Conserved Protein Domain Family
DDE_Tnp_4
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pfam13359: DDE_Tnp_4 (this model, PSSM-Id:372577 is obsolete and has been replaced by 463855)
DDE superfamily endonuclease
This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.
Links
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Statistics
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PSSM-Id: 372577
Aligned: 46 rows
Threshold Bit Score: 106.208
Created: 30-Apr-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EDO37985  98 IDGFEGKC--QIPQlagAIKavrfkIKAPSLVTHKMKYyndnlkchSMTLQA--VTDSSGKFLD-VSTGYPGGITNTEAL 172 starlet sea anemone
EEY62421  57 FDGTLVRT--QRPK---D---------------FQSGKp-------SYNCLA--AIDYRYKFRY-LGV-FSGSNSDQSMW 105 Phytophthora infest...
AAI62733 167 IDGKHVVI--KAPD---N--------SGSLFYNYKGTY--------SVVLLA--VVDSQYRFRV-VDVGSYGRMSDGGVL 222 zebrafish
EDS27651 118 LDGKHITI--QAPP---N--------SGSTFFNYKKTF--------SVVLLA--LVDANCNFIA-VDVGAYGRNSDGGIF 173 southern house mosq...
EDR09894  75 YDGTIVVLy-KKPG-----------LNGDAYYTRKGNY--------GLNTQVdwKYPLNLRIVD-YSHGMTGSAHDTMAF 133 Laccaria bicolor S2...
EED86813  12 MDGTLFPLafQPET-----------EDAADYHGRKFQW--------SLTCLV--VSDQKRRIRW-YITGYPGSAHDNRML 69  Thalassiosira pseud...
EEY67322 101 TDGTLFPLa-AKPQ-----------HQGEGYSSRKASY--------SVHGLV--TCDDVGSVRS-LVVGWPGSTHDNRAW 157 Phytophthora infest...
EEY65939  14 TDGTLLPLa-TKPR-----------HNGEDYYSRKSSY--------AVNALV--TCDDIARVRN-VVIGWLGSVHDNRVW 70  Phytophthora infest...
EDR00075 217 MDGLNLPV--QTSP---DQE-----IENTTFNGWLHDH--------FVSSVF--AFSAKGEIIT-CNLNAPGSWHDSRVA 275 Laccaria bicolor S2...
Q54RV8    99 LDTTVFPI--RT-------------MDDQFYSIKHSKR--------CLKYEA--IVTLDKGTCChLTGPHVGSELDLVVY 153 Dictyostelium disco...

EDO37985 173 AMS-DIYKNVKqgvilnsps----atveglqvkPIIATDASYK--LRKw---cI-CPYP----------DNNML-SPSQE 230 starlet sea anemone
EEY62421 106 NQS-AVLGAharel---------------cppgINWLGDAGFK--PWPf---lM-VPFDe--------rGGKRL-TAKQR 154 Phytophthora infest...
AAI62733 223 ANS-IFGQALRdgalglpqdallsgaehfgpqpHVFVADEAFP--LRRd---lM-RPF-----------PGHNL-SGRQR 283 zebrafish
EDS27651 174 ASS-VLGKALAgnrlnvpeaa--plpgtntltpHVIVGDEAFP--LKPy---lM-RPY-----------PGDNL-DNAKR 232 southern house mosq...
EDR09894 134 EHT-TAAKYpdwf----------------fegeEFAWADSAYA--VNS-----RtIPVH----------KKPASdDPANA 179 Laccaria bicolor S2...
EED86813  70 RRS-PLKVRkeey----------------ftvyQYIIGDTAFD--PSE-----NvVPAYka------npNKAEPdDPDER 119 Thalassiosira pseud...
EEY67322 158 MNS-PLILKradh----------------fkhnEYVLGDSAFQ--ASS-----VmIPAFkn-------pPKAQM-NPRHT 205 Phytophthora infest...
EEY65939  71 SNS-PVCQNpdlh----------------fehnEYLLGDSAFQ--ASR-----TmIPAYkk-------pPKADM-HPSNS 118 Phytophthora infest...
EDR00075 276 RPIyEKLRAqtp-------------------egYYLVTDTAFPrgTDQiagriR-APMKdgarlplnrlERERL-----L 330 Laccaria bicolor S2...
Q54RV8   154 IKE-VAHLDll--------------------pgEKIFADEDFC--CNEfssklI-RPIKk--------tHETML-TNEEH 200 Dictyostelium disco...

EDO37985 231 RFNSELGSAVHIAEDALARLRgRWNTLa--GSCLDEN---VEKIPETVLICCVLHN 281 starlet sea anemone
EEY62421 155 CYNYHLSQTRILVECVFGKLKpRFKTL---HGVTDRKk--HNTNARMITAAAVLHN 205 Phytophthora infestans T30-4
AAI62733 284 IFNYRLSRARLIVENTFGILTaQWRMY---RGAIEIS---PANVDACVKATCVLHN 333 zebrafish
EDS27651 233 IFNYRLSRIRRASENTFGIYMqMFRIF---NRPIQAK---PENVDKIIMAAIVLYQ 282 southern house mosquito
EDR09894 180 LFDKAVA----HLQHCMGALKgRFQCLrglHVSINSKq-dHHDACHWIIIAIILHN 230 Laccaria bicolor S238N-H82
EED86813 120 LLNKVISKPRVSSEHVNGMWKgRFPWLrliPNRVRDKk-sLTEVMKYIHCTVILHN 174 Thalassiosira pseudonana CCMP1335
EEY67322 206 YFNKQLAKARIKSEHCIRLLKmRFPYLreiRVKLGKKrkhIRRLIRHVTCASILHN 261 Phytophthora infestans T30-4
EEY65939 119 YFNNQLAKARIKSEHCIGLLKmRFQYLrevRVELGKKrkhMRRLIRYVKCACIIHN 174 Phytophthora infestans T30-4
EDR00075 331 QEDRQLLSYRQTAEWGMRTIQgTFGCL---HVPLQIAy--HEIRGDLLETCARLFN 381 Laccaria bicolor S238N-H82
Q54RV8   201 CFNNWVSSNGIIVKNFFKDLK-KFEILkdwRSS-------IDKHMKMVYFLTWVVN 248 Dictyostelium discoideum AX4
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