDISLAVRHHMSRAPSSTFHPQDFSDLISFILYGTLH-RGGKDPWLERLYYSCqrfekLDGRgcadsgkpgVVPQALLK 899  torafugu
XP_016845620         979 --SLILAQRLHMR-SNNGEMQAQHFKTYMAFLLQEYYFdAFG----LSEVFTLCwptisDNETm-------aKMYELALA 1044 jewel ...
XP_023813689         833 TRHISLAIGHLMSRAHSTTFHPQDFSDLISFILYGVLH-RGGKDPWLERLYHSCqrlerRDCRggsdssrldLVPWALLK 911  Japane...
XP_009297729         829 IKEISLAIRRHMSKVPSNTFHPQDFSDLIGFILYGTVH-RGGKEPWLERLYHSCqrlekKDSA---------MVPRALLK 898  zebrafish
EKC30990             922 NEAMLWFWATWESAQYCVLNRLRTPLGKPQETFTSIEGVLKMFAKELDKPAEERNDISKtdqkkGGAKSSDLSSHLRVHL 1001 Pacifi...
XP_414907            907 TDAVLWQWAVWEAAQFTVLSKLRTPLGRAQDTFQTIEGIIRSLAAHTLNPDQDVSQWTT-----ADNDEGHSSNQLRLVL 981  chicken
EFZ20104            1032 NCSFLFFWSGFEAAQHCVLNKLRTSLGKPQDTFTSIESALKILAREISCHSNGVEKDVVrkerqG--LDRILHEHTRVRL 1109 red fi...
XP_001947123         888 CRVFLYFWINWEAANFCVINRLRTPFGKPNSTFRAIEGGIKMWARD--------SISALndetkVKHTEGKLNNLRYTRN 959  pea aphid
WGS:AAPP:GF21168-PB  833 CQRLATAWMQFEAARYCVDQRLRTTLGKPQETFLGFEAIIMRHARQLSGCGKEEERAALd----TLTLEELSNMQSNLVL 908  Drosop...
Q29I80               750 CQRLSAAWLQFEAARYCVDQRLRTTLGKPQETFLGFEAVIMRHARLLSGCAKEVERSSLd----GLSLEQLSAIQVNLGM 825  Drosop...
WGS:AAQB:GK16214-PA  873 CQRLAAAWMQFEAARYCVDQKLRTTLGKPQDTFLGFEAIIMRHARMLSGCAKEAERIDPd----GLSLMQLSNMQMNLNM 948  Drosop...
EDX17288             856 CQRLATAWLQFEAARYCVEQRLRTTLGKPQDTFFGFEAIIMRHARLLSGCAKEMERSAMd----TLSLEELLNMQSNLSL 931  Drosop...
XP_011604331         900 NEAVLWQWAAWEAAQFTVLSKLRTPLGRAPDTFQTIEGMIRSLAAHAVNPEQDVGAWAGs----GGDGDGHHSNQLRLAL 975  torafugu
XP_016845620        1045 NRTFLFFWGGFEAAQHCVLNKLRTPLGKPQETFTTIEGALKTLAREISC-----TAEIPkkdkrG--LDYLLHEHTRVRQ 1117 jewel ...
XP_023813689         912 TEAVLWQWAVWEAAQFTVLSKLRTPLGRAQDTFQTIEGIIRNLAAYCLNPEQDLGAWAGs----GGDGDGHHSNQLRLTL 987  Japane...
XP_009297729         899 TEAVLWQWAVWEAAQFTVLSKLRTPLGRAQDTFQTIEGMIRSLAAHSLNTEQELSQWSG-----GESDEGHHTNQLRLAL 973  zebrafish
EKC30990            1002 LLQFMEHLEKLLYNAYEGCAVSMPMSPKTVRTFFRTNKGTCLEWLSRVRSSVIKIALHSGMPAMAIRQCHQLLQEMK-DN 1080 Pacifi...
XP_414907            982 LLQYLENLEKLMYNAYEGCANALTSPPKVIRTFFYTNRQTCQDWLTRIRLSIMRVGLLAGQPAVTVRHGFDLLTEMKtNN 1061 chicken
EFZ20104            1110 LIEFLEHLERVIHNAADGCAMALLPLSKPVRTFFHTNKSTCKEWLNRIRLALCVVSLHSGLATSALRNGQRLLEDLS-NA 1188 red fi...
XP_001947123         960 LVAFIECLEKSVCNAIDGTATALPTAQKPVRHFFHTNRNTCYEWNSTIRSAMLAVALNSGLSSSAIRHGQYLVHHLT-KQ 1038 pea aphid
WGS:AAPP:GF21168-PB  909 MLGFLDALEKLIYNAAEGSAFALRPPEKPVAAFFRLNNPTCQSWFNRIRIGVVIIAVHVQQPELVIRYAQKILL-----T 983  Drosop...
Q29I80               826 LLGFLDALEKLIYNAAEGSAFALRPPEKPVAAFFRLNNPTCQSWFNRIRIGVVITAMHIQQPELVIRYAQQILV-----T 900  Drosop...
WGS:AAQB:GK16214-PA  949 LLGFLDALEKLIYNAAEGTAFALRAPEKPVSAFFRLNNPTCQSWFNRIRIGVVIIAMHSQQPELVIRYAQQILV-----T 1023 Drosop...
EDX17288             932 LLGFLDVLEKLIYNAAEGSAFALRPPPKPVAAFFRLNNPTCQSWFNRIRIGVVIIAMHVQQPELVIRYAQQILV-----N 1006 Drosop...
XP_011604331         976 LLQYLENLEKLMYNAYEGCANALTSPPKSIKTFFYTNRQTCQDWLTRIRLALMRVGLLSGKPAVTIRHGFDLLTEFK--N 1053 torafugu
XP_016845620        1118 LVEFLEHLERVIHNAAEGCAVALLPHSKPVRTFFHTNRSTCKEWLNRIRLALCVVSLHAGLATNALRNGQRLLEDLC-TA 1196 jewel ...
XP_023813689         988 LLQYLENLEKLMYNAYEGCANALTAPPKAIRTFFYTNRQTCQDWLTRIRLALMRVGLLSGQPAVTVRHGFDLLAEFR-SS 1066 Japane...
XP_009297729         974 LLQFLENLEKLMYNAYEGCASALTAPPKGIRTFFYTNRQTCQDWLTRIRLALMRVGLLSGQPAVTVRHGFDLLTEIK--N 1051 zebrafish
EKC30990            1081 NTLQGYDFEQTVLFLVKALVELKEGDAIMGVYNWCKEQTG--KKFLWIKALVEKATGKYESAAKELKNVLKVMVSSdSEK 1158 Pacifi...
XP_414907           1062 SLSQGNELEVTIMMLVEALCELHCPEAIQGIAVWSSAVVG--KSLTWINSVAQQAEGRFEKATAEYQEHLCAMTGVdCCI 1139 chicken
EFZ20104            1189 DNTQGIEFERATLWTAQAMVALGEAEALQGLYVYTKNK-D--RQFSWLKAAMEEAAGRYESAVDAYKQMIDEHVRV---- 1261 red fi...
XP_001947123        1039 SEFPVKEFILAIIQLAWAYSKLKESDCIRGLYVWSKEVAH--LKLPFLNILADQASGKFEEAAESYMNLLTTnsd----- 1111 pea aphid
WGS:AAPP:GF21168-PB  984 QKAQDATYSQAIVYLAWAWVCCQESDSLRGLYLWARSKSS--KSFQWLQCAADQAGGRKDAALAGYRSLLNETEEQpPEL 1061 Drosop...
Q29I80               901 QKTQDATYSQALVYLAWAWISCQEADSLRGLYVWARAKSSsgKSYQWLQHAAEQAAGRREAALSGYQNVLAEEGQR-QEL 979  Drosop...
WGS:AAQB:GK16214-PA 1024 QNPQDCSFSQAIVYLAWAWICCQEADSLRGLYLWARCKVSg-KTFQWLHCAADQAAGRKETALSGYSQILAEDD---AEL 1099 Drosop...
EDX17288            1007 PQTQDPTYSQAIVYMAWALISCQESDSLRGLRLWASSKSS--KSYKWLKYAADQAAGKRESALAGYKTILAEKEQQ-SEL 1083 Drosop...
XP_011604331        1054 SSAQGPEVEVLLTLLAEALCELNCPEAIQGLAAWSLLTSG--RSLGWLSSVALQAEGRFEKAALEYQDHLSAVTGMdCSI 1131 torafugu
XP_016845620        1197 NNTQGAEFERATLCTARAMVMLGEAEALQGLYVYCKEK-D--RKFVWLKAAMEEAAGKYELAAENYRRILEDQILT---- 1269 jewel ...
