Conserved Protein Domain Family
RHIM
?
pfam12721: RHIM (this model, PSSM-Id:372270 is obsolete and has been replaced by 463679)
RIP homotypic interaction motif
RIP proteins are receptor-interacting serine/threonine-protein kinases or cell death proteins. This interacting domain is involved in virus recognition. The RHIM domain is necessary for the recruitment of RIP and RIP3 by the IFN-inducible protein DNA-dependent activator of IRFs (DAI), also known as DLM-1 or Z-DNA binding protein (ZBP1). Both the RIP kinases contribute to DAI-induced NF-kappaB activation. RIP3 undergoes auto phosphorylation on binding to DAI.
Links
?
Statistics
?
PSSM-Id: 372270
Aligned: 31 rows
Threshold Bit Score: 29.7169
Created: 1-May-2019
Updated: 18-Jul-2019
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
EEN45414      145 EEPLTTKS-------SLTSETdatddiEGACGSTS-------------LPPRACPGngptpvTVQVENAFAVQVGNGNVL 204  Florida lancelet
XP_015155511  674 PSPSQ----------------------PLNLPSGQ-------------HYTTTDPGga---rSIIIQHARMVQIGNHNTM 715  chicken
Q80UF7        655 PVSSPQ---------------------SQSFPSAS-------------SPAPQTPGp----qPLIIHHAQMVQLGVNNHM 696  house mouse
EGV93716      618 PVSSPQ---------------------SPPFPSAS-------------PAATQTPG------PLIIHHAQMVQLGVNNHM 657  Chinese hamster
XP_014978020  653 SLPFSQ---------------------PPAFPTAS-------------PAPPQSPGl----qPLIIHHAQMVQLGLNNHM 694  Rhesus monkey
AGT36583      655 PPAFPQ---------------------PPAASQSS-------------PVNPQSSGv----qPLIIHHAQMVQLGLNNHM 696  pig
Q06A28         19 dvPMPDDG-------QGGQQT------ATTAAGGA-------------FGVGGGHSvp---yVRIMNGVSGIQIGNHNAM 69   Murine cytome...
CAF91598      503 SKPHLATSvsmpfipQPNRENhcvldrqkswstfpvtdtsapeinpgsllapsnsrlrqdsgPLIIQNANGIQIGSNNQM 582  spotted green...
XP_023500240  655 PPAFPQ---------------------PPAFPQPP-------------PVPPQSPGl----qPLIIHHAQMVQLGLNNHM 696  horse
ANV78028      708 PSPSQ----------------------PFHLPSGY-------------HNAMPEAGga---qPIIIQHARMVQIGNHNTM 749  mallard

EEN45414      205 IS 206  Florida lancelet
XP_015155511  716 HV 717  chicken
Q80UF7        697 WG 698  house mouse
EGV93716      658 WG 659  Chinese hamster
XP_014978020  695 WN 696  Rhesus monkey
AGT36583      697 WN 698  pig
Q06A28         70 SI 71   Murine cytomegalovirus (strain Smith)
CAF91598      583 NF 584  spotted green pufferfish
XP_023500240  697 WS 698  horse
ANV78028      750 QV 751  mallard
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap