5OGS,4C8S


Conserved Protein Domain Family
Mcl1_mid
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pfam12341: Mcl1_mid (this model, PSSM-Id:372058 is obsolete and has been replaced by 463539)
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Minichromosome loss protein, Mcl1, middle region
Mcl1_mid, or the middle domain of minichromosome loss protein 1, is the domain that lies between a 7-bladed beta-propeller at the N-terminus, family WD40 pfam00400 etc, and a Homeobox (HMG) domain, pfam00505, at the C-terminus. The full length proteins with all three domains are referred to as DNA polymerase alpha accessory factor Mcl1, but the exact function of this domain is not known.
Links
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Statistics
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PSSM-Id: 372058
Aligned: 122 rows
Threshold Bit Score: 188.161
Created: 1-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5OGS_A    107 KPFQSGST-PLH-LT-HRFMVWNSIGIIrcyndeQD------NA-IDVEFHDTSIH-HATHLS-NTLNYTIADLSHEAIL 174  human
EAX94780  545 gPFMPGSSqdy--dgsRRFLCWNETGVIflreidEDr-----EA-IDVEFADVFSN-RNVSFS-NDRHFLLATLNKEGFC 614  Trichomonas vagin...
EWS72657  475 diiyPSSV-SKQ-LN-RSCILWNLVGQIilreedRNl-------fLEFDFPDKEFH-SRITIK-NLHNYSMAAMNRQGFI 542  Tetrahymena therm...
Q8IER6    773 iVLAPGLCeepenindQWCMFWNDIGHItkkkegSK-------TyIYIFLFRGEEI-GKKKIT-DIYNVTSASLSAYGFA 843  Plasmodium falcip...
EGG20975  527 ASFQPGSTlfln-nkkRYFMAYNMIGCIvkr-eeeDekl---pgsIEIEFNEASVH-RKVTIT-DNNMLDMGALGEKGAI 599  Cavenderia fascic...
CBZ08475  588 YSFQVGAT-PAG-EEgNCYLAYNSVGYIhcs-----------rdaTTVHFHDIS-H-PAVRLQ-LRGTVLMGTLSPVGAA 651  Leishmania infant...
Q4E5R7    564 YSFQIGAT-PVG-EEgSCYLAYNSVGYIhst-----------adgTNIHFHDMS-I-QAVRIL-ERGTILMAALSPVGAA 627  Trypanosoma cruzi
Q4GYD0    615 yfFQIGAT-PPG-EEgSCYLAYNSVGYIhct-----------aeaTTIHFHDMS-L-QAVRVL-ERGTMLMASLSPVGAA 678  Trypanosoma brucei
EGB08065  277 PPFMVSSTvAEE-ETaARFLHWSHRGSVt----aRAeeggleFA-FEVEHYAEGAArGRVVRFvDRRDFTLGTLGARGAF 350  Aureococcus anoph...
EEC44446  592 PAFGPSST-SLE-LT-RRFLCWNHIGSVtf---lRGqaginrST-IDIHFTDSAFR-RPVSFT-DNMGFILGSLGEDGGI 662  Phaeodactylum tri...

5OGS_A    175 L-ACEST-D-EL--------------------------------ASKLHCLHFSSWDS--SKEWIIDLPQNEDIEAICLG 217  human
EAX94780  615 A-A------------------------------------------SRTYFQYRSNNPKsiPSEFSHKFTDSETIDLIAIG 651  Trichomonas vagin...
EWS72657  543 L-ASKAInSsQEyeseedfer--------------fdfhqdaysYSCIYFQSLSKSDK---TLWSLKLGQDENVETVAIG 604  Tetrahymena therm...
Q8IER6    844 LaSNPYEkSgNKn-------------------------------NSILCFHNLKDN-----IIWNKYLPSDEYIKGVANG 887  Plasmodium falcip...
EGG20975  600 F-ASSRK--------------------------------------NLLHFNAFDSLGA--SSSWTYTIAANDPIVGVAIG 638  Cavenderia fascic...
CBZ08475  652 FiVLPADpTeAQgsvd-------------------------eapRLSVLYHAFTPLGA--QSEWRVALLPGETVRCMAAG 704  Leishmania infant...
Q4E5R7    628 F-VLTQDa-eMDsvd--------------------------dtpRLTLYYRTFVALGA--QSDWRVRLYPGETVRCLTAG 677  Trypanosoma cruzi
Q4GYD0    679 F-VIAQEaTdMEsvdd-------------------------lvpRLTIYYRTFVSIGL--QPDWRLRLHTGEVVRCIATG 730  Trypanosoma brucei
EGB08065  351 F-ATGGDdLdE----------------------------------SQLYFRPLSSWAS--DGGWSAKLPPGEFATTLAAG 393  Aureococcus anoph...
EEC44446  663 F-ATDLAeDeDIdeedddmdglnvsaatkaavkrsrkgpsnkptGSSIYFHRFETFGSlrDKDWYLTLPDGERALGCASG 741  Phaeodactylum tri...

