5ZSU


Conserved Protein Domain Family
Pannexin_like

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pfam12534: Pannexin_like (this model, PSSM-Id:372171 is obsolete and has been replaced by 463622)
Pannexin-like TM region of LRRC8
Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.
Statistics
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PSSM-Id: 372171
Aligned: 49 rows
Threshold Bit Score: 382.73
Created: 1-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5ZSU_A         1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCK---------------------- 58   human
4_pfamImport   1 MFSLSELAPLNQHQGRCKLLKPWWEVFMDYLVVLMLMVSVLACTEQLSRDRVVCIPMDpvt------------------- 61  
XP_009297371   1 MFALSELWSGGERQGSYKLLKPWWEVFMDYLLVLMLMVSILAGTLLLSRDGVVCVPV----------------------- 57   zebrafish
XP_014347654   1 MFTVTDVAFIGESQASNKILKPWWDVLMDYLVFSMLMLSIFSGTLLLLKDAVACVPMDfperg----------------- 63   coelacanth
XP_006002308   1 MLPVSDISFLGESQITHRIFKPWWDILMDYIIYSLMILSVIGGADLLFPNVVLCLPM----------------------- 57   coelacanth
XP_007229860   1 MFTLSELWSISERQGRYKLLKPWWEVFMDYLVLLMLMVSILAGTLLLSRDGVVCVPV----------------------- 57   Mexican tetra
XP_011476887   1 MFSLSELAPPNQHESRCKLLKPWWEVFMDYLVVLMLMTSVLACTEQLSRDRIVCIPVDpls------------------- 61   Japanese medaka
XP_023205001  80 MFSLSELAPVEPQQNTWKLLKPWWEIFMDYLVVLMLMTSVLACTVQLSRDRVVCIPSEpp-------------------- 139  southern platy...
XP_003443213   1 MFSLSELAPLNQHQNRSKLLKPWWEVFMDYLVVLMLMTSVLACTEQLSRDRVVCIPLDst-------------------- 60   Nile tilapia
XP_007245147   1 MFTLTEVASLNDVQPTYRILKPWWDVFMDYLGLVMLMLAIFAGTMQITKDQVACLPFLeerskiesttpytthgsmytst 80   Mexican tetra
5ZSU_A        59 -------WVTKDSCNDSFRGWAAPgpepty--pnstilPTP-DtgPTGIKYDLDRHQYNYVDAVCYENRLHWFAKYFPYL 128  human
4_pfamImport  62 ----sanTSNHGPSTSGP-ALTPSskppthvprnvspkLPP-V--GRGRRTHLAHQQYVYISQVCYHEALPLCSRFFPYM 133 
XP_009297371  58 ----------HSFPTNHTSTIDPIpet---------afTST-S--ARGRRTNLDFQQYSYISQVCYHEALPWYSRFLPYV 115  zebrafish
XP_014347654  64 --nsvptAASTQNSESTPSHLDPTaqahtifastsepsFIPeT--VRGRPTKLDYQQYVYINQVCYQKAVPWYSKYFPYL 139  coelacanth
XP_006002308  58 --------EQFGEGDDLAQRVSVAadamkvylesaqreMNP-D--LKPPNTNLDLQQFYYINHVCYEKAFPWFSRYFPYV 126  coelacanth
XP_007229860  58 ----------HSLSNNYSSGFRTPsdspvlpftsgsalAEG-P--AKGRRTNMDYQQYVYISQVCYHEALPWFSRFLPYI 124  Mexican tetra
XP_011476887  62 ----ppcMSNHSMAQNSD--VKPSpapkstnpqnpgpnFYS-A--PRGRRTHLVHQQYIYISQVCYHEALPFCSRFFPYI 132  Japanese medaka
XP_023205001 140 -----fnASDGVHPPVGSDAVLASseaplhvphsigpnLQS-P--AQGRRTHLVYQQYIYVSQVCYHEALPFCSRFFPYM 211  southern platy...
XP_003443213  61 -----tnTTDHSHSKSANVGLSPSsqpqihhahkigpnLHS-A--PRGRRTHLVYQQYIYISQVCYHEALPLYSRFFPYM 132  Nile tilapia
XP_007245147  81 sslgtapLATQDLPDSVVHELHHTepttparsqsimtaTEP-Q--PKGRRTNLDYQQYIFVNQMCYHVALPWYSKYFPYL 157  Mexican tetra
5ZSU_A       129 VLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEESDPKPAFS-------------------- 188  human
4_pfamImport 134 AMLQSLVLVASGSFWLHFPHTSARIEHFLAILAKCCESPWTSQALSHAARQDSIQEKEVV-------------------- 193 
XP_009297371 116 TLLHTLVLLASGCFWFHFPLTSARIEHFLSLLAKCCESPWTTRALSHTAKLDTRFSEAEP-------------------- 175  zebrafish
XP_014347654 140 ALMHSLVLLVSNNFWFRYPKTSSKIEHFVSILGKCFESPWTTKALSETACEDSESN------------------------ 195  coelacanth
XP_006002308 127 VLIHSIVLLVSNNLWFQFPKTSAKIELLVSVLEKCFESPWTIKALSKKSGKKESNGIQN--------------------- 185  coelacanth
XP_007229860 125 TLLQSLVLLASGCFWFHFPLTSARIEHFLAILAKCCESPWTSRALSRTAKLDSAHNRPHE-------------------- 184  Mexican tetra
XP_011476887 133 ALLQSLVLVASGSFWLHFPDTSSRIEQFLSILAKCCESPWTSQALSHAARQENIQELEKA-------------------- 192  Japanese medaka
XP_023205001 212 ALLQSLLLATSGSFWLYFPHTSSRIEQFLSILAKCCESPWTSQALSQAARQENIRDLERP-------------------- 271  southern platy...
XP_003443213 133 ALLQSLILVASGSFWLHFPHTSSRIEQFLAILAKCCESPWTSQALSHAAHQESIQEMVEEgrrahqphhrtstsptvtht 212  Nile tilapia
XP_007245147 158 VLIHTILLMVSSNFWFKYPKTSSKIEHFVSILGRCFESPWTTKALSETACEDSEESKQRI-------------------- 217  Mexican tetra
5ZSU_A       189 ---------------KMNGSM-----------------------------------------DK---------------- 196  human
4_pfamImport 194 ---------------EEERRApqp-------------------------------------------------------- 202 
XP_009297371 176 ---------------VVQPKAqvassykmrkssl---------------dsgtdspllagidTAst-------------- 211  zebrafish
XP_014347654 196 --------------------------------------------------------------PNrl-------------- 199  coelacanth
XP_006002308     --------------------------------------------------------------------------------      coelacanth
XP_007229860 185 ---------------EEQVVKpqahpiltsitrqssmdsgtdspllvrtgststtaaqpspcPSsl-------------- 235  Mexican tetra
XP_011476887 193 ---------------ERQPFLsa--------------------------------------------------------- 200  Japanese medaka
XP_023205001 272 ---------------PRHAAA------------------------------------------Saawfsiapartghsst 294  southern platy...
XP_003443213 213 rhssidsgtdspllkRMDSACatpp----------------------------------spcPStl-------------- 244  Nile tilapia
XP_007245147 218 ---------------IAGQTS-----------------------------------------SKqv-------------- 227  Mexican tetra
5ZSU_A       197 ------------------------K---SSTVS-EDVEATVPMLQRTKSR--------------IEQGIVDR-SeTGV-- 231  human
4_pfamImport 203 ---------------------plsSassSHPVTlARRTSRDSGTDSPLL---------------------ESpRqVMS-- 238 
XP_009297371 212 -----------------------tTqpsPCPSTvSHCSAFSTRSLTEPVH--------------AVQVSPDRsRpGAT-- 252  zebrafish
XP_014347654 200 -----------------------nVsipKHSDTeAKEGIDIPLVPNPEAS--------------FEKPVFEVpS-VTI-- 239  coelacanth
XP_006002308 186 ------------------------R---LSVLArNRFSVNLQKDTDNPSA--------------PSNQVSAKnPtSKVpv 224  coelacanth
XP_007229860 236 -----------------------sRcstLSSLSiPEPASLPKPAPVVP----------------------EGsRpGPT-- 268  Mexican tetra
XP_011476887 201 ---------------------------aSSWVTrTRRSSTDSGSVSPLLKsvsslsvgsgvhcpSSKAGPDSpReVMS-- 251  Japanese medaka
XP_023205001 295 dsgtdspllkksayppspcpstvsSnstMSSVSlGSETHLCSSEPPVNS---------------------ERpGqVLS-- 351  southern platy...
