Conserved Protein Domain Family
SBF2
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pfam12335: SBF2 (this model, PSSM-Id:372054 is obsolete and has been replaced by 463536)
Myotubularin protein
This domain family is found in eukaryotes, and is approximately 220 amino acids in length. The family is found in association with pfam02141, pfam03456, pfam03455. This family is the middle region of SBF2, a member of the myotubularin family. Myotubularin-related proteins have been suggested to work in phosphoinositide-mediated signalling events that may also convey control of myelination. Mutations of SBF2 are implicated in Charcot-Marie-Tooth disease.
Links
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Statistics
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PSSM-Id: 372054
Aligned: 28 rows
Threshold Bit Score: 295.352
Created: 1-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EEC05449      533 VASQD-SVVSNSARRLEVLCNCINHVFDNKISDARKAMPAVLRALKSKAARLALTHELQHHVTGNKAVLEHQQFDLVVRL 611  black-legged ...
EEN59651       86 NRRDKfSGLNSSARRLEVMRNCINYIFDNKIQEAKKSFPAVLRGLKSKVTRLALCDELSLHMQQNRVVLENHQFDMVVRL 165  Florida lancelet
EDV28505      573 AL---------MLKRLEVLRKCVSNIFNNRIIEAKKMFSAVLSLLTSVQYRIALVEEFESYCLHSRVVLTFDQFDMVVRL 643  Trichoplax ad...
XP_005989750  535 IMDSTgPVF-NSERRLEVVRNCISFIFENKILETEKTLQAALRALKGKAARVCLTQELNKHVQQNLTLLDHQQFDYIVRM 613  coelacanth
XP_011670495   78 NFEGHrNLVNNSARRLEVLRTCINFIFENKILDARRLFPAVMRSLKSRVARQALLHELELHVNKNRAMLEPQQFSMVVRL 157  purple sea ur...
XP_014348815  512 AIDg--NALANSARRLEVVRNCITYIFENKMLEAKKLLPAVLRALKGRAAKRCLTIELNSHVQQNRAVLDDQQFDFIVRM 589  coelacanth
XP_011618152  566 TVDRNgNMIANSARRLEVVRNCITYIFENKMLEAKKLMPAVLRALKGRAARVCLTQELNQHVLQNRAVLDDQQFDYIVRM 645  torafugu
XP_023808450  547 TVDRNgCVMANSARRLEVVRNCISYIFENKMLEAKKLMPAVLRALKGRGARLCFTQELNQHVLQNRAVLDDQQFDYIVRM 626  Japanese medaka
POI21964       55 IMERNgNALANSARRLEVVRNCISYVFENKMLEAKKLFPAVLRAMKGRAARHCLTQELNLHVQQNRAVLDHQQFDFIVRM 134  Chinese bambo...
PNI79335      142 IMDKVtTVF-NSAQRLEVVRNCISFIFENKILETEKTLPAALRALKGKAARQCLTDELGLHVQQNRAILDHQQFDYIIRM 220  chimpanzee

EEC05449      612 MNCALQDDSALDEHGVAAGILPLSHAFCRKLCTGVMQFAYTCIQDHVVWGQLQFWEAAFYQDVQRDIRSLYLPHTASPQH 691  black-legged ...
EEN59651      166 INCALQDCSSMDEHGVAAGLLPLVCAFCRKLAPGVMQFAYTLVQDHPVWANLQFWEASFYTDVQKHIKELYHQPDRNGKV 245  Florida lancelet
EDV28505      644 INQALQEDDANDRNGVAAMILPFSASFCRKLSDNVHQFAYTCVWDHPVWDNPRFWERTFYLTCQKHVMNLYENSLIKKAN 723  Trichoplax ad...
XP_005989750  614 MNCALQHCSSSEEYTVAAALLPLTTAFCRKLSPGINQFAYTCVQDHPVWTSQQFWEAAFYSDVQCQIRALYLAAKEDTPG 693  coelacanth
XP_011670495  158 INAALQEDSHSEEFSLSMDFLPLISAFCRKLCPGIIQFAYTVTQDHPVFASHAFWETAFYADVEKNIQSLYVTPDNTPTY 237  purple sea ur...
XP_014348815  590 MNCALQDCSSVDEHGVAAALLPLVTAFCRKLGPGITQFSYSCVQEHVVWTNTQFWEAMFYSDVQDHIRKLYTESGEGDPS 669  coelacanth
XP_011618152  646 MNCTLQDCSHIDEHGIAAALLPLVTAFCRKLGAGITQFAYSCVQEHMVWTTMQFWESMFYSDVQNHIRALYLETEEVEQQ 725  torafugu
XP_023808450  627 MNCTLQDCSHMDEHGVAAALLPLVTAFCRKLGAGITQFAYSCVQEHTVWTNMQFWEAMFYSDVQNHIRALYLETEDGEQH 706  Japanese medaka
POI21964      135 MNCCLQDCTAMDEHGIAAALLPLVTAFCRKLSPGITQFAYSCVQEHVVWTNIQFWEAMFYSDVQNHIRALYLDSSEENHA 214  Chinese bambo...
PNI79335      221 MNCTLQDCSSLEEYNIAAALLPLTSAFYRKLAPGVSQFAYTCVQDHPIWTNQQFWETTFYNAVQEQVRSLYLSAKEDNHA 300  chimpanzee

EEC05449      692 GGHQ--------------------PNhqqpnnapgkqktpplspreskdstsswsridapkanfdlcnRRPAILSKAPEP 751  black-legged ...
EEN59651      246 PSSP--------------------GM------------------------------------------RRRVEVNRSLEK 263  Florida lancelet
EDV28505      724 KNA-----------------------------------------------------------------IEAKNDNKVEDV 738  Trichoplax ad...
XP_005989750  694 INLK--------------------QK------------------------------------------GTTGL----EQK 707  coelacanth
XP_011670495  238 EKKDvsqsfndafaagpdasgssaSS------------------------------------------AAANGLITSAER 275  purple sea ur...
XP_014348815  670 KQEC--------------------G--------------------------------------------------EQDVR 679  coelacanth
XP_011618152  726 NNTE--------------------LLng---------------------------------------------saSRREI 740  torafugu
XP_023808450  707 SISQ--------------------QQqdg--------------------------------------------sgSRKDI 722  Japanese medaka
POI21964      215 DEES--------------------TEe------------------------------------------------PQEAR 226  Chinese bambo...
PNI79335      301 PHLK--------------------QK-------------------------------------------DKLPDDHYQEK 317  chimpanzee

EEC05449      752 SALEIAAEQMRIQQngSLSKEELEELASREESTVYSQAIHFANRM 796  black-legged tick
EEN59651      264 SALDIAAEQLRLWP--HRSKDDQQELVNNEESTVYSQAIHYANRM 306  Florida lancelet
EDV28505      739 TAVETV----------ETAINTDTENGKPKAETTFGTT------L 767  Trichoplax adhaerens
XP_005989750  708 TAMDLAAEQLRLWP--SLSKEKQQELIQSEESTVFSQAIHYASLM 750  coelacanth
XP_011670495  276 SPLDIAAEQLRLQP--NMNHDAREEAKSNEESIVYSQAVHYANRM 318  purple sea urchin
XP_014348815  680 SALEIASEQRRFWP--TLPKEKQQELIQKEESTVFSQAIHYANRM 722  coelacanth
XP_011618152  741 SALELAseqnrlwptlskemqaervqkeestvfsqaihyanrmgy 785  torafugu
XP_023808450  723 SALELASEQSRLWP--TFGKEMQAELVQKEESTVFSQAIHYANRM 765  Japanese medaka
POI21964      227 SALEIASEQLRLWP--TMSREKQQELIQKEESTVFSQAIHYANRM 269  Chinese bamboo-partridge
PNI79335      318 TAMDLAAEQLRLWP--TLSKSTQQELVQHEESTVFSQAIHFANLM 360  chimpanzee
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