XP_023813689        1067 SSQQALELEVPLALMVEALCELRCPEAIQGLAAWSLQTCG--KSLGWVSSVALQAEGRFEKAALEYQDQLSAITGMdCSI 1144 Japane...
XP_009297729        1052 SSTQGPEMEVPVTMLVEALCELRCPEAIQGLAAWSLANTG--KSMGWLSSVALQAEGKFEKAALEYQEQLCAVTGMdCSI 1129 zebrafish
EKC30990            1159 ADSPRDdLSKVemi-----mpkKITG------ILSKQSPFPPPdsnipvlKVH-FVVTEIFDCYEKLYDWESVMEWQENV 1226 Pacifi...
XP_414907           1140 SGFDKTvLKLAnsnsvnnaspkHSLNgetrktVLTKPSDCSPE-------VIN-YLGNKACECYISIADWSAVQEWQNMV 1211 chicken
EFZ20104            1262 KATSDD-ECGG-----------GGGSgsgrsaRLESDNQ-----------VLG-FCMQRLSNCYKAVSDWSGLVEWKSRE 1317 red fi...
XP_001947123        1112 -----------------------------qiiIYLKGGGGSINniegpleVLQkFIIEQLKECYMSICDWKPLMDWSQNE 1162 pea aphid
WGS:AAPP:GF21168-PB 1062 DTHTRQ------------------------------------------------FVVAQMMQCLQDTGQWSQLVELKQRQ 1093 Drosop...
Q29I80               980 EPHTHQ------------------------------------------------FVLAQMMQCLQDTGQWSQLVDLKQHK 1011 Drosop...
WGS:AAQB:GK16214-PA 1100 EPHTRQ------------------------------------------------FVIAQKMQCLQDLGRWSRLVELKQKH 1131 Drosop...
EDX17288            1084 EPHTRQ------------------------------------------------FVVAQMMQCLQDLGQWSQLVELKQQH 1115 Drosop...
XP_011604331        1132 KSSDCFlPKFSnsts----spkHVNNgdnkktVLLKGNECSSE-------VIN-FLVNKASQCYVALCDWASVKEWQTTV 1199 torafugu
XP_016845620        1270 --RSKDdSKALei-------rcKNEG---------GDSQ-----------VAV-FCMDHLCKCFRSVGDWKQLEAWKQRE 1319 jewel ...
XP_023813689        1145 RTSPSClLKLSssvs---spkhSSSges-rktVLLKSAECSPE-------VIN-FLANKACQCYMALCDWSSVKEWQATV 1212 Japane...
XP_009297729        1130 KVFDRSlLKLTgtnt---sspkHTSSgegrktVLLKSSECSPE-------VLN-FLANKACECYVALSDWESVQEWQASM 1198 zebrafish
EKC30990            1227 LQYRQDysHLQAAFNSDVDL------NYIRALSAFEDGDF 1260 Pacific oyster
XP_414907           1212 HDLKKS--TSNTSINLKADF------NYIKSLSSFESGEL 1243 chicken
EFZ20104            1318 NEMLRQ----DSHAVLRRQMmenivqQQADCLKKFEKGEL 1353 red fire ant
XP_001947123        1163 ENLIPSi-AKDKYFWQNRYVs----aNDLQIVNDVEEGny 1197 pea aphid
WGS:AAPP:GF21168-PB 1094 LTRPED--SERNPFLQQSNVev---sALERLLAKSEEQSA 1128 Drosophila ananassae
Q29I80              1012 LLRPED--KELNSFLQCRNVdv---sAFERLLARTESNSn 1046 Drosophila pseudoobscura
WGS:AAQB:GK16214-PA 1132 LNRPED--SELNPFLQRSNVev---sALEKLLAKSEELSS 1166 Drosophila willistoni
EDX17288            1116 MMRPED--RELNPFLQRSNVev---nALERLLARGQEACS 1150 Drosophila simulans
XP_011604331        1200 HTLKQNs-SISGSINLRTDL------NYIQALSRFEEGDL 1232 torafugu
XP_016845620        1320 AEILDQ----DKNLCLRRQMleniapQQATCLRKFEEAEe 1355 jewel wasp
XP_023813689        1213 NTLKQNs-TNPVSITLRTDL------NYIRALSCFEDGDM 1245 Japanese medaka
XP_009297729        1199 MNLKKN--SSSSSVNLKTDF------NYIRAMSRFEEGDF 1230 zebrafish
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