XP_003443213 245 -----------------------sCnstVSCVSlDSREQLPSSSPSVMA---------------------DShSqVIS-- 278  Nile tilapia
XP_007245147 228 -----------------------sT---DSQEEaTSPTSPMLINTEVTFS--------------TERMVPEGqS-LTI-- 264  Mexican tetra
5ZSU_A       232 -LDKKEGEQAKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDIESLTGYRTYRC 310  human
4_pfamImport 239 -LDKSDGEQARALFERVRKFRSHSESSDVIYKVYLAQTVLKLLMVTLILSYSIPLLSSLSFTHTCHPEETALVGYDTFQC 317 
XP_009297371 253 -LDRSDREQARALFERVRRFRAHCESSDVIYKVYTAQTVFKVLKFVLIVSYTTPLLSCISFSHVCRPHSDALIGYSEFQC 331  zebrafish
XP_014347654 240 -LDKTDGEQAKALFEKVRKFRAHIEETDFTYKFYVGQAVFKVVKFLVVLSYTCTIVDHIQFFYICKPKIRNLTGYSKFYC 318  coelacanth
XP_006002308 225 hFNKTAGVQAKALFVRARRIHAYIERWDFIYKFYVGQSMFKALMFIVPLLLTSAMLDNVSLISICKPKIRNLTGYSRFYC 304  coelacanth
XP_007229860 269 -LDRSDGEQARALFERVRRFRAHCESSDIIYKVYVAQTVFKVLKFVVIVSYTAPLLGSISFNHICQPHSHTLTGYQVFQC 347  Mexican tetra
XP_011476887 252 -LDKSDGEQARALFERVCKFRSHCESSAVIYKVYVAQTTFKLFLVLLILSYTIPLLNSLSFNHVCRPEEWELVGYATFEC 330  Japanese medaka
XP_023205001 352 -LDKSDGEQARALFERVRKFRSHCESSAVIYKVYLAQTIFKLLMVSLIMSYTVPFLSSLSFSHVCQPAEQTLVGYTTFEC 430  southern platy...
XP_003443213 279 -LDKSDGEQARALFERVRKFRSHCESSAVICKVYLAQTVFKLLIVTLIMSYTVPLLGSLSFNHTCHPEERALVGYATFEC 357  Nile tilapia
XP_007245147 265 -LDKKDGEQAKALFEKVRTFRAHVEDSDFIYNLYVAQTSVKALKLIFILCYTSTFTSEIKFKHVCKPEIEHLTGYDEFFC 343  Mexican tetra
5ZSU_A       311 AHPLATLFKILASFYISLVIFYGLICMYTL 340  human
4_pfamImport 318 IHVLSSLLRKLLMAYLSLLGLYAMLNFYTL 347 
XP_009297371 332 SHPLSSVLRQLMQAYVSLLFLFGLLAIYAL 361  zebrafish
XP_014347654 319 THNLAFVISKLLITYMILIIIYGLLSIYNL 348  coelacanth
XP_006002308 305 IHNYAFLTKSLMVTYIVLIGVYGLIGIYVL 334  coelacanth
XP_007229860 348 SHSLASVLRKLMLAYVSLVGLYGLLGIYTL 377  Mexican tetra
XP_011476887 331 VHVLSSLLHKLLVAYLILLGLYTLLNLHTL 360  Japanese medaka
XP_023205001 431 VHSLSSLLRKLLVTYLILLGIYALLNFYTL 460  southern platyfish
XP_003443213 358 IHVLSSLLRKLLVAYLTLLGLYGLLNFYTL 387  Nile tilapia
XP_007245147 344 THNMAFMLRKLLFTFMAIISLYGLVCMYAL 373  Mexican tetra
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