Conserved Protein Domain Family
LRR19-TM
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pfam15176: LRR19-TM (this model, PSSM-Id:373623 is obsolete and has been replaced by 464545)
Leucine-rich repeat family 19 TM domain
LRR19-TM is the single-span transmembrane region of LRRC19, a leucine-rich repeat protein family. LRRC19 functions as a transmembrane receptor inducing pro-inflammatory cytokines. This suggests its role in innate immunity. This family of proteins is found in eukaryotes.
Links
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Statistics
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PSSM-Id: 373623
Aligned: 13 rows
Threshold Bit Score: 135.59
Created: 25-Apr-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003782893 256 NLTRDSEHGPL-GKSWAFLVGVVVTVLMTSFLIFIAIKCPIWYNILLSYNHHRLEE------HE------VETYNESFNG 322 small-eared galago
XP_005334245 256 NFTRNSEHEPL-GKSWVFLVGVVVTALMTSLLILTAIKCPIWYNFLLSYNHRRLEE------HE------AETYEDGFPG 322 thirteen-lined ...
Q8BZT5       250 NLTWTSEHEPL-GKSWAFLVGVVATVLLTSLLIFIAIKCPVWYNILLSYNHHRLEE------HE------AETYENGLTR 316 house mouse
XP_007498146 257 nKTKNAESEPS-GKSWALLVGVVVVVTVTSMLIFIAIRCPTWYNFFFSYNHHRLDE------QE------ADTYEGDFTV 323 gray short-tail...
XP_012399493 259 NVTKNAESESL-GKSWAFLLGVVIVVLVTSLLIFIAIRCPTWYNFLFSYNHRHLDE------QE------DDIYE-DCTI 324 Tasmanian devil
XP_003431607 256 NL-KNSERKLL-GKSWALLVGVVVTVLMTSLLIFVAIKCPIWYNFLLSYHHHRLEE------HE------AETYEDGFTG 321 dog
1_pfamImport   1 ---SAASNGRS-SNTWQYLVAVVGTALGLSALITLSVKCKFFHKYLLSYRHQPLPE------SE-------DDRPGGLAH 63 
XP_008107673 245 TSTSTPPLEKT-GRSWPYFAGFILLAAGISILIALVAKCILLRRNRASYQHQRLPD------SRsvgsshAEEADMGVAY 317 green anole
ETE73383     152 AANTTPATQTA-GKNWIYFAGFVLLAITISLLIALIVKCKLLQKKHASYHHQRLPD------SRsigschIEERDMDMTY 224 king cobra
Q28E90       223 LTSPAPDTAKSnGRSWPYLVGFIVIAICLSLIIALAAKCNVFHRYLRSYRHRPLPE------NDwinqsqTE-------- 288 tropical clawed...
XP_003407373 256 nLTRNPEHERF-GKSWAFLVGVAVSVLMTSLLIFIAIKCPLWYSFVLSYNHHRLEE------HE------AETYEDGCTG 322 African savanna...
XP_023181740 253 CTVSKCQKPLS-GHTWKFTACVAALALITCILILTAIKGPSWYKSFHNYRHRRLVEddeeggQD------TMTTETGGCE 325 southern platyfish
XP_005050250 247 nntTALPAVKG-GRSWPYLVGFIVTAIGISILIALAAKCKLAHKNFASYRHRPLPE------ISsiggspMED---TSSW 316 collared flycat...

XP_003782893 323 NPS--SFSQISATNPEDttviferlhsfvvDDDGFIEDKYIDTHELCEEN 370 small-eared galago
XP_005334245 323 NSN--SLPHIGDINSEDttvifeqlhsfvaEDDGFIEDKYIDTHELCEEN 370 thirteen-lined ground squirrel
Q8BZT5       317 NPS--SLSQITDTNSEDttvifeqlhafvvDDDGFIEDRYIDINEVHEEK 364 house mouse
XP_007498146 324 YPN--SLPQTPDTNPDDsivifdqlssfmvDEDGFIEDKYIDTQEMREEN 371 gray short-tailed opossum
XP_012399493 325 YSN--SLPKTRDTNPEEnimifdqlssfvvDEDGFIEDKYIDTQEMHDEN 372 Tasmanian devil
XP_003431607 322 NSS--SLSQVPDTNSEDttvifeqlhsfvvDDDGFIEDKYIDTHELHEEN 369 dog
1_pfamImport  64 GGV-----PRLPQHDE--------------DDDGFIEDNYIQASDRREEE 94 
XP_008107673 318 GRN--P--PGAGCPAD--------------DDDGFIEDNYIEPNRDMREe 349 green anole
ETE73383     225 GRN--Q--PASECYPE--------------DDDGFIEDNYIVPNQDLKEE 256 king cobra
Q28E90       289 ------LPGVPLPPNE--------------DEDGFIEDNYIQPEDHHEEE 318 tropical clawed frog
XP_003407373 323 NPS--SLSPAPNTNSEEttvifgqlpsfavDDDGFIEDKYIDTHELHEEN 370 African savanna elephant
XP_023181740 326 SQQtfTFEELSHRIQEQ-------------EEDGYFEDPYIKRMEDSEEE 362 southern platyfish
XP_005050250 317 DRG--SIPDAADLQAE--------------DDDGFIEDNYIQPSEQLPtk 350 collared flycatcher
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