5OGS_A    218 QGwAAAATSALLLRLFTIGGVQKEVFSLAGPVVSMA-GHGEQ------------LFIVYhrg-----tgFDGDQCL---G 276  human
EAX94780  652 KRwVAVATELGRIHIFKSSGFEYASLSLPDRLLTMV-GGKDR------------LFVVF-------------GDTL---D 702  Trichomonas vagin...
EWS72657  605 DGwCAVQTDLQYIRIYSFSSMEQHCFCIDKPAVCIS-GYKNI------------LAIVYleg-----epIYGCQSI---K 663  Tetrahymena therm...
Q8IER6    888 NNfVAVVTSNNFLRIYSTYGYIINTILLKGLPVAIC-AYDYL------------LFIITcpyiyenvttTNINNTYtctL 954  Plasmodium falcip...
EGG20975  639 SKyIAACSHHRTVRIFTLGGVQFTQLSIGGDFVTMSiSCKDV------------LALVYgta--------------dqmT 692  Cavenderia fascic...
CBZ08475  705 IRyVAVAT-SHYLRIFSLSGLELAVLSKSQRIVTMV-GTSSRklmssfkadfdpLVIIS----------LTGTGEL---Q 769  Leishmania infant...
Q4E5R7    678 IRfTAVAT-SRYLRLFSLSGLELAVLSLFPRIVAMV-GTNSSkimhsfkadfdpLAVCY----------LESGGEM---R 742  Trypanosoma cruzi
Q4GYD0    731 VRyTAVAT-SRYLRIFSLSGLQLAVISLFPRIVAMV-GTNSKkvmqgygadfdpLAVCY----------LEGGGEL---R 795  Trypanosoma brucei
EGB08065  394 DDwVAATTSRDLLRIYSGGGVEDAVVGGLGRAVACC-AHKRS------------LAVAYhrs----sptADGQQDV---W 453  Aureococcus anoph...
EEC44446  742 EGwAAVVTSRRFLRLFSSGGNQGEVLWLNGHPVTMA-GRGRF------------VAVVYhes----tplPDGTQKL---G 801  Phaeodactylum tri...

5OGS_A    277 VQLLE--L-GKK------KkqiLHGDPLP-LTR-K-----------SYLAWIGF-SAEGt--PCYV-DSEGIVR--MLNR 328  human
EAX94780  703 YWLLDipNri-----------kLASGVIP-VA--------------KPLRWVTF-DENd---NVYAlGNDKILVelVFDf 752  Trichomonas vagin...
EWS72657  664 LKFFD--VnSGE------M---IKEIGVP-LTP-F-----------TTLTWFGF-SEEG---LVLTkDSKGVIR--ALIg 713  Tetrahymena therm...
Q8IER6    955 YKIYEnfTnLKPskyntyHitiLYEDVLS-L-PsC-----------HYLNWVNM-SNFGv--PYVK-DTSNYIY-----G 1012 Plasmodium falcip...
EGG20975  693 LVCQD--LnTGN------I---IYQGPIC-IST-N-----------ATLKWIGF-SNNSdttLTTV-DSNSVVR--TLTR 744  Cavenderia fascic...
CBZ08475  770 MEVIDv---------------gARTSALP---PrTvpltelpdgstHQLQWLGW-SEDG---LLHIvDTAGVVR--QFTE 825  Leishmania infant...
Q4E5R7    743 LQVLDv---------------gSRSVVLP---PvVvpltthsdgslHQLQWMGW-SEDG---PLHFaDTAGVLR--MFTF 798  Trypanosoma cruzi
Q4GYD0    796 LQVLDv---------------gSRSVVVP---AtTvpv-----tttHQLQWMGW-SEDG---PLHIaDTAGVLQ--MFTQ 846  Trypanosoma brucei
EGB08065  454 IQVLD--VeGRA------Av-nGDGSRLP-LPP-G-----------SKLAWLGFkTDDGv--LLAK-DSSGSFW--MLVD 506  Aureococcus anoph...
EEC44446  802 YLVLD--AmANR------V---VAKGPVScISG-A-----------STLSWLGF-SNDGs--LLAM-DSDGMLS--MLVC 852  Phaeodactylum tri...

5OGS_A    329 glg----------ntWTPI------------------------------CNTREHCK---G-Ks---------DHYWVVG 355  human
EAX94780  753 g------------fhWQAMsnlrnvisegkveenenksdesdesdlgldIDKKKSTNddgSyQldhaekeiytD-FWCVS 819  Trichomonas vagin...
EWS72657  714 y------------snWTPI------------------------------YEQPHn------------------KNFWLKG 733  Tetrahymena therm...
Q8IER6   1013 lypifkk-nnqlvydWVPV------------------------------FDMQILNDlenKeN------------MLQLN 1049 Plasmodium falcip...
EGG20975  745 gwptk-----qaplqWSPL------------------------------MDFKQMATklsStT------------CWVVG 777  Cavenderia fascic...
CBZ08475  826 dwg----------gsWVPV------------------------------YDPRTLVDqsyA--------------LWVYG 851  Leishmania infant...
Q4E5R7    799 nwg----------gsWIPV------------------------------LDPRCMADqtyN--------------LWIWG 824  Trypanosoma cruzi
Q4GYD0    847 nwg----------gsWVPV------------------------------YDPRCMNDqtyN--------------LWIWG 872  Trypanosoma brucei
EGB08065  507 dfg----------wrFAPA------------------------------LDAAA-KRv--N-Ag---------DREWPVF 533  Aureococcus anoph...
EEC44446  853 assldaegptekhweWMPM------------------------------LDTVG-LRk--S-Rd---------DSFWPVT 889  Phaeodactylum tri...

5OGS_A    356 IHEn---------------------------pQQLRCIPCK-GSR---FPPT-LPRPAVAIL------SFKLP 390  human
EAX94780  820 ISD-----------------------------NKLFGCFLK-ENK---VPHA-YPLQGLSEV------Klmpl 852  Trichomonas vaginalis G3
EWS72657  734 MVD-----------------------------YKLAGFLLP-KDE---------LEPRLTQIyhekcfDMQLP 767  Tetrahymena thermophila ...
Q8IER6   1050 ENNqhilnetinknditsndihsqkddnedyiN---------SNMknaTPSK------------------LNP 1095 Plasmodium falciparum 3D7
EGG20975  778 LND-----------------------------SHIHCIVCTd------FPQT-LPRPILTPI------QINLP 808  Cavenderia fasciculata
CBZ08475  852 VSE-----------------------------S--ALLAYRySRDdpsYPAA-AASGLSTEL---------VP 883  Leishmania infantum JPCM5
Q4E5R7    825 VSD-----------------------------E--AVFAYRsCKSdppYPAA-VASGLPTehvrlflpltrcg 865  Trypanosoma cruzi
Q4GYD0    873 VCD-----------------------------E--SMLVYRsCKDdppYPAA-VASGLPTervslflpllhsg 913  Trypanosoma brucei
EGB08065  534 AVH-----------------------------GFVHCALLK-GGAp--YPPCrGAKPVLERL------ALRqp 568  Aureococcus anophagefferens
EEC44446  890 VYD-----------------------------GKLVCVPLK-GGMk--HPDA-VRRPVTAAL------GFRLP 923  Phaeodactylum tricornutu